905586-69-8 | Az 960

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥98%	in stock	$151.00	$106.00
5mg	≥98%	in stock	$520.00	$364.00
10mg	≥98%	in stock	$818.00	$573.00
25mg	98% by HPLC	in stock	$1,826.00	$1,278.00
50mg	98%	in stock	$2,682.00	$1,878.00
100mg	98%	in stock	$4,788.00	$3,352.00
500mg	98% by HPLC	in stock	$16,913.00	$11,839.00
1000mg	98% by HPLC	in stock	$27,031.00	$18,922.00

Description

• Catalog Number: AH82400
• Chemical Name: Az 960
• CAS Number: 905586-69-8
• Molecular Formula: C18H16F2N6
• Molecular Weight: 354.3566
• MDL Number: MFCD16621127
• SMILES: N#Cc1cc(F)c(nc1N[C@H](c1ccc(cc1)F)C)Nc1n[nH]c(c1)C

Computed Properties

• Complexity: 503
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5
• XLogP3: 4.4

Literature

• Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia.

  International journal of cancer 20111115

• In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20110515

• AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells.

  Molecular cancer therapeutics 20101201

• Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

  The Journal of biological chemistry 20081121