-
Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury.
Toxicology in vitro : an international journal published in association with BIBRA 20180401
-
Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Chemical research in toxicology 20170515
-
Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.
Toxicology letters 20150702
-
A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Toxicological sciences : an official journal of the Society of Toxicology 20140101
-
[New drugs for small animals in 2011].
Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere 20121017
-
Topical bromfenac as an adjunctive treatment with intravitreal ranibizumab for exudative age-related macular degeneration.
Retina (Philadelphia, Pa.) 20121001
-
In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.
Chemical research in toxicology 20120820
-
Acute corneal melt associated with topical bromfenac use.
Eye & contact lens 20120701
-
Prospective randomized controlled trial of combination ranibizumab (Lucentis) and bromfenac (Xibrom) for neovascular age-related macular degeneration: a pilot study.
Retina (Philadelphia, Pa.) 20120301
-
Predicting psychopharmacological drug effects on actual driving performance (SDLP) from psychometric tests measuring driving-related skills.
Psychopharmacology 20120301
-
Ocular medicines in children: the regulatory situation related to clinical research.
BMC pediatrics 20120101
-
Update on twice-daily bromfenac sodium sesquihydrate to treat postoperative ocular inflammation following cataract extraction.
Clinical ophthalmology (Auckland, N.Z.) 20120101
-
A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data.
PloS one 20120101
-
Safety of besifloxacin ophthalmic suspension 0.6% as a prophylactic antibiotic following routine cataract surgery: results of a prospective, parallel-group, investigator-masked study.
Clinical ophthalmology (Auckland, N.Z.) 20120101
-
Comparison of bromfenac 0.09% QD to nepafenac 0.1% TID after cataract surgery: pilot evaluation of visual acuity, macular volume, and retinal thickness at a single site.
Clinical ophthalmology (Auckland, N.Z.) 20120101
-
Phase II placebo-controlled study of nepafenac ophthalmic suspension 0.1% for postoperative inflammation and ocular pain associated with cataract surgery in Japanese patients.
Journal of ophthalmic inflammation and infection 20111201
-
A randomized comparison of to-aqueous penetration of ketorolac 0.45%, bromfenac 0.09% and nepafenac 0.1% in cataract patients undergoing phacoemulsification.
Current medical research and opinion 20111201
-
Prostaglandin E2 inhibition of ketorolac 0.45%, bromfenac 0.09%, and nepafenac 0.1% in patients undergoing phacoemulsification.
Advances in therapy 20111201
-
Inflammation after phakic implants.
Ophthalmology 20111201
-
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
PLoS computational biology 20111201
-
Safety and efficacy of bromfenac ophthalmic solution (Bromday) dosed once daily for postoperative ocular inflammation and pain.
Ophthalmology 20111101
-
The kinetics of herpes virus on the ocular surface and suppression of its reactivation.
Cornea 20111001
-
NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway.
Laboratory investigation; a journal of technical methods and pathology 20110901
-
Once daily dosing of bromfenac ophthalmic solution 0.09% for postoperative ocular inflammation and pain.
Current medical research and opinion 20110901
-
Cataract and diabetic retinopathy.
Community eye health 20110901
-
Ocular penetration and anti-inflammatory activity of ketorolac 0.45% and bromfenac 0.09% against lipopolysaccharide-induced inflammation.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110401
-
Pharmacokinetic comparisons of bromfenac in DuraSite and Xibrom.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110201
-
Efficacy and tolerability of a combined gatifloxacin plus prednisolone formulation for topical prophylaxis after LASIK.
Clinical ophthalmology (Auckland, N.Z.) 20110101
-
Four cases of corneal perforation in patients with chronic graft-versus-host disease.
Molecular vision 20110101
-
Ex vivo corneal epithelial wound healing following exposure to ophthalmic nonsteroidal anti-inflammatory drugs.
Clinical ophthalmology (Auckland, N.Z.) 20110101
-
Treating ocular surface disease: new agents in development.
Clinical ophthalmology (Auckland, N.Z.) 20110101
-
Critical appraisal of ophthalmic ketorolac in treatment of pain and inflammation following cataract surgery.
Clinical ophthalmology (Auckland, N.Z.) 20110101
-
Evaluation of analgesic efficacy of bromfenac sodium ophthalmic solution 0.09% versus ketorolac tromethamine ophthalmic solution 0.5% following LASEK or Epi-LASIK.
Clinical ophthalmology (Auckland, N.Z.) 20110101
-
Erratum: corrigendum.
Clinical ophthalmology (Auckland, N.Z.) 20110101
-
Different cellular effects of four anti-inflammatory eye drops on human corneal epithelial cells: independent in active components.
Molecular vision 20110101
-
Combination therapies in ophthalmology: implications for intravitreal delivery.
Journal of ophthalmic & vision research 20110101
-
Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?
World journal of gastroenterology 20101207
-
Efficacy of bromfenac sodium ophthalmic solution in preventing cystoid macular oedema after cataract surgery in patients with diabetes.
Acta ophthalmologica 20101201
-
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug metabolism and disposition: the biological fate of chemicals 20101201
-
Efficacy and safety of bromfenac for the treatment of corneal ulcer pain.
Advances in therapy 20101001
-
Cytotoxicity of topical medications used for infection and inflammation control after cataract surgery in cultured corneal endothelial cells.
Biocontrol science 20100901
-
NSAIDs in combination therapy for the treatment of chronic pseudophakic cystoid macular edema.
Retina (Philadelphia, Pa.) 20100201
-
Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data.
BMC bioinformatics 20100101
-
Difluprednate ophthalmic emulsion 0.05% (Durezol) administered two times daily for managing ocular inflammation and pain following cataract surgery.
Clinical ophthalmology (Auckland, N.Z.) 20100101
-
Cytotoxicity of five fluoroquinolone and two nonsteroidal anti-inflammatory benzalkonium chloride-free ophthalmic solutions in four corneoconjunctival cell lines.
Clinical ophthalmology (Auckland, N.Z.) 20100101
-
Data-driven identification of co-morbidities associated with rheumatoid arthritis in a large US health plan claims database.
BMC musculoskeletal disorders 20100101
-
Use of nepafenac (Nevanac) in combination with intravitreal anti-VEGF agents in the treatment of recalcitrant exudative macular degeneration requiring monthly injections.
Clinical ophthalmology (Auckland, N.Z.) 20100101
-
Ocular pharmacokinetics of 0.45% ketorolac tromethamine.
Clinical ophthalmology (Auckland, N.Z.) 20100101
-
Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins.
Drug metabolism and disposition: the biological fate of chemicals 20091201
-
Ophthalmic utility of topical bromfenac, a twice-daily nonsteroidal anti-inflammatory agent.
Expert opinion on pharmacotherapy 20091001
-
Differential effects of non-steroidal anti-inflammatory drugs on mitochondrial dysfunction during oxidative stress.
Archives of biochemistry and biophysics 20091001
-
Vitreous nonsteroidal antiinflammatory drug concentrations and prostaglandin E2 levels in vitrectomy patients treated with ketorolac 0.4%, bromfenac 0.09%, and nepafenac 0.1%.
Retina (Philadelphia, Pa.) 20091001
-
Efficacy of ophthalmic nonsteroidal antiinflammatory drugs in suppressing anterior capsule contraction and secondary posterior capsule opacification.
Journal of cataract and refractive surgery 20090901
-
Concentration and dosing of ketorolac versus bromfenac.
Journal of cataract and refractive surgery 20090701
-
Comparison of efficacy of bromfenac sodium 0.1% ophthalmic solution and fluorometholone 0.02% ophthalmic suspension for the treatment of allergic conjunctivitis.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601
-
Aqueous prostaglandin E(2) of cataract patients at trough ketorolac and bromfenac levels after 2 days dosing.
Advances in therapy 20090601
-
Effect of bromfenac ophthalmic solution on ocular inflammation following cataract surgery.
Acta ophthalmologica 20090501
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20090401
-
Cyclooxygenase (COX)-inhibiting drug reduces HSV-1 reactivation in the mouse eye model.
Current eye research 20090301
-
Psychoactive medication and traffic safety.
International journal of environmental research and public health 20090301
-
Topical bromfenac 0.09% vs. ketorolac 0.4% for the control of pain, photophobia, and discomfort following PRK.
Journal of refractive surgery (Thorofare, N.J. : 1995) 20090201
-
Randomized controlled trial design in rheumatoid arthritis: the past decade.
Arthritis research & therapy 20090101
-
Information about ADRs explored by pharmacovigilance approaches: a qualitative review of studies on antibiotics, SSRIs and NSAIDs.
BMC clinical pharmacology 20090101
-
Management of ocular inflammation and pain following cataract surgery: focus on bromfenac ophthalmic solution.
Clinical ophthalmology (Auckland, N.Z.) 20090101
-
Retrospective review of the efficacy of topical bromfenac (0.09%) as an adjunctive therapy for patients with neovascular age-related macular degeneration.
Retina (Philadelphia, Pa.) 20090101
-
Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.
PloS one 20090101
-
Etiology and treatment of the inflammatory causes of cystoid macular edema.
Journal of inflammation research 20090101
-
Ocular pharmacokinetics of a single dose of bromfenac sodium ophthalmic solution 0.1% in human aqueous humor.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201
-
Off-label promotion, on-target sales.
PLoS medicine 20081001
-
Comparison of ketorolac 0.4% and bromfenac 0.09% at trough dosing: aqueous drug absorption and prostaglandin E2 levels.
Journal of cataract and refractive surgery 20080901
-
Re: Pharmacokinetics and pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac.
Journal of cataract and refractive surgery 20080801
-
24-hour evaluation of the ocular distribution of (14)C-labeled bromfenac following topical instillation into the eyes of New Zealand White rabbits.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801
-
Cytotoxicity of ophthalmic solutions with and without preservatives to human corneal endothelial cells, epithelial cells and conjunctival epithelial cells.
Clinical & experimental ophthalmology 20080801
-
Topical ocular delivery of NSAIDs.
The AAPS journal 20080601
-
Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspension.
Clinical ophthalmology (Auckland, N.Z.) 20080601
-
Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity.
Cell biology and toxicology 20080101
-
The systemic safety of bromfenac ophthalmic solution 0.09%.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071201
-
A review of the use of ketorolac tromethamine 0.4% in the treatment of post-surgical inflammation following cataract and refractive surgery.
Clinical ophthalmology (Auckland, N.Z.) 20071201
-
Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery.
Clinical ophthalmology (Auckland, N.Z.) 20071201
-
Bromfenac ophthalmic solution 0.09% (Xibrom) for postoperative ocular pain and inflammation.
Ophthalmology 20070901
-
In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac.
Journal of cataract and refractive surgery 20070901
-
Corneal melting and perforation in Stevens Johnson syndrome following topical bromfenac use.
Journal of cataract and refractive surgery 20070901
-
Effects of topical anti-inflammatory agents in a botulinum toxin B-induced mouse model of keratoconjunctivitis sicca.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070201
-
Effect of ophthalmic solution components on acrylic intraocular lenses.
Journal of cataract and refractive surgery 20070101
-
Topical bromfenac sodium for long-term management of vernal keratoconjunctivitis.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20070101
-
Effects of nonsteroidal ophthalmic drops on epithelial healing and pain in patients undergoing bilateral photorefractive keratectomy (PRK).
Advances in therapy 20070101
-
Misuse and abuse of topically applied nonsteroidal anti-inflammatory drugs.
Cornea 20061201
-
Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug.
Cornea 20061201
-
Hepatic disorders in patients treated with COX-2 selective inhibitors or nonselective NSAIDs: a case/noncase analysis of spontaneous reports.
Clinical therapeutics 20060801
-
Effects of an opioid (oxycodone/paracetamol) and an NSAID (bromfenac) on driving ability, memory functioning, psychomotor performance, pupil size, and mood.
The Clinical journal of pain 20060601
-
Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium.
Current medical research and opinion 20060601
-
A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience.
Pharmacoepidemiology and drug safety 20060401
-
Hy's law: predicting serious hepatotoxicity.
Pharmacoepidemiology and drug safety 20060401
-
How can 'Hy's law' help the clinician?
Pharmacoepidemiology and drug safety 20060401
-
Ximelagatran: direct thrombin inhibitor.
Vascular health and risk management 20060301
-
Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug.
Cornea 20060201
-
Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac.
Current medical research and opinion 20060201
-
Global experience with Xibrom (bromfenac ophthalmic solution) 0.09%: the first twice-daily ophthalmic nonsteroidal anti-inflammatory drug.
International ophthalmology clinics 20060101
-
New drugs and dosage forms.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050501
-
Do preclinical testing strategies help predict human hepatotoxic potentials?
Toxicologic pathology 20050101
-
Drug-induced liver disease in 2003.
Current opinion in gastroenterology 20040501
-
Drug-induced liver injury.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301
-
Analgesics for acute pain: Meeting the United States Food and Drug Administration's requirements for proof of efficacy.
The Clinical journal of pain 20040101
-
Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis.
Japanese journal of ophthalmology 20040101
-
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201
-
Drug-induced hepatotoxicity.
The New England journal of medicine 20030731
-
Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology 20030601
-
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost.
The British journal of ophthalmology 20030301
-
Effects of topical corticosteroids and nonsteroidal anti-inflammatory drugs on prostaglandin e2-induced aqueous flare elevation in pigmented rabbits.
Ophthalmic research 20030101
-
Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs.
Seminars in liver disease 20020101
-
Acute liver failure.
Current opinion in gastroenterology 20010501
-
Serious liver injury. Leading reason for drug removals, restrictions.
FDA consumer 20010101
-
Structure toxicity relationships--how useful are they in predicting toxicities of new drugs?
Advances in experimental medicine and biology 20010101
-
Bromfenac (Duract)-associated hepatic failure requiring liver transplantation.
The American journal of gastroenterology 19990801
