917879-39-1 | MK-2461

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$82.00	$57.00
2mg	98+%	in stock	$146.00	$103.00
5mg	98+%	in stock	$218.00	$153.00
100mg	98% by HPLC	in stock	$3,990.00	$2,793.00
500mg	98% by HPLC	in stock	$12,760.00	$8,932.00
1000mg	98% by HPLC	in stock	$20,386.00	$14,270.00

Description

• Catalog Number: AB52643
• Chemical Name: MK-2461
• CAS Number: 917879-39-1
• Molecular Formula: C24H25N5O5S
• Molecular Weight: 495.5508
• MDL Number: MFCD11977739
• SMILES: Cn1ncc(c1)c1cnc2c(c1)c(=O)c1cc(ccc1cc2)NS(=O)(=O)N(C[C@@H]1COCCO1)C

Computed Properties

• Complexity: 895
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 1.2

Literature

• Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

  Journal of medicinal chemistry 20110623

• Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

  European journal of medicinal chemistry 20110601

• MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

  Cancer research 20100215