919486-40-1 | As1517499

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$22.00	$16.00
5mg	95%	in stock	$56.00	$39.00
10mg	95%	in stock	$77.00	$54.00

Description

• Catalog Number: AX46894
• Chemical Name: As1517499
• CAS Number: 919486-40-1
• Molecular Formula: C20H20ClN5O2
• Molecular Weight: 397.8581
• MDL Number: MFCD24038757
• SMILES: NC(=O)c1cnc(nc1NCc1ccccc1)NCCc1ccc(c(c1)Cl)O

Computed Properties

• Complexity: 491
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 8
• XLogP3: 4

Literature

• Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.

  Molecules (Basel, Switzerland) 20140808

• Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells.

  Pharmacological research 20100201

• A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice.

  American journal of respiratory cell and molecular biology 20091101

• Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors.

  Bioorganic & medicinal chemistry 20080701

• Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors.

  Bioorganic & medicinal chemistry 20070115

• Suppressor T cells and host resistance to tye 111 pneumococcus after treatment with antilymphocyte serum.

  Infection and immunity 19751201