925701-46-8 | KU-60019

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$42.00	$29.00
5mg	98%	in stock	$165.00	$115.00
10mg	98%	in stock	$205.00	$143.00
25mg	98%	in stock	$358.00	$250.00
50mg	98%	in stock	$468.00	$327.00

Description

• Catalog Number: AH85581
• Chemical Name: KU-60019
• CAS Number: 925701-46-8
• Molecular Formula: C30H33N3O5S
• Molecular Weight: 547.6651
• MDL Number: MFCD18384974
• SMILES: O=C(Nc1ccc2c(c1)Cc1c(S2)c(ccc1)c1cc(=O)cc(o1)N1CCOCC1)CN1CC(C)OC(C1)C

Computed Properties

• Complexity: 972
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 3.5

Literature

• Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.

  Environmental health perspectives 20160101

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.

  The Journal of biological chemistry 20120406

• Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.

  Cell cycle (Georgetown, Tex.) 20120315

• Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.

  Molecular cancer therapeutics 20091001