926037-48-1 | Radotinib

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$8.00	$6.00
5mg	98+%	in stock	$18.00	$13.00
10mg	98+%	in stock	$27.00	$19.00
25mg	98+%	in stock	$42.00	$30.00
100mg	98+%	in stock	$99.00	$69.00
250mg	98+%	in stock	$157.00	$110.00
1g	98+%	in stock	$424.00	$297.00

Description

• Catalog Number: AH94945
• Chemical Name: Radotinib
• CAS Number: 926037-48-1
• Molecular Formula: C27H21F3N8O
• Molecular Weight: 530.5038
• MDL Number: MFCD27956910
• SMILES: Cc1ncn(c1)c1cc(NC(=O)c2ccc(c(c2)Nc2nccc(n2)c2nccnc2)C)cc(c1)C(F)(F)F

Computed Properties

• Complexity: 818
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 3.9

Literature

• Radotinib is an effective inhibitor of native and kinase domain-mutant BCR-ABL1.

  Leukemia 20150901

• Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors.

  Haematologica 20140701

• Pushing the limits of targeted therapy in chronic myeloid leukaemia.

  Nature reviews. Cancer 20120724