929095-18-1 | Gsk461364

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥95%	in stock	$44.00	$31.00
5mg	≥95%	in stock	$151.00	$106.00
10mg	≥95%	in stock	$278.00	$195.00
50mg	95%	in stock	$320.00	$224.00
100mg	95%	in stock	$449.00	$314.00
250mg	95%	in stock	$720.00	$504.00

Description

• Catalog Number: AC90205
• Chemical Name: Gsk461364
• CAS Number: 929095-18-1
• Molecular Formula: C27H28F3N5O2S
• Molecular Weight: 543.6037
• MDL Number: MFCD12755419
• SMILES: CN1CCN(CC1)Cc1ccc2c(c1)n(cn2)c1cc(c(s1)C(=O)N)O[C@@H](c1ccccc1C(F)(F)F)C

Computed Properties

• Complexity: 814
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 38
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 4.7

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).

  Oncotarget 20111201

• Comprehensive analysis of kinase inhibitor selectivity.

  Nature biotechnology 20111030

• Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

  Chemistry & biology 20101124

• Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.

  Cancer research 20090901