93-35-6 | 7-Hydroxycoumarin

Packsize	Purity	Availability	Price	Discounted Price
25mg	98%	in stock	$6.00	$4.00
5g	98%	in stock	$10.00	$7.00
25g	98%	in stock	$29.00	$20.00
100g	98%	in stock	$93.00	$65.00

Description

• Catalog Number: AB80295
• Chemical Name: 7-Hydroxycoumarin
• CAS Number: 93-35-6
• Molecular Formula: C9H6O3
• Molecular Weight: 162.1421
• MDL Number: MFCD00014738
• SMILES: Oc1ccc2c(c1)oc(=O)cc2
• NSC Number: 19790

Computed Properties

• Complexity: 222
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.6

Literature

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• Synthesis and free radical scavenging activity of some new spiropyranocoumarins.

  Bioorganic & medicinal chemistry letters 20081101

• 7-hydroxycoumarin-hemicyanine hybrids: a new class of far-red emitting fluorogenic dyes.

  Organic letters 20081002

• [Studies on chemical constituents from Elaeocarpus sylvestris].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081001

• Protective effects of dietary chamomile tea on diabetic complications.

  Journal of agricultural and food chemistry 20080910

• Synthesis and properties of umbelliferone-nitroxide radical hybrid compounds as fluorescence and spin-label probes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080901

• Studies of coumarins from the Chinese drug Qianhu, XXVII: structure of a new simple coumarin glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum.

  Chemical & pharmaceutical bulletin 20080901

• [Study on fluorescent properties of coumarin derivatives and determination of trace iron].

  Guang pu xue yu guang pu fen xi = Guang pu 20080901

• Latent fluorophores based on a self-immolative linker strategy and suitable for protease sensing.

  Bioconjugate chemistry 20080801

• Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency.

  Journal of enzyme inhibition and medicinal chemistry 20080801

• [Studies on chemical constituents of Peucedanum delavayi].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

• Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle.

  Journal of experimental botany 20080701

• Analysis of ciprofloxacin by a simple high-performance liquid chromatography method.

  Journal of chromatographic science 20080701

• A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening.

  Assay and drug development technologies 20080601

• [Studies on chemical constituents of Saussurea laniceps].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• [Study on steroids of Cacalia tangutica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

• [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080401

• Optimizing glycosyltransferase specificity via 'hot spot' saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

  Chemistry & biology 20080401

• [Studies on chemical constituents of the roots of Angelica pubescens].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080401

• Separation and identification of botanical insecticide 7-hydroxycoumarin and its biological activity against Aphis craccivora and Culex pipiens pallens.

  Natural product research 20080310

• Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae.

  Bioorganic & medicinal chemistry 20080301

• Artemisinin and CYP2A6 activity in healthy subjects.

  European journal of clinical pharmacology 20080301

• Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.

  Journal of medicinal chemistry 20080227

• Rapid probing of photocatalytic activity on titania-based self-cleaning materials using 7-hydroxycoumarin fluorescent probe.

  Analytica chimica acta 20080204

• Development of micromarkers with various photoluminescence colors as tracers for shadowing pursuits.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080201

• Substrate arrays for fluorescence-based enzyme fingerprinting and high-throughput screening.

  Annals of the New York Academy of Sciences 20080101

• Comparison of the effect of 4-hydroxycoumarin and umbelliferone on the phase transition of dipalmitoylphosphatidylcholine (DPPC) bilayers.

  Pharmacological reports : PR 20080101

• TAC-scaffolded tripeptides as artificial hydrolytic receptors: a combinatorial approach toward esterase mimics.

  Journal of combinatorial chemistry 20080101

• A review of coumarin derivatives in pharmacotherapy of breast cancer.

  Current medicinal chemistry 20080101

• Biosynthetic origin of the 1-oxygen of umbelliferone in the root tissue of sweet potato.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

• In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data.

  Drug metabolism and drug interactions 20080101

• A novel fluorogenic coumarin substrate for monitoring acid phosphatase activity at low pH environment.

  Current chemical genomics 20080101

• [Chemical constituents from roots of Ferula sinkiangensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071101

• Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives.

  Bioorganic & medicinal chemistry letters 20071015

• Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida.

  Journal of ethnopharmacology 20070815

• Rapid densitometric method for simultaneous analysis of umbelliferone, psoralen, and eugenol in herbal raw materials using HPTLC.

  Journal of separation science 20070801

• Effect of umbelliferone on tail tendon collagen and haemostatic function in streptozotocin-diabetic rats.

  Basic & clinical pharmacology & toxicology 20070801

• Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae).

  Journal of ethnopharmacology 20070725

• Protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin-induced diabetic rats.

  European journal of pharmacology 20070702

• Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition.

  European journal of medicinal chemistry 20070701

• Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture.

  Planta medica 20070701

• Capillary electrochromatography of selected phenolic compounds of Chamomilla recutita.

  Journal of chromatography. A 20070622

• The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy.

  Blood 20070601

• Induction of phase I and II drug metabolism in rat small intestine and colon in vitro.

  Drug metabolism and disposition: the biological fate of chemicals 20070601

• Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.

  Fundamental & clinical pharmacology 20070601

• Evaluation of the content and stability of the constituents of mother tinctures and tinctures: the case of Crataegus oxyacantha L. and Hieracium pilosella L.

  Journal of pharmaceutical and biomedical analysis 20070509

• A review of the hepatotoxic plant Lantana camara.

  Critical reviews in toxicology 20070501

• Determination of six bioactive components of Saussurea katochaete by capillary electrophoresis.

  Biomedical chromatography : BMC 20070401

• Fluorogenic substrates for lipases, esterases, and acylases using a TIM-mechanism for signal release.

  Biotechnology journal 20070201

• CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?

  Pharmacogenomics 20070201

• Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis.

  The Journal of biological chemistry 20070105

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment.

  Microbes and infection 20070101

• [Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070101

• Antitumor and immunomodulatory effect of coumarin and 7-hydroxycoumarin against Sarcoma 180 in mice.

  Journal of experimental therapeutics & oncology 20070101

• [Studies on the chemical constituents of the aerial parts of Seseli mairei].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070101

• Influence of umbelliferone on membrane-bound ATPases in streptozotocin-induced diabetic rats.

  Pharmacological reports : PR 20070101

• Phytochemical and antinociceptive properties of Matayba elaeagnoides Radlk. barks.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

• New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents.

  Metal-based drugs 20070101

• Influence of umbelliferone on glycoprotein components in diabetic rats.

  Toxicology mechanisms and methods 20070101

• Tetrapleura tetraptera: molluscicidal activity and chemical constituents.

  African journal of traditional, complementary, and alternative medicines : AJTCAM 20070101

• Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata.

  Phytochemistry 20061201

• In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.

  Drug metabolism and pharmacokinetics 20061201

• Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus.

  Archives of pharmacal research 20061201

• [Studies on chemical constituents from fruits of Paliurus ramosissimus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

  PLoS medicine 20061101

• Simultaneous determination of urinary metabolites of methoxypsoralens in human and Umbelliferae medicines by high-performance liquid chromatography.

  Journal of chromatographic science 20060901

• [Tissue-like cultures of rat hepatocytes in study of phase I and phase II drug metabolism].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060901

• Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity.

  Archives of pharmacal research 20060801

• Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers.

  Drug metabolism and disposition: the biological fate of chemicals 20060701

• Interface of AOT/Brij mixed reverse micellar systems: conductometric and spectrophotometric investigations.

  Journal of colloid and interface science 20060615

• Antioxidant role of Umbelliferone in STZ-diabetic rats.

  Life sciences 20060613

• Molluscicidal activity of Ferula asafoetida, Syzygium aromaticum and Carum carvi and their active components against the snail Lymnaea acuminata.

  Chemosphere 20060601

• Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.

  Drug metabolism and disposition: the biological fate of chemicals 20060401

• Relationships between chemical composition, physical properties and transfection efficiency of polysaccharide-spermine conjugates.

  Biomaterials 20060301

• Accumulation of coumarins in Arabidopsis thaliana.

  Phytochemistry 20060201

• Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach.

  Environmental health perspectives 20060101

• [A new dicoumarin from stem bark of Wikstroemia indica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060101

• Inter-species comparison of 7-hydroxycoumarin glucuronidation and sulfation in liver S9 fractions.

  In vitro cellular & developmental biology. Animal 20060101

• Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation.

  Methods in molecular biology (Clifton, N.J.) 20060101

• Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families.

  Methods in molecular biology (Clifton, N.J.) 20060101

• Electrochemical profiles of Herba Saussureae Involucratae by capillary electrophoresis with electrochemical detection.

  Phytochemical analysis : PCA 20060101

• Gitksan medicinal plants--cultural choice and efficacy.

  Journal of ethnobiology and ethnomedicine 20060101

• Rapid analysis of coumarins using surface plasmon resonance.

  Journal of AOAC International 20060101

• Chemical constituents of Selinum cryptotaenium.

  Journal of Asian natural products research 20060101

• Ethnopharmacological evaluation of radal (leaves of Lomatia hirsuta) and isolation of 2-methoxyjuglone.

  BMC complementary and alternative medicine 20060101

• Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats.

  Journal of medicinal food 20060101

• Synthesis, characterization, and cytotoxic activity of new lanthanum(III) complexes of bis-coumarins.

  Bioinorganic chemistry and applications 20060101

• Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors.

  Bioinorganic chemistry and applications 20060101

• A direct fluorometric assay for tissue transglutaminase.

  Analytical biochemistry 20051215

• Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.

  Biochemical and biophysical research communications 20051209

• Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.

  Drug metabolism and disposition: the biological fate of chemicals 20051101

• Synthesis and antiinflammatory activity of coumarin derivatives.

  Journal of medicinal chemistry 20051006

• New diorganotin(IV) derivatives of 7-hydroxycoumarin (umbelliferone) and their adducts with 1,10-phenanthroline.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001

• Activation of mitogen activated protein kinase pathways and melanogenesis by novel nitro-derivatives of 7-hydroxycomarin in human malignant melanoma cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901

• An odorant-binding protein facilitates odorant transfer from air to hydrophilic surroundings in the blowfly.

  Chemical senses 20050901

• Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin.

  Cancer chemotherapy and pharmacology 20050801

• Effects of coumarin and 7OH-coumarin on bcl-2 and Bax expression in two human lung cancer cell lines in vitro.

  Cell biology international 20050801

• Accumulation of biologically active furanocoumarins in agitated cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams.

  Die Pharmazie 20050801

• [Interaction between bovine serum albumin and umbelliferone with/without metal ions of Cu2+ or Zn2+].

  Guang pu xue yu guang pu fen xi = Guang pu 20050801

• Antihyperlipidemic and antidiabetic effects of umbelliferone in streptozotocin diabetic rats.

  The Yale journal of biology and medicine 20050701

• Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases.

  Analytical biochemistry 20050601

• Sulfation in dog.

  Current drug metabolism 20050601

• Post-stress metabolism involves umbelliferone production in anthocyanin-producing and nonproducing cells of Glehnia littoralis suspension cultures.

  Journal of plant physiology 20050601

• Plant-derived anti-inflammatory compounds affect MIF tautomerase activity.

  International immunopharmacology 20050501

• In vitro free radical and ONOO- scavengers from Sophora flavescens.

  Archives of pharmacal research 20050501

• Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water.

  Free radical research 20050501

• Impact of umbelliferone on erythrocyte redox status in STZ-diabetic rats.

  The Yale journal of biology and medicine 20050501

• Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6.

  The Journal of biological chemistry 20050401

• Design and development of a fluorescent probe for monitoring hydrogen peroxide using photoinduced electron transfer.

  Bioorganic & medicinal chemistry 20050215

• Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice.

  Cancer chemotherapy and pharmacology 20050201

• The influence of brain death on liver function.

  Liver international : official journal of the International Association for the Study of the Liver 20050201

• Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8.

  Drug metabolism and disposition: the biological fate of chemicals 20050101

• A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies.

  Journal of pharmacological and toxicological methods 20050101

• [Determination of scopoletin and umbelliferone contents in Saussurea medusa Maxim by high-performance liquid chromatography].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050101

• Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20050101

• Accumulation of biologically active furanocoumarins in Ruta graveolens ssp. divaricata (Tenore) Gams in vitro culture.

  Die Pharmazie 20050101

• Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse.

  In vitro cellular & developmental biology. Animal 20050101

• Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese population.

  Drug metabolism and pharmacokinetics 20041201

• Determination of CC-5013, an analogue of thalidomide, in human plasma by liquid chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041125

• Evidence for concurrent effects of exposure to environmental cadmium and lead on hepatic CYP2A6 phenotype and renal function biomarkers in nonsmokers.

  Environmental health perspectives 20041101

• A study of the role of cell cycle events mediating the action of coumarin derivatives in human malignant melanoma cells.

  Cancer letters 20041008

• Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats.

  British journal of cancer 20041004

• Novel squalene-hopene cyclase inhibitors derived from hydroxycoumarins and hydroxyacetophenones.

  Chemical & pharmaceutical bulletin 20041001

• Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives.

  Bioscience, biotechnology, and biochemistry 20041001

• Umbelliferone released from hairy root cultures of Pharbitis nil treated with copper sulfate and its subsequent glucosylation.

  Bioscience, biotechnology, and biochemistry 20040901

• Metabolic and structural viability of precision-cut rat lung slices in culture.

  Xenobiotica; the fate of foreign compounds in biological systems 20040801

• Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.

  Archives of biochemistry and biophysics 20040715

• Effect of bisphenol A on drug metabolising enzymes in rat hepatic microsomes and precision-cut rat liver slices.

  Archives of toxicology 20040701

• Validated assays for human cytochrome P450 activities.

  Drug metabolism and disposition: the biological fate of chemicals 20040601

• Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation.

  Organic & biomolecular chemistry 20040521

• Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase.

  Bioorganic & medicinal chemistry letters 20040503

• Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes.

  Biochimica et biophysica acta 20040503

• An active and water-soluble truncation mutant of the human UDP-glucuronosyltransferase 1A9.

  Molecular pharmacology 20040401

• Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects.

  Toxicology letters 20040321

• Investigation of intracellular signalling events mediating the mechanism of action of 7-hydroxycoumarin and 6-nitro-7-hdroxycoumarin in human renal cells.

  Cancer letters 20040308

• Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru.

  Journal of natural products 20040301

• Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines.

  Lung cancer (Amsterdam, Netherlands) 20040301

• [Isolation and structure identification of the chemical constituents from pine needles of Pinus massoniana Lamb].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040301

• Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon.

  Xenobiotica; the fate of foreign compounds in biological systems 20040301

• Phase I and II enzyme characterization of two sources of HepG2 cell lines.

  Xenobiotica; the fate of foreign compounds in biological systems 20040301

• Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation.

  Toxicology in vitro : an international journal published in association with BIBRA 20040201

• Absolute stereochemistry of dihydrofuroangelicins bearing C-8 substituted double bonds: a combined chemical/exciton chirality protocol.

  Organic & biomolecular chemistry 20040107

• [Isolation and structural identification of chemical constituents from Selaginella tamariscina (Beauv.) Spring].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040101

• Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer.

  Current pharmaceutical design 20040101

• Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.

  Xenobiotica; the fate of foreign compounds in biological systems 20040101

• Quantitative changes of secondary metabolites of Matricaria chamomilla by abiotic stress.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

• Genetics of tobacco use.

  Tobacco induced diseases 20040101

• Study of inhibition of CYP2A6 by some drugs derived from quinoline.

  The Journal of pharmacy and pharmacology 20031201

• 'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.

  Xenobiotica; the fate of foreign compounds in biological systems 20031201

• Modulation of mitogen-activated protein kinases by 6-nitro-7-hydroxycoumarin mediates apoptosis in renal carcinoma cells.

  European journal of pharmacology 20031128

• The first fluorogenic assay for detecting a Baeyer-Villigerase activity in microbial cells.

  Organic & biomolecular chemistry 20031021

• Coumarins from Peucedanum wulongense.

  Journal of Asian natural products research 20030901

• Application of capillary electrophoresis with pH-mediated sample stacking to analysis of coumarin metabolites in microsomal incubations.

  Journal of pharmaceutical and biomedical analysis 20030808

• A low background high-throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone.

  Bioorganic & medicinal chemistry letters 20030707

• Interactions of a series of novel spiropyranocoumarin derivatives with reactive oxygen species.

  The Journal of pharmacy and pharmacology 20030701

• Spectrofluorimetric analysis of 7-hydroxycoumarin binding to bovine phenol sulfotransferase.

  Biochimica et biophysica acta 20030530

• Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.

  Journal of natural products 20030501

• Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin.

  International journal of clinical pharmacology and therapeutics 20030401

• Fluorogenic stereochemical probes for transaldolases.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20030217

• Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid.

  Journal of agricultural and food chemistry 20030212

• Comparative metabolism and kinetics of coumarin in mice and rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030201

• Protection of coumarins against linoleic acid hydroperoxide-induced cytotoxicity.

  Chemico-biological interactions 20030106

• Is neuroprotective efficacy of nNOS inhibitor 7-NI dependent on ischemic intracellular pH?

  American journal of physiology. Heart and circulatory physiology 20030101

• CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6.

  Xenobiotica; the fate of foreign compounds in biological systems 20030101

• Chemical constituents from the Hydrangea chinensis.

  Archives of pharmacal research 20030101

• Potential functional foods in the traditional Maori diet.

  Mutation research 20030101

• Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel.

  In vitro cellular & developmental biology. Animal 20030101

• Structural requirements of hydroxylated coumarins for in vitro anti-Helicobacter pylori activity.

  In vivo (Athens, Greece) 20030101

• Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

• Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.

  Journal of natural products 20021101

• Characterization of testosterone metabolism and 7-hydroxycoumarin conjugation by rat and human liver slices after storage in liquid nitrogen for 1 h up to 6 months.

  Xenobiotica; the fate of foreign compounds in biological systems 20021101

• [Prediction of eluotropic sequence of solutes in countercurrent chromatography].

  Se pu = Chinese journal of chromatography 20021101

• Inhibition of bovine phenol sulfotransferase (bSULT1A1) by CoA thioesters. Evidence for positive cooperativity and inhibition by interaction with both the nucleotide and phenol binding sites.

  The Journal of biological chemistry 20021018

• A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma.

  Biomedical chromatography : BMC 20020901

• Phenotypic polymorphism of CYP2A6 activity in a Chinese population.

  European journal of clinical pharmacology 20020801

• [Studies on the chemical constituents from the roots and rhizomes of Gerbera piloselloides].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801

• Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices.

  Xenobiotica; the fate of foreign compounds in biological systems 20020501

• Superoxide organic chemistry within the liposomal bilayer, part II: a correlation between location and chemistry.

  Free radical biology & medicine 20020401

• Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females.

  Pharmacogenetics 20020401

• Some coumarins and triphenylethene derivatives as inhibitors of human testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD type 3): further studies with tamoxifen on the rat testes microsomal enzyme.

  Journal of enzyme inhibition and medicinal chemistry 20020401

• A novel ISFET-type biosensor based on P450 monooxygenases.

  Biosensors & bioelectronics 20020301

• Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarin in human liver microsomes treated with alamethicin.

  Drug metabolism and disposition: the biological fate of chemicals 20020301

• A rapid fluorescence-based assay for detecting soluble methane monooxygenase.

  Applied microbiology and biotechnology 20020201

• Inhibitory effects of phenylpropanoid metabolites on copper-induced protein oxidative modification of mice brain homogenate, in vitro.

  Biological trace element research 20020201

• An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles.

  Biochemical and biophysical research communications 20020111

• Induction of 4-hydroxycinnamate decarboxylase in Klebsiella oxytoca cells exposed to substrates and non-substrate 4-hydroxycinnamate analogs.

  Bioscience, biotechnology, and biochemistry 20011201

• [Constituents of Liguliria vellerea (Franch.) Hand-Mazz].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011201

• Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin.

  Journal of molecular biology 20011130

• Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products.

  Archives of biochemistry and biophysics 20011101

• Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin.

  Lung cancer (Amsterdam, Netherlands) 20011101

• [Nonpolar components of the leaves of Philadelphus coronarius L].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20011101

• Characterization of peroxidase-mediated chlorophyll bleaching in strawberry fruit.

  Phytochemistry 20011001

• Tissue slices revisited: evaluation and development of a short-term incubation for integrated drug metabolism.

  Drug metabolism and disposition: the biological fate of chemicals 20011001

• The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.

  Archives of biochemistry and biophysics 20011001

• Study of the in vitro cytotoxic potential of natural and synthetic coumarin derivatives using human normal and neoplastic skin cell lines.

  Melanoma research 20011001

• A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.

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