93117-08-9 | 5-Aminoisoquinolin-1-ol

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$33.00	$23.00
250mg	98%	in stock	$71.00	$50.00
1g	98%	in stock	$203.00	$142.00
5g	98%	in stock	$573.00	$402.00
10g	98%	in stock	$946.00	$662.00
25g	98%	in stock	$1,879.00	$1,316.00

Description

• Catalog Number: AC87147
• Chemical Name: 5-Aminoisoquinolin-1-ol
• CAS Number: 93117-08-9
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.1726
• MDL Number: MFCD06198896
• SMILES: Nc1cccc2c1cc[nH]c2=O

Computed Properties

• Complexity: 225
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• XLogP3: 0.7

Literature

• 5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt/GSK-3β signaling pathway in H9c2 cardiomyocytes.

  Toxicology and applied pharmacology 20130401

• Dopaminochrome induces caspase-independent apoptosis in the mesencephalic cell line, MN9D.

  Journal of neurochemistry 20120701

• 5-Aminoisoquinolinone reduces the expression of vascular endothelial growth factor-C via the nuclear factor-κB signaling pathway in CT26 cells.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.

  Journal of enzyme inhibition and medicinal chemistry 20111201

• 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

  Journal of medicinal chemistry 20110414

• Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor.

  Organic & biomolecular chemistry 20110207

• Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis.

  International journal of medical sciences 20110101

• Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2.

  Vascular cell 20110101

• Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.

  International journal of critical illness and injury science 20110101

• Oocyte numbers in the mouse increase after treatment with 5-aminoisoquinolinone: a potent inhibitor of poly(ADP-ribosyl)ation.

  Biology of reproduction 20100501

• PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice.

  PloS one 20100101

• Inhibition of matrix metalloproteinase-2 by PARP inhibitors.

  Biochemical and biophysical research communications 20091002

• Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells.

  Pathology oncology research : POR 20090901

• Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury.

  Archives of pharmacal research 20090701

• Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells.

  Pathobiology : journal of immunopathology, molecular and cellular biology 20090501

• Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging.

  Aging 20090501

• Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

  Journal of medicinal chemistry 20090212

• Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischemia and after reperfusion.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201

• Bench-to-bedside review: latest results in hemorrhagic shock.

  Critical care (London, England) 20080101

• [Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29].

  Ai zheng = Aizheng = Chinese journal of cancer 20070601

• 5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats.

  Journal of clinical periodontology 20070201

• Therapeutic effect of a poly(ADP-ribose) polymerase-1 inhibitor on experimental arthritis by downregulating inflammation and Th1 response.

  PloS one 20070101

• Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.

  Biochemical and biophysical research communications 20061201

• Possible role of poly(ADP-ribose) polymerase in pathological and physiological cardiac hypertrophy.

  Methods and findings in experimental and clinical pharmacology 20061201

• Protective effects of PARP inhibition on liver microcirculation and function after haemorrhagic shock and resuscitation in male rats.

  Intensive care medicine 20061001

• Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction.

  Mutation research 20050502

• Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.

  The Journal of pharmacology and experimental therapeutics 20050501

• Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20050301

• Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.

  The Journal of pharmacology and experimental therapeutics 20050201

• Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs.

  The Journal of pharmacology and experimental therapeutics 20041201

• 5-Aminoisoquinolinone reduces colon injury by experimental colitis.

  Naunyn-Schmiedeberg's archives of pharmacology 20041201

• Effects of inhibition of poly(adenosine diphosphate-ribose) synthase on acute cardiac allograft rejection.

  Transplantation 20040915

• Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion.

  European journal of pharmacology 20040525

• 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion.

  Kidney international 20040201

• 5-Aminoisoquinolinone, a novel inhibitor of poly(adenosine disphosphate-ribose) polymerase, reduces microvascular liver injury but not mortality rate after hepatic ischemia-reperfusion.

  Critical care medicine 20040201

• Hepatic microcirculation in ischemia/reperfusion: is there a role for poly(adenosine 5'-diphosphate-ribose) polymerases?

  Critical care medicine 20040201

• The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.

  Medical science monitor : international medical journal of experimental and clinical research 20021101

• Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.

  Biochemical pharmacology 20020115

• 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size.

  European journal of pharmacology 20011026