93957-55-2 | sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$9.00	$6.00
50mg	95%	in stock	$16.00	$11.00
100mg	95%	in stock	$29.00	$20.00
250mg	95%	in stock	$56.00	$39.00
1g	95%	in stock	$105.00	$74.00
5g	95%	in stock	$249.00	$175.00
10g	95%	in stock	$355.00	$248.00
25g	95%	in stock	$541.00	$379.00
100g	95%	in stock	$1,224.00	$857.00

Description

• Catalog Number: AB74269
• Chemical Name: sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
• CAS Number: 93957-55-2
• Molecular Formula: C24H26FNNaO4
• Molecular Weight: 434.4557132
• MDL Number: MFCD00929076
• SMILES: OC(=O)C[C@H](C[C@H](/C=C/c1c(c2ccc(cc2)F)c2c(n1C(C)C)cccc2)O)O.[Na]

Computed Properties

• Complexity: 596
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8

Literature

• Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study.

  Vascular pharmacology 20171201

• Drug-Induced Acute Liver Injury Within 12 Hours After Fluvastatin Therapy.

  American journal of therapeutics 20160101

• Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20140901

• Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms.

  The FEBS journal 20140801

• Statins modulate transcriptional activity of heme-oxygenase-1 promoter in NIH 3T3 Cells.

  Journal of cellular biochemistry 20121101

• Dried blood spot analysis of an iron chelator--deferasirox and its potential application to therapeutic drug monitoring.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121015

• Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.

  Blood 20121011

• Statin-dependent activation of protein kinase Cδ in acute promyelocytic leukemia cells and induction of leukemic cell differentiation.

  Leukemia & lymphoma 20120901

• Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression.

  Oncology reports 20120901

• Transcriptome analysis and in vivo activity of fluvastatin versus zoledronic acid in a murine breast cancer metastasis model.

  Molecular pharmacology 20120901

• An open-label randomized controlled study of pegylated interferon/ribavirin combination therapy for chronic hepatitis C with versus without fluvastatin.

  Journal of viral hepatitis 20120901

• Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension.

  American journal of respiratory cell and molecular biology 20120801

• Chronic cough as a complication of treatment with statins: a case report.

  Therapeutic advances in respiratory disease 20120801

• Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1α in vascular smooth muscle cells.

  Cardiovascular research 20120715

• Terminalia arjuna enhances baroreflex sensitivity and myocardial function in isoproterenol-induced chronic heart failure rats.

  Journal of cardiovascular pharmacology and therapeutics 20120601

• Osteoprotegerin as a predictor of renal and cardiovascular outcomes in renal transplant recipients: follow-up data from the ALERT study.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20120601

• Fluvastatin suppresses native and recombinant human P2X4 receptor function.

  Purinergic signalling 20120601

• In vitro and in vivo susceptibility of two-drug and three-drug combinations of terbinafine, itraconazole, caspofungin, ibuprofen and fluvastatin against Pythium insidiosum.

  Veterinary microbiology 20120525

• EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin.

  Molecular and cellular biochemistry 20120501

• Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells.

  International journal of cardiology 20120405

• Fluvastatin inhibits angiotensin II-induced nuclear factor kappa B activation in renal tubular epithelial cells through the p38 MAPK pathway.

  Molecular biology reports 20120401

• The transcription factor Krüppel homolog 1 is linked to the juvenile hormone-dependent maturation of sexual behavior in the male moth, Agrotis ipsilon.

  General and comparative endocrinology 20120401

• The effects of low-dose fluvastatin and valsartan combination on arterial function: a randomized clinical trial.

  European journal of internal medicine 20120401

• Risk factors for cardiovascular events in Japanese patients treated with fluvastatin from the long-term event monitoring (LEM) study.

  Current vascular pharmacology 20120301

• Fluvastatin-induced alterations of skeletal muscle function in hypercholesterolaemic rats.

  Journal of muscle research and cell motility 20120301

• The interaction between fluvastatin and warfarin.

  International journal of cardiology 20120223

• Risk factor levels, risk factor combinations, and residual coronary risk: population-based estimates for secondary prevention patients using statins.

  European journal of preventive cardiology 20120201

• The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model.

  European journal of pharmacology 20120105

• Graft loss risk in renal transplant recipients with metabolic syndrome: subgroup analyses of the ALERT trial.

  Journal of nephrology 20120101

• [Focal myositis as a side effect of antilipidemics - 2 patients with involvement of the forearm].

  Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... 20120101

• Low-dose fluvastatin prevents the functional alterations of endothelium induced by short-term cholesterol feeding in rabbit carotid artery.

  TheScientificWorldJournal 20120101

• Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel.

  Dental materials journal 20120101

• Selected statins produce rapid spinal motor neuron loss in vitro.

  BMC musculoskeletal disorders 20120101

• The difference in pharmacokinetics and pharmacodynamics between extended-release fluvastatin and immediate-release fluvastatin in healthy Chinese subjects.

  Journal of biomedicine & biotechnology 20120101

• Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.

  PloS one 20120101

• Lipid-lowering effect of fluvastatin in relation to cytochrome P450 2C9 variant alleles frequently distributed in the Czech population.

  Medical science monitor : international medical journal of experimental and clinical research 20120101

• A survey of the FDA's AERS database regarding muscle and tendon adverse events linked to the statin drug class.

  PloS one 20120101

• In vitro quantitative ((1))H and ((19))F nuclear magnetic resonance spectroscopy and imaging studies of fluvastatin™ in Lescol® XL tablets in a USP-IV dissolution cell.

  Journal of controlled release : official journal of the Controlled Release Society 20111220

• Safety and efficacy of early aggressive versus cholesterol-driven lipid-lowering strategies in heart transplantation: a pilot, randomized, intravascular ultrasound study.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20111201

• Pilot trial of bone-targeted therapy combining zoledronate with fluvastatin or atorvastatin for patients with metastatic renal cell carcinoma.

  Clinical genitourinary cancer 20111201

• Fatal rhabdomyolysis in a patient with liver cirrhosis after switching from simvastatin to fluvastatin.

  Journal of Korean medical science 20111201

• Antiatherogenic effects of oleanolic acid in apolipoprotein E knockout mice.

  European journal of pharmacology 20111130

• Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP).

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111120

• Low-dosage statins reduce choroidal damage in hypercholesterolemic rabbits.

  Acta ophthalmologica 20111101

• Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide.

  Heart and vessels 20111101

• Protective effect of dietary tocotrienols against infection and inflammation-induced hyperlipidemia: an in vivo and in silico study.

  Phytotherapy research : PTR 20111101

• Inflammation-associated graft loss in renal transplant recipients.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101

• Fluvastatin modulates renal water reabsorption in vivo through increased AQP2 availability at the apical plasma membrane of collecting duct cells.

  Pflugers Archiv : European journal of physiology 20111101

• Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells.

  Cancer biology & therapy 20111015

• Combination of fluvastatin and losartan relieves atherosclerosis and macrophage infiltration in atherosclerotic plaques in rabbits.

  Acta pharmacologica Sinica 20111001

• Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways.

  Anticancer research 20111001

• Fluvastatin downregulates VEGF-A expression in TNF-α-induced retinal vessel tortuosity.

  Investigative ophthalmology & visual science 20110927

• Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders.

  Pharmacological research 20110901

• Interactions between organic anions on multiple transporters in Caco-2 cells.

  Journal of pharmaceutical sciences 20110901

• Effects of statin treatment on endothelial function, oxidative stress and inflammation in patients with arterial hypertension and normal cholesterol levels.

  Journal of hypertension 20110901

• Effects of fluvastatin on insulin resistance and cardiac morphology in hypertensive patients.

  Journal of human hypertension 20110801

• Effect of acetaminophen and fluvastatin on post-dose symptoms following infusion of zoledronic acid.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110801

• Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro.

  Journal of thrombosis and haemostasis : JTH 20110801

• pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.

  Molecular pharmaceutics 20110801

• Potentially new isobaric metabolite of fluvastatin observed by LC-MS/MS during incurred sample analysis.

  Bioanalysis 20110801

• Theoretical study of hydrogen bond interactions of fluvastatin with ι-carrageenan and λ-carrageenan.

  Journal of molecular modeling 20110701

• Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women.

  Bone 20110701

• Fluvastatin reduces the high mobility group box 1 protein expression in hyperlipidemia.

  International journal of cardiology 20110701

• [Pharmaco-economic optimization of cholesterol-lowering treatment with statins].

  Medicina clinica 20110625

• Statins and prostate cancer diagnosis and grade in a veterans population.

  Journal of the National Cancer Institute 20110608

• The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4.

  Molecular biology reports 20110601

• [After bypass surgery nearly all lipids are in the normal range. However, Lp(a) is too high, what can be done?].

  MMW Fortschritte der Medizin 20110526

• [Research on the effect of statins on insulin secretion from pancreatic islet in rats and its mechanisms].

  Zhonghua nei ke za zhi 20110501

• [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].

  Nihon rinsho. Japanese journal of clinical medicine 20110501

• Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome.

  Annals of the rheumatic diseases 20110401

• Subtherapeutic, low-dose fluvastatin improves functional and morphological arterial wall properties in apparently healthy, middle-aged males--a pilot study.

  Atherosclerosis 20110401

• Implant-induced intraperitoneal inflammatory angiogenesis is attenuated by fluvastatin.

  Clinical and experimental pharmacology & physiology 20110401

• Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: the Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS).

  Atherosclerosis 20110401

• [Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced ventricular arrhythmias in rats].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110401

• Involvement of Rac GTPase activation in phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to ICAM-1.

  Biochemical and biophysical research communications 20110311

• Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats.

  Cardiovascular toxicology 20110301

• Effect of long term, non cholesterol lowering dose of fluvastatin treatment on oxidative stress in brain and peripheral tissues of streptozotocin-diabetic rats.

  European journal of pharmacology 20110301

• Regulation of the endothelial plasminogen activator system by fluvastatin. Role of Rho family proteins, actin polymerisation and p38 MAP kinase.

  Thrombosis and haemostasis 20110301

• A novel use of oxidative coupling reactions for determination of some statins (cholesterol-lowering drugs) in pharmaceutical formulations.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110301

• Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats.

  Acta pharmacologica Sinica 20110301

• Deteriorating effect of fluvastatin on the cholestatic liver injury induced by bile duct ligation in rats.

  General physiology and biophysics 20110301

• Overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis triggered by fluvastatin.

  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20110301

• Inhibition of intestinal cholesterol absorption might explain cholesterol-lowering effect of telmisartan.

  Journal of clinical pharmacy and therapeutics 20110201

• The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals.

  European journal of pharmacology 20110125

• Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats.

  Behavioural brain research 20110101

• Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival.

  Haematologica 20110101

• Long-term event monitoring study of fluvastatin in Japanese patients with hypercholesterolemia: Efficacy and incidence of cardiac and other events in elderly patients (≥ 65 years old).

  Journal of cardiology 20110101

• Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.

  Journal of atherosclerosis and thrombosis 20110101

• Comparative study between high-dose fluvastatin and low-dose fluvastatin and ezetimibe with regard to the effect on endothelial function in diabetic patients.

  Endocrine journal 20110101

• [Chiral separation of fluvastatin enantiomers with in vitro cellular method].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20110101

• Fluvastatin attenuates myocardial interstitial fibrosis and cardiac dysfunction in diabetic rats by inhibiting over-expression of connective tissue growth factor.

  Chinese medical journal 20110101

• Potential benefit of statin therapy for dyslipidemia with chronic kidney disease: Fluvastatin Renal Evaluation Trial (FRET).

  Internal medicine (Tokyo, Japan) 20110101

• Effects of multiple factorial intervention on ambulatory BP profile and renal function in hypertensive type 2 diabetic patients with overt nephropathy - a pilot study.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20110101

• Fluvastatin increases bone mineral density in postmenopausal women.

  Fukushima journal of medical science 20110101

• Rhabdomyolysis secondary to hyponatraemia.

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

• Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis.

  PloS one 20110101

• Low-dose rosuvastatin improves arterial stiffness in high-risk Japanese patients with dyslipdemia in a primary prevention group.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

• Appreciating the medical literature: five notable articles in general internal medicine from 2009 and 2010.

  Open medicine : a peer-reviewed, independent, open-access journal 20110101

• Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study.

  Acta biochimica Polonica 20110101

• Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents.

  International journal of cancer 20101215

• Fluvastatin and cisplatin demonstrate synergistic cytotoxicity in epithelial ovarian cancer cells.

  Gynecologic oncology 20101201

• Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

  Atherosclerosis 20101201

• [Effects of celecoxib combined with fluvastatin on tumor growth and cell apoptosis in a xenograft model of hepatocellular carcinoma].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20101201

• Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway.

  Indian journal of experimental biology 20101201

• [Fluvastatin's effect on atherogenesis in apolipoprotein-E knockout mice infected by cytomegalovirus].

  Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 20101201

• The phototoxicity of fluvastatin, an HMG-CoA reductase inhibitor, is mediated by the formation of a benzocarbazole-like photoproduct.

  Toxicological sciences : an official journal of the Society of Toxicology 20101101

• Effects of add-on fluvastatin therapy in patients with chronic proteinuric nephropathy on dual renin-angiotensin system blockade: the ESPLANADE trial.

  Clinical journal of the American Society of Nephrology : CJASN 20101101

• Effect of sodium bicarbonate as a pharmaceutical formulation excipient on the interaction of fluvastatin with membrane phospholipids.

  European biophysics journal : EBJ 20101101

• Effect of fluvastatin, lovastatin, nifedipine and verapamil on the systemic exposure of nateglinide in rabbits.

  Biopharmaceutics & drug disposition 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Endovascular repair of abdominal aortic aneurysm.

  The New England journal of medicine 20101007

• Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20101001

• Effects of statins on vascular endothelial function in hypercholesterolemic patients with type 2 diabetes mellitus: fluvastatin vs. rosuvastatin.

  International journal of cardiology 20100924

• The effect of statin therapy on arterial stiffness by measuring pulse wave velocity: a systematic review.

  Current vascular pharmacology 20100901

• Safety of fluvastatin in patients undergoing high-risk non-cardiac surgery.

  Expert opinion on drug safety 20100901

• A randomised determination of the Effect of Fluvastatin and Atorvastatin on top of dual antiplatelet treatment on platelet aggregation after implantation of coronary drug-eluting stents. The EFA-Trial.

  Thrombosis and haemostasis 20100901

• Effects of HMG-CoA reductase inhibitors on continuous post-inflammatory vascular remodeling late after Kawasaki disease.

  Journal of cardiology 20100901

• Rhabdomyolysis induced by co-administration of fluvastatin and colchicine.

  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20100901

• Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance.

  The Journal of biological chemistry 20100716

• Serial coronary CT angiography-verified changes in plaque characteristics as an end point: evaluation of effect of statin intervention.

  JACC. Cardiovascular imaging 20100701

• Sample size calculations I.

  BMJ (Clinical research ed.) 20100616

• Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20100601

• Rhabdomyolysis and acute kidney injury secondary to concomitant use of fluvastatin and rapamycin in a renal transplant recipient.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100601

• The inhibitory effect of statins on urinary 11-dehydrothromboxane levels.

  International angiology : a journal of the International Union of Angiology 20100601

• Induced expression of lectin-like oxidized ldl receptor-1 in vascular smooth muscle cells following Chlamydia pneumoniae infection and its down-regulation by fluvastatin.

  Acta microbiologica et immunologica Hungarica 20100601

• Effects of fluvastatin therapy on serum interleukin-18 and interleukin-10 levels in patients with acute coronary syndrome.

  Acta cardiologica 20100601

• Local application of fluvastatin improves peri-implant bone quantity and mechanical properties: a rodent study.

  Acta biomaterialia 20100401

• Fluvastatin as an adjuvant to pegylated interferon and ribavirin in HIV/hepatitis C virus genotype 1 co-infected patients: an open-label randomized controlled study.

  The Journal of antimicrobial chemotherapy 20100401

• The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia.

  Biomaterials 20100401

• Effect of an antimicrobial agent on atherosclerotic plaques: assessment of metalloproteinase activity by molecular imaging.

  Journal of the American College of Cardiology 20100323

• In vivo effects of fluvastatin on HCV replication in HIV-1 coinfected subjects.

  Journal of viral hepatitis 20100301

• Does fluvastatin favour HCV replication in vivo? A pilot study on HIV-HCV co-infected patients.

  Journal of viral hepatitis 20100301

• A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.

  Journal of lipid research 20100301

• Modulation of impact of high fat diet in pathological and physiological left ventricular cardiac hypertrophy by fluvastatin.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100301

• Differential effects of fluvastatin alone or in combination with ezetimibe on lipoprotein subfractions in patients at high risk of coronary events.

  European journal of clinical investigation 20100301

• Fluvastatin attenuates diabetes-induced cardiac sympathetic neuropathy in association with a decrease in oxidative stress.

  Circulation journal : official journal of the Japanese Circulation Society 20100301

• Statins and hepatitis C virus: friend or foe?

  Hepatology (Baltimore, Md.) 20100101

• Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer.

  Breast cancer research and treatment 20100101

• Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein.

  Gynecologic oncology 20100101

• Fluvastatin/fenofibrate vs. simvastatin/ezetimibe in patients with metabolic syndrome: different effects on LDL-profiles.

  European journal of clinical investigation 20100101

• Bovine beta-lactoglobulin acts as an acid-resistant drug carrier by exploiting its diverse binding regions.

  Biological chemistry 20100101

• Role of cellular cholesterol in pharmacologic preconditioning with cyclosporine in experimental kidney transplantation.

  American journal of nephrology 20100101

• Oral fluvastatin reduces the severity of peritoneal adhesions in rats.

  Acta chirurgica Belgica 20100101

• Fluvastatin increases tyrosinase synthesis induced by alpha-melanocyte-stimulating hormone in B16F10 melanoma cells.

  Pharmacological reports : PR 20100101

• Fluvastatin in the first-line therapy of acute coronary syndrome: results of the multicenter, randomized, double-blind, placebo-controlled trial (the FACS-trial).

  Trials 20100101

• Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.

  Journal of experimental & clinical cancer research : CR 20100101

• Combined inhibitory effects of celecoxib and fluvastatin on the growth of human hepatocellular carcinoma xenografts in nude mice.

  The Journal of international medical research 20100101

• Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions.

  Pharmacological reports : PR 20100101

• Mechanism of statin-induced contractile dysfunction in rat cultured skeletal myofibers.

  Journal of pharmacological sciences 20100101

• Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201

• Fluvastatin in patients undergoing vascular surgery.

  The New England journal of medicine 20091126

• Fluvastatin in patients undergoing vascular surgery.

  The New England journal of medicine 20091126

• Novel enzyme-linked immunosorbent assay for determination of fluvastatin in plasma at picogram level.

  Talanta 20091115

• In-vitro release kinetics and stability of anticardiovascular drugs-intercalated layered double hydroxide nanohybrids.

  The journal of physical chemistry. B 20091112

• Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes.

  Basic & clinical pharmacology & toxicology 20091101

• Drug-induced liver injury associated with statins.

  Seminars in liver disease 20091101

• HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy.

  Investigative ophthalmology & visual science 20091001

• Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation.

  Atherosclerosis 20091001

• A response to the letter regarding the pleiotropic effects of fluvastatin on acute inflammatory response and the role of MMP-9 in plaque destabilization and intraplaque hemorrhage.

  Atherosclerosis 20091001

• Validation of a fast liquid chromatography-UV method for the analysis of drugs used in combined cardiovascular therapy in human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001

• Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.

  Pharmacogenomics 20091001

• Evaluation of plaque stabilization by fluvastatin with carotid intima- medial elasticity measured by a transcutaneous ultrasonic-based tissue characterization system.

  Journal of atherosclerosis and thrombosis 20091001

• Fluvastatin and perioperative events in patients undergoing vascular surgery.

  The New England journal of medicine 20090903

• In vitro interaction between suramin and fluvastatin against clinically important Zygomycetes.

  Mycoses 20090901

• Statins for the treatment of antiphospholipid syndrome?

  Annals of the New York Academy of Sciences 20090901

• Pretreatment evaluation and its application on palm oil mill effluent for bio-hydrogen enhancement and methanogenic activity repression.

  Pakistan journal of biological sciences : PJBS 20090815

• Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090801

• Vertical bone augmentation with fluvastatin in an injectable delivery system: a rat study.

  Clinical oral implants research 20090801

• Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-gamma in HaCaT cells, a human keratinocyte cell line.

  British journal of pharmacology 20090801

• No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

  British journal of clinical pharmacology 20090801

• [The effect of valsartan and fluvastatin on the connective tissue growth factor expression in experimental diabetic cardiomyopathy].

  Zhonghua nei ke za zhi 20090801

• Does fluvastatin favour HCV replication in vivo? A pilot study on HIV-HCV coinfected patients.

  Journal of viral hepatitis 20090701

• Effect of fluvastatin on progression of coronary atherosclerotic plaque evaluated by virtual histology intravascular ultrasound.

  JACC. Cardiovascular interventions 20090701

• Can statins alter coronary plaque composition assessed by radiofrequency backscatter intravascular ultrasound?

  JACC. Cardiovascular interventions 20090701

• Pharmacokinetic drug interaction between fexofenadine and fluvastatin mediated by organic anion-transporting polypeptides in rats.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628

• Cholesterol biosynthesis modulation regulates dengue viral replication.

  Virology 20090620

• In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum.

  Veterinary microbiology 20090612

• Fluvastatin accelerates re-endothelialization impaired by local sirolimus treatment.

  European journal of pharmacology 20090610

• Fluvastatin/fenofibrate vs. simvastatin/ezetimibe in patients with metabolic syndrome: different effects on LDL-profiles.

  European journal of clinical investigation 20090601

• Bisoprolol and fluvastatin for the reduction of perioperative cardiac mortality and myocardial infarction in intermediate-risk patients undergoing noncardiovascular surgery: a randomized controlled trial (DECREASE-IV).

  Annals of surgery 20090601

• Conversion to tacrolimus and atorvastatin in cyclosporine-treated heart transplant recipients with dyslipidemia refractory to fluvastatin.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090601

• Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells.

  Life sciences 20090522

• Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action.

  International journal of molecular medicine 20090501

• Efficacy and safety of Monascus purpureus Went rice in children and young adults with secondary hyperlipidemia: a preliminary report.

  European journal of internal medicine 20090501

• Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression.

  British journal of pharmacology 20090401

• Effect of fluvastatin on cardiac outcomes in kidney transplant patients with systemic lupus erythematosus: a randomized placebo-controlled study.

  Arthritis and rheumatism 20090401

• Lysophosphatidylcholine increases Na+/Ca2+ exchanger expression via RhoB-geranylgeranylation in H9c2 cells.

  Journal of pharmacological sciences 20090401

• Statins and fibrate target ClC-1 - from side effects to CLC pharmacology.

  British journal of pharmacology 20090401

• The protective effect of fluvastatin on hydroxyl radical generation by inhibiting low-density lipoprotein (LDL) oxidation in the rat myocardium.

  Microvascular research 20090301

• Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.

  Arteriosclerosis, thrombosis, and vascular biology 20090301

• Fluvastatin attenuates severe hemorrhagic shock-induced organ damage in rats.

  Resuscitation 20090301

• Novel biodegradable polyester poly(propylene succinate): synthesis and application in the preparation of solid dispersions and nanoparticles of a water-soluble drug.

  AAPS PharmSciTech 20090301

• Reduced P-selectin in hearts pretreated with fluvastatin: a novel benefit for patients undergoing open heart surgery.

  The Thoracic and cardiovascular surgeon 20090301

• [Statin therapy and muscle disorders].

  Orvosi hetilap 20090208

• Statin use in chronic heart failure: waiting for the results of large prospective outcome trials.

  International journal of cardiology 20090206

• Fluvastatin reduces pulmonary vein spontaneous activity through nitric oxide pathway.

  Journal of cardiovascular electrophysiology 20090201

• Enantioselectivity in the pharmacokinetic interaction between fluvastatin and lercanidipine in healthy volunteers.

  Journal of clinical pharmacology 20090201

• Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?

  Metabolism: clinical and experimental 20090201

• Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension.

  Journal of hypertension 20090201

• [Effects of fluvastatin on the activation of p38 mitogen-activated protein kinase in glomerular mesangial cells under high concentration of glucose].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090201

• Cerebrovascular events in renal transplant recipients.

  Transplantation 20090115

• Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice.

  Cancer research 20090115

• Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level.

  European journal of pharmacology 20090114

• Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies.

  Biomedical chromatography : BMC 20090101

• Different galenic formulations of fluvastatin have equal lipid-lowering potential but differ in reducing lipemia-induced endothelial dysfunction.

  Coronary artery disease 20090101

• Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.

  Journal of pharmacological sciences 20090101

• Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report.

  Cardiovascular diabetology 20090101

• The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.

  BMC cardiovascular disorders 20090101

• Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.

  BMC cancer 20090101

• [The effect of statin treatment on inflammation in patients with metabolic syndrome].

  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20090101

• Human cardiac fibroblasts express B-type natriuretic peptide: fluvastatin ameliorates its up-regulation by interleukin-1alpha, tumour necrosis factor-alpha and transforming growth factor-beta.

  Journal of cellular and molecular medicine 20090101

• An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype 1b in high viral loads.

  Intervirology 20090101

• Improvement in chemical and physical stability of fluvastatin drug through hydrogen bonding interactions with different polymer matrices.

  Current drug delivery 20090101

• Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

  Modern rheumatology 20090101

• Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens.

  Immunopharmacology and immunotoxicology 20090101

• Metabolic syndrome and cardiovascular risk in renal transplant recipients: effects of statin treatment.

  Clinical transplantation 20090101

• Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.

  Folia histochemica et cytobiologica 20090101

• Lovastatin and fluvastatin reduce viremia and the pro-inflammatory cytokines in the patients with chronic hepatitis C.

  Hepato-gastroenterology 20090101

• Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.

  Drug metabolism and disposition: the biological fate of chemicals 20081201

• Intensive lipid-lowering therapy for patients with aortic stenosis.

  The American journal of cardiology 20081201

• Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.

  Journal of the American College of Cardiology 20081125

• The influence of statin medications on prostate-specific antigen levels.

  Journal of the National Cancer Institute 20081105

• Beneficial effects of fluvastatin on liver microcirculation and regeneration after massive hepatectomy in rats.

  Digestive diseases and sciences 20081101

• Short-term effects of fluvastatin therapy on plasma interleukin-10 levels in patients with chronic heart failure.

  Coronary artery disease 20081101

• Fluvastatin, rhabdomyolysis, and myotoxicity.

  Mayo Clinic proceedings 20081101

• Stimulatory effects of low-dose 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor fluvastatin on hepatocyte growth factor-induced angiogenesis: involvement of p38 mitogen-activated protein kinase.

  Hypertension research : official journal of the Japanese Society of Hypertension 20081101

• Effect of statins on fibroblasts from human nasal polyps and turbinates.

  European annals of allergy and clinical immunology 20081101

• Toll-like receptor-4 is expressed in meningiomas and mediates the antiproliferative action of paclitaxel.

  International journal of cancer 20081015

• DFT study on hydroxy acid-lactone interconversion of statins: the case of atorvastatin.

  Organic & biomolecular chemistry 20081007

• HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.

  Cardiovascular research 20081001

• Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a high-fat diet in rabbits.

  Nutrition (Burbank, Los Angeles County, Calif.) 20081001

• Phase II study of metronomic chemotherapy with thalidomide, carboplatin-vincristine-fluvastatin in the treatment of brain stem tumors in children.

  Archives of medical research 20081001

• Inhibitory effects of NO-fluvastatin on proliferation of human lens epithelial cells in vitro by modulating cell cycle regulatory proteins.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001

• Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication.

  Liver international : official journal of the International Association for the Study of the Liver 20080901

• The human paraoxonase-1 phenotype modifies the effect of statins on paraoxonase activity and lipid parameters.

  British journal of clinical pharmacology 20080901

• Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention.

  International journal of cancer 20080901

• Effect of fluvastatin on serum prohepcidin levels in patients with end-stage renal disease.

  Clinical biochemistry 20080901

• Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice.

  Metabolic brain disease 20080901

• Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy.

  Pharmacogenomics 20080901

• [Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina].

  Zhonghua xin xue guan bing za zhi 20080901

• Correlates of LDL-cholesterol goal attainment in patients under lipid lowering therapy.

  Atherosclerosis 20080801

• Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program.

  Clinical pharmacology and therapeutics 20080801

• Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.

  British journal of pharmacology 20080801

• In-vitro synergism of m-TOR inhibitors, statins, and classical chemotherapy: potential implications in acute leukemia.

  Anti-cancer drugs 20080801

• Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.

  Cancer investigation 20080801

• Chiral separation of fluvastatin enantiomers by capillary electrophoresis.

  Archives of pharmacal research 20080801

• Fluvastatin in the prevention of renal transplant vasculopathy: results of a prospective, randomized, double-blind, placebo-controlled trial.

  Transplantation 20080715

• Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression.

  Molecular pharmacology 20080701

• [Effects of fluvastatin on the expression of Janus kinase 2/signal transducers and activators of transcription (JAK/STAT) in glomerular mesangial cells under high concentration of glucose].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20080701

• Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro.

  Life sciences 20080620

• Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-beta(1)/Smad 7 expression in the spontaneously hypertensive rats.

  European journal of pharmacology 20080610

• Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2.

  Arteriosclerosis, thrombosis, and vascular biology 20080601

• Efficacy and safety of Monascus purpureus Went rice in subjects with secondary hyperlipidemia.

  Clinical and experimental nephrology 20080601

• Fluvastatin inhibits hepatitis C replication in humans.

  The American journal of gastroenterology 20080601

• Topical application of statin affects bone healing around implants.

  Clinical oral implants research 20080601

• The use of fluvastatin in cardiovascular risk management.

  Expert opinion on pharmacotherapy 20080601

• HCV replication and statin pleotropism: an adjuvant treatment panacea?

  The American journal of gastroenterology 20080601

• [Pleiotropic effects of statins].

  Revista medica de Chile 20080601

• Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat.

  European journal of pharmacology 20080531

• Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers.

  Journal of the American College of Cardiology 20080506

• Statin and stromal cell-derived factor-1 additively promote angiogenesis by enhancement of progenitor cells incorporation into new vessels.

  Stem cells (Dayton, Ohio) 20080501

• The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.

  Pharmacogenetics and genomics 20080501

• Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model.

  International journal of molecular medicine 20080501

• Fluvastatin improves arterial stiffness in patients with coronary artery disease and hyperlipidemia: a 5-year follow-up study.

  Circulation journal : official journal of the Japanese Circulation Society 20080501

• Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome.

  International heart journal 20080501

• Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080423

• Fluvastatin potentiates the activity of caspofungin against Aspergillus fumigatus in vitro.

  Diagnostic microbiology and infectious disease 20080401

• Regulation of the PTEN promoter by statins and SREBP.

  Human molecular genetics 20080401

• Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.

  Journal of thrombosis and haemostasis : JTH 20080401

• Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study.

  Pharmacogenetics and genomics 20080401

• Lipid levels and low-density lipoprotein cholesterol goal attainment in diabetic patients: rosuvastatin compared with other statins in usual care.

  Expert opinion on pharmacotherapy 20080401

• [Influence of statins on the antiplatelet effect of clopidogrel and on cardiovascular outcome in patients after coronary intervention].

  Deutsche medizinische Wochenschrift (1946) 20080401

• Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure.

  International journal of cardiology 20080220

• Efficacy and tolerability of fluvastatin XL 80 mg alone, ezetimibe alone, and the combination of fluvastatin XL 80 mg with ezetimibe in patients with a history of muscle-related side effects with other statins.

  The American journal of cardiology 20080215

• Determination of two HMG-CoA reductase inhibitors, pravastatin and pitavastatin, in plasma samples using liquid chromatography-tandem mass spectrometry for pharmaceutical study.

  Biomedical chromatography : BMC 20080201

• Impact of systemic hypertension on the cardiovascular benefits of statin therapy--a meta-analysis.

  The American journal of cardiology 20080201

• The effects of short term statin treatment on left ventricular function and inflammatory markers in patients with chronic heart failure.

  International journal of cardiology 20080111

• [Fluvastatin induces apoptosis on human tongue carcinoma cell line HSC-3].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080101

• Molecular modeling of two CYP2C19 SNPs and its implications for personalized drug design.

  Protein and peptide letters 20080101

• Effects of fluvastatin extended-release (80 mg) alone and in combination with ezetimibe (10 mg) on low-density lipoprotein cholesterol and inflammatory parameters in patients with primary hypercholesterolemia: a 12-week, multicenter, randomized, open-label, parallel-group study.

  Clinical therapeutics 20080101

• Fluvastatin treatment and withdrawal: effects on endothelial function.

  Angiology 20080101

• Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.

  Clinical pharmacokinetics 20080101

• Rab-small GTPases are involved in fluvastatin and pravastatin-induced vacuolation in rat skeletal myofibers.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071201

• Immediate effect of fluvastatin on lipid levels in acute coronary syndrome.

  Molecular and cellular biochemistry 20071201

• Delayed postischemic treatment with fluvastatin improved cognitive impairment after stroke in rats.

  Stroke 20071201

• Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions.

  Acta pharmacologica Sinica 20071201

• Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics.

  Atherosclerosis 20071001

• Fluvastatin inhibits hypoxic proliferation and p38 MAPK activity in pulmonary artery fibroblasts.

  American journal of respiratory cell and molecular biology 20071001

• Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones.

  Cardiovascular research 20071001

• Effect of fluvastatin on vascular endothelial growth factor in rats with osteoporosis in process of fracture healing.

  Chinese journal of traumatology = Zhonghua chuang shang za zhi 20071001

• Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion.

  Journal of cardiovascular pharmacology 20071001

• Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients.

  Journal of lipid research 20070901

• Fluvastatin blunts the effect of a high-fat meal on plasma triglyceride and high-sensitivity C-reactive protein concentrations in patients at high risk for cardiovascular events.

  Coronary artery disease 20070901

• Marked elevation of liver transaminases after high-dose fluvastatin unmasks chronic hepatitis C: safety and re-challenge.

  Acta neurologica Taiwanica 20070901

• Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice.

  The American journal of geriatric pharmacotherapy 20070901

• Risk reduction and tolerability of fluvastatin in patients with the metabolic syndrome: a pooled analysis of thirty clinical trials.

  Clinical therapeutics 20070901

• Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

  Drug metabolism and disposition: the biological fate of chemicals 20070801

• Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues.

  The Biochemical journal 20070801

• Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways.

  Cancer research 20070801

• Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.

  Journal of the American College of Cardiology 20070731

• The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.

  European journal of pharmacology 20070730

• Effect of statin withdrawal on frequency of cardiac events after vascular surgery.

  The American journal of cardiology 20070715

• Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro.

  Breast cancer research and treatment 20070701

• Fluvastatin ameliorates endotoxin induced multiple organ failure in conscious rats.

  Resuscitation 20070701

• Simvastatin and fluvastatin reduce interleukin-6 and interleukin-8 lipopolysaccharide (LPS) stimulated production by isolated human monocytes from chronic kidney disease patients.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20070701

• Effect of fluvastatin and valsartan, alone and in combination, on postprandial vascular inflammation and fibrinolytic activity in patients with essential hypertension.

  Journal of cardiovascular pharmacology 20070701

• Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase.

  Arteriosclerosis, thrombosis, and vascular biology 20070601

• Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction.

  Clinical immunology (Orlando, Fla.) 20070601

• Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis.

  Arthritis and rheumatism 20070601

• Time-of-intake (morning versus evening) of extended-release fluvastatin in hyperlipemic patients is without influence on the pharmacodynamics (mevalonic acid excretion) and pharmacokinetics.

  International journal of clinical pharmacology and therapeutics 20070601

• Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system.

  The Journal of pharmacology and experimental therapeutics 20070501

• HIV envelope protein gp120-triggered CD4+ T-cell adhesion to vascular endothelium is regulated via CD4 and CXCR4 receptors.

  Biochimica et biophysica acta 20070501

• Autoimmune hepatitis after treatment with fluvastatin.

  Liver international : official journal of the International Association for the Study of the Liver 20070501

• Effect of paraoxonase 1 polymorphisms on the response of lipids and lipoprotein-associated enzymes to treatment with fluvastatin.

  Archives of medical research 20070501

• Effect of clopidogrel on the steady-state pharmacokinetics of fluvastatin.

  Journal of clinical pharmacology 20070501

• Suppressive effects of statins on acute promyelocytic leukemia cells.

  Cancer research 20070501

• Effect of HMGCoA reductase inhibitors on cytochrome P450 expression in endothelial cell line.

  Journal of cardiovascular pharmacology 20070501

• Efficacy and safety of extended-release fluvastatin in Turkish patients with hypercholesterolaemia: TULIPS (Turkish Lipid Study).

  Current medical research and opinion 20070501

• The effect of fluvastatin on cardiac outcomes in patients with moderate to severe renal insufficiency: a pooled analysis of double-blind, randomized trials.

  International journal of cardiology 20070412

• 3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design.

  Biochemical and biophysical research communications 20070406

• Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylation.

  Atherosclerosis 20070401

• Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin.

  Pharmacological research 20070401

• Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma.

  Leukemia research 20070301

• Pravastatin inhibits arrhythmias induced by coronary artery ischemia in anesthetized rats.

  Journal of pharmacological sciences 20070301

• Fluvastatin as co-medication in heart transplant recipients with elevated creatine-kinase.

  Transplantation proceedings 20070301

• Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects.

  Lipids 20070301

• Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells.

  European journal of pharmacology 20070205

• Fluvastatin reduced liver injury in rat model of extrahepatic cholestasis.

  Pediatric surgery international 20070201

• Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis.

  International immunology 20070201

• [Effect of fluvastatin extended release on the protein-lipid structure of erythrocyte membrane and C-reactive protein in patients with hyperlipidemia].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070201

• Fluvastatin and cancer.

  International journal of clinical practice 20070101

• Effects of statins on restenosis after coronary stent implantation.

  Angiology 20070101

• HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells.

  Journal of vascular research 20070101

• Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.

  Japanese journal of ophthalmology 20070101

• [Influence of valsartan, fluvastatin extended release and their combination on arterial pressure, parameters of lipid metabolism, and endothelial function in patients with hypertensive disease].

  Kardiologiia 20070101

• Novel 'plum pudding' gels as potential drug-eluting stent coatings: controlled release of fluvastatin.

  Journal of biomedical materials research. Part A 20061215

• DFT study on hydroxy acid-lactone interconversion of statins: The case of fluvastatin.

  Organic & biomolecular chemistry 20061207

• Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration.

  Biomaterials 20061201

• Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy.

  The Journal of pharmacology and experimental therapeutics 20061201

• Pharmacokinetic interaction between fluvastatin and diltiazem in rats.

  Biopharmaceutics & drug disposition 20061201

• Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study.

  British journal of pharmacology 20061201

• Early administration of fluvastatin, but not at the onset of ischemia or reperfusion, attenuates myocardial ischemia-reperfusion injury through the nitric oxide pathway rather than its antioxidant property.

  Circulation journal : official journal of the Japanese Circulation Society 20061201

• The effect of fluvastatin on cICAM-1 as a biomarker of endothelial dysfunction in patients with dyslipidemia.

  International angiology : a journal of the International Union of Angiology 20061201

• Efficacy and safety of fluvastatin in children and adolescents with heterozygous familial hypercholesterolaemia.

  Acta paediatrica (Oslo, Norway : 1992) 20061101

• Toxicity of statins on rat skeletal muscle mitochondria.

  Cellular and molecular life sciences : CMLS 20061001

• SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin.

  Clinical pharmacology and therapeutics 20061001

• Neutrophil superoxide anion generation during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention.

  Journal of cardiovascular pharmacology 20061001

• Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.

  Journal of cardiovascular pharmacology 20061001

• Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer.

  World journal of gastroenterology 20060921

• Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains.

  Neuropharmacology 20060901

• Fluvastatin treatment is not associated with an increased incidence of cancer.

  International journal of clinical practice 20060901

• Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells.

  Molecular cancer therapeutics 20060901

• HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1.

  Life sciences 20060829

• Renal transplant dysfunction--importance quantified in comparison with traditional risk factors for cardiovascular disease and mortality.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801

• The cost-effectiveness of fluvastatin in Hungary following successful percutaneous coronary intervention.

  Cardiovascular drugs and therapy 20060801

• Effects of statins on experimental colitis in normocholesterolemic rats.

  Scandinavian journal of gastroenterology 20060801

• Fluvastatin alters psychomotor performance and daily activity but not the spatial memory in rats.

  The Tohoku journal of experimental medicine 20060801

• Ezetimibe effectively decreases LDL-cholesterol in HIV-infected patients.

  AIDS (London, England) 20060801

• Chronic fluvastatin treatment alters vascular contraction by inhibiting the Rho/Rho-kinase pathway.

  Clinical and experimental pharmacology & physiology 20060801

• Statins, especially atorvastatin, may improve survival following brachytherapy for clinically localized prostate cancer.

  Urologic nursing 20060801

• Healing unhealthy Hungarian hearts--at what cost?--With what benefit?

  Cardiovascular drugs and therapy 20060801

• Inhibitory effects of statins on human monocarboxylate transporter 4.

  International journal of pharmaceutics 20060706

• Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth.

  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20060701

• Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.

  International journal of oncology 20060701

• Different anti-HCV profiles of statins and their potential for combination therapy with interferon.

  Hepatology (Baltimore, Md.) 20060701

• Management of cardiovascular risk in patients receiving calcineurin inhibitors--a case report.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701

• Persistence and adherence to cholesterol lowering agents: evidence from Régie de l'Assurance Maladie du Québec data.

  American heart journal 20060701

• Column-switching high-performance liquid chromatographic analysis of fluvastatin in rat plasma by direct injection.

  Journal of pharmaceutical and biomedical analysis 20060616

• Protective effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on copper-induced hydroxyl radical generation in the rat heart.

  Toxicology 20060615

• The effect of different doses of fluvastatin on inflammatory markers in the early phase of acute coronary syndrome.

  Clinica chimica acta; international journal of clinical chemistry 20060601

• Effect of low-density lipoprotein cholesterol on angiotensin II sensitivity: a randomized trial with fluvastatin.

  Hypertension (Dallas, Tex. : 1979) 20060601

• TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells.

  Vascular pharmacology 20060601

• Use of an indirect effect model to describe the LDL cholesterol-lowering effect by statins in hypercholesterolaemic patients.

  Fundamental & clinical pharmacology 20060601

• Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin.

  European journal of clinical pharmacology 20060601

• The clinical relevance of low-density-lipoproteins size modulation by statins.

  Cardiovascular drugs and therapy 20060601

• Management of dyslipidemia in renal disease and transplantation.

  Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 20060601

• Effect of fluvastatin on apolipoprotein-defined lipoprotein subclasses in patients with chronic renal insufficiency.

  Kidney international 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The effect of fluvastatin on plasma adiponectin levels in dyslipidaemia.

  Clinical endocrinology 20060501

• Effect of lipid levels and lipid-lowering therapy on restenosis after coronary artery stenting.

  The American journal of the medical sciences 20060501

• Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints.

  Reviews on recent clinical trials 20060501

• Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro.

  Biochemical pharmacology 20060428

• Fluvastatin increases heterotopically induced ossicles in mice.

  Clinical and experimental pharmacology & physiology 20060401

• Evaluation of the pharmacokinetic interaction between fluvastatin XL and cyclosporine in renal transplant recipients.

  International journal of clinical pharmacology and therapeutics 20060401

• Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients with allergic asthma.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060401

• Chiral evaluation of fluvastatin in human plasma by high-performance liquid chromatography electrospray mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307

• The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia.

  Atherosclerosis 20060301

• Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling.

  Journal of the American Society of Nephrology : JASN 20060301

• Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction.

  Journal of the American Geriatrics Society 20060301

• The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours.

  Endocrine-related cancer 20060301

• Use of hydroxy-methyl-glutaryl coenzyme A reductase inhibitors is associated with risk of lymphoid malignancies.

  Cancer science 20060201

• Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis.

  Arthritis and rheumatism 20060201

• [Statins in patients with kidney failure: efficacy, tolerance, and prescription guidelines in patients with chronic kidney disease and renal transplant].

  Presse medicale (Paris, France : 1983) 20060201

• C-reactive protein-induced upregulation of extracellular matrix metalloproteinase inducer in macrophages: inhibitory effect of fluvastatin.

  Life sciences 20060125

• Folate co-administration improves the effectiveness of fenofibrate to decrease the lipoprotein oxidation and endothelial dysfunction surrogates.

  Physiological research 20060101

• Statins and osteoporosis: new role for old drugs.

  The Journal of pharmacy and pharmacology 20060101

• Inhibitory effects of amlodipine and fluvastatin on the deposition of advanced glycation end products in aortic wall of cholesterol and fructose-fed rabbits.

  Biological & pharmaceutical bulletin 20060101

• Ezetimibe for the treatment of uncontrolled hypercholesterolemia in patients with high-dose statin therapy after renal transplantation.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060101

• Fluvastatin does not elevate periosteal osteogenesis induce by Moloney sarcoma virus (MSV) in mice.

  Pharmacological reports : PR 20060101

• Liquid chromatography/negative ion electrospray tandem mass spectrometry method for the quantification of fluvastatin in human plasma: validation and its application to pharmacokinetic studies.

  Rapid communications in mass spectrometry : RCM 20060101

• A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.

  Neoplasma 20060101

• Zoledronic acid (Zometa) enhances the cytotoxic effect of gemcitabine and fluvastatin: in vitro isobologram studies with conventional and nonconventional cytotoxic agents.

  Oncology 20060101

• Efficacy and safety of fluvastatin-extended release in hypercholesterolemic patients: morning administration is equivalent to evening administration.

  Cardiology 20060101

• Cost-effectiveness analysis of cholesterol-lowering therapies in Spain.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

• Influence of fluvastatin on bone formation induced by demineralized bone matrix in mice.

  Pharmacological reports : PR 20060101

• Fluvastatin prevents oxidized low-density lipoprotein-induced injury of renal tubular epithelial cells by inhibiting the phosphatidylinositol 3-kinase/Akt-signaling pathway.

  Journal of nephrology 20060101

• The renal safety profile of fluvastatin: results of a pooled analysis.

  Renal failure 20060101

• No detrimental effect on renal function during long-term use of fluvastatin in renal transplant recipients in the Assessment of Lescol in Renal Transplantation (ALERT) study.

  Clinical transplantation 20060101

• Fluvastatin and hepatic reactions: a signal from spontaneous reporting in Italy.

  Drug safety 20060101

• Preventive effect of fluvastatin on ulcerative colitis-associated carcinogenesis in mice.

  Anticancer research 20060101

• The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome.

  The Journal of membrane biology 20060101

• Effects of fluvastatin on the carotid arterial media as assessed by integrated backscatter ultrasound compared with pulse-wave velocity.

  Journal of the American College of Cardiology 20051206

• Long-term cardiac outcomes in renal transplant recipients receiving fluvastatin: the ALERT extension study.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051201

• [Fluvastatin-induced dermatomyositis].

  Annales de dermatologie et de venereologie 20051201

• Does time of onset of therapy alter the protective cardiovascular effect of fluvastatin after renal transplantation?

  Nature clinical practice. Nephrology 20051201

• EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer.

  Biochemical pharmacology 20051125

• Focal seizures after treatment with fluvastatin in a patient with a history of catastrophic antiphospholipid syndrome.

  Journal of the neurological sciences 20051115

• The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells.

  The Journal of surgical research 20051101

• Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension.

  Arteriosclerosis, thrombosis, and vascular biology 20051101

• Statin-induced apoptosis linked with membrane farnesylated Ras small G protein depletion, rather than geranylated Rho protein.

  The Journal of pharmacy and pharmacology 20051101

• Differential associations of statin and fibrate treatment with carotid arterial remodeling.

  American journal of hypertension 20051101

• Statin toxicity: a situation that mimics viral hepatitis.

  International journal of clinical pharmacology and therapeutics 20051101

• In-hospital initiation of statin therapy in acute coronary syndromes: maximizing the early and long-term benefits.

  Chest 20051101

• Comparison of efficacy and safety assessment of fluvastatin in patients <65 years versus > or =65 years of age.

  The American journal of cardiology 20051015

• Persistence and determinants of statin therapy among middle-aged patients free of cardiovascular disease.

  European journal of clinical pharmacology 20051001

• [Early intervention on atherosclerosis by fluvastatin and lectin-like oxidized low-density lipoprotein receptor-1 expression in atherosclerotic arteries in immature rabbits].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20051001

• The long-term course of low-density lipoprotein cholesterol after initiation of statin treatment: retrospective database analysis over 3 years in health maintenance organization enrollees.

  Clinical therapeutics 20051001

• [Fluvastatin affects HLA class I expression on endothelial cells].

  Nephrologie & therapeutique 20051001

• Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry.

  Journal of pharmaceutical and biomedical analysis 20050915

• Binding thermodynamics of statins to HMG-CoA reductase.

  Biochemistry 20050906

• Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050901

• Long-term effects of antilipidaemic therapy on left ventricular function in patients with dyslipidaemia: multigated radionuclide ventriculography study.

  Nuclear medicine communications 20050901

• Does fluvastatin really have an antioxidant effect in humans?

  Kidney international 20050901

• Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates.

  Journal of cardiovascular pharmacology 20050901

• Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia.

  Metabolism: clinical and experimental 20050901

• Cardiovascular risk and renal transplantation: post hoc analyses of the Assessment of Lescol in Renal Transplantation (ALERT) Study.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20050901

• Fluvastatin: efficacy and safety in reducing cardiac events.

  Expert opinion on pharmacotherapy 20050901

• Differences between statins on clinical endpoints: a population-based cohort study.

  Current medical research and opinion 20050901

• [Influence of fluvastatin on left ventricular remodeling after myocardial infarction in rats].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050901

• Regulation of connexin expression after balloon injury: possible mechanisms for antiproliferative effect of statins.

  American journal of hypertension 20050901

• Effects of fluvastatin, an HMG-CoA reductase inhibitor, on serum levels of interleukin-18 and matrix metalloproteinase-9 in patients with hypercholesterolemia.

  Clinical cardiology 20050901

• Decreased heart rate recovery in patients with heart failure: effect of fluvastatin therapy.

  International heart journal 20050901

• A cost-effectiveness analysis of fluvastatin in patients with diabetes after successful percutaneous coronary intervention.

  Clinical therapeutics 20050901

• Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells.

  British journal of cancer 20050808

• Down-regulation of Na+/Ca2+ exchanger by fluvastatin in rat cardiomyoblast H9c2 cells: involvement of RhoB in Na+/Ca2+ exchanger mRNA stability.

  Molecular pharmacology 20050801

• Effect of atorvastatin and fluvastatin on the metabolism of midazolam by cytochrome P450 in vitro.

  Anaesthesia 20050801

• The effect of fluvastatin on the pharmacokinetics and pharmacodynamics of ezetimibe.

  Current medical research and opinion 20050801

• Not all statins interfere with clopidogrel during antiplatelet therapy.

  European journal of clinical investigation 20050801

• Efficacy and safety of slow-release fluvastatin 80 mg daily in Chinese patients with hypercholesterolemia.

  Journal of the Chinese Medical Association : JCMA 20050801

• Polymorphonuclear leukocytes may impair endothelial function: results of crossover randomized study of lipid-lowering therapies.

  Arteriosclerosis, thrombosis, and vascular biology 20050601

• Clinical practice guidelines for managing dyslipidemias in kidney transplant patients: lessons to be learnt from the assessment of Lescol in renal transplantation (ALERT) trial.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050601

• Clinical practice guidelines for managing dyslipidemias in kidney transplant patients.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050601

• Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia.

  Journal of vascular surgery 20050601

• Induction of micronuclei in CHO cells by bleomycin but not by X-irradiation is decreased by treatment with HMG-CoA reductase inhibitors.

  Journal of radiation research 20050601

• Effect of fluvastatin on apoptosis in human CD4+ T cells.

  Cellular immunology 20050601

• A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis.

  Journal of the American College of Cardiology 20050517

• Renal dysfunction as a risk factor for mortality and cardiovascular disease in renal transplantation: experience from the Assessment of Lescol in Renal Transplantation trial.

  Transplantation 20050515

• Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats.

  Cancer letters 20050510

• Beneficial effect of early initiation of lipid-lowering therapy following renal transplantation.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050501

• Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression on human endothelial cells.

  Annals of vascular surgery 20050501

• Fluvastatin plus fish oil are more effective on cardiovascular risk factors than fluvastatin alone.

  Prostaglandins, leukotrienes, and essential fatty acids 20050501

• Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the -786T>C polymorphism.

  Pharmacogenetics and genomics 20050501

• More on: fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells.

  Journal of thrombosis and haemostasis : JTH 20050501

• A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial.

  Mayo Clinic proceedings 20050501

• Immediate effects of fluvastain on circulating soluble endothelial protein C and free tissue factor pathway inhibitor in acute coronary syndromes.

  Cardiovascular drugs and therapy 20050501

• Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050426

• Fluvastatin prevents renal injury and expression of lactin-like oxidized low-density lipoprotein receptor-1 in rabbits with hypercholesterolemia.

  Chinese medical journal 20050420

• Renoprotective effect of combining angiotensin II receptor blockers and statins in diabetic rats.

  Chinese medical journal 20050405

• Endothelial dysfunction and hypercontractility of vascular myocytes are ameliorated by fluvastatin in obese Zucker rats.

  American journal of physiology. Heart and circulatory physiology 20050401

• Cost-effectiveness of fluvastatin following successful first percutaneous coronary intervention.

  The Annals of pharmacotherapy 20050401

• Fluvastatin ameliorates the hyperhomocysteinemia-induced endothelial dysfunction: the antioxidative properties of fluvastatin.

  Circulation journal : official journal of the Japanese Circulation Society 20050401

• In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors.

  Pharmaceutical research 20050401

• Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients.

  Endocrine journal 20050401

• [Effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, lipid peroxidation, and aortic atherosclerosis in hypercholesterolemic rabbits].

  Arquivos brasileiros de cardiologia 20050401

• [Effects of fluvastatin on blood levels of inflammatory cytokines in patients with unstable angina undergoing percutaneous coronary intervention].

  Zhonghua xin xue guan bing za zhi 20050401

• Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.

  Journal of leukocyte biology 20050301

• Fluvastatin inhibits the expression of tumor necrosis factor-alpha and activation of nuclear factor-kappaB in human endothelial cells stimulated by C-reactive protein.

  Clinica chimica acta; international journal of clinical chemistry 20050301

• More on: Fluvastatin inhibits upregulation of tissue factor expression by antiphospholipid antibodies on endothelial cells.

  Journal of thrombosis and haemostasis : JTH 20050301

• [The effect of early fluvastatin therapy on inflammatory factors in acute coronary syndrome].

  Zhonghua nei ke za zhi 20050301

• Fluvastatin reduces the 4-year cardiac risk in patients with multivessel disease.

  International journal of cardiology 20050227

• Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug.

  World journal of gastroenterology 20050221

• [Comparative study of effects of fluvastatin and losartan on left ventricular remodeling in rat myocardial infarction].

  Zhonghua yi xue za zhi 20050216

• Long-term fluvastatin reduces the hazardous effect of renal impairment on four-year atherosclerotic outcomes (a LIPS substudy).

  The American journal of cardiology 20050215

• Long-term effects of statins on arterial pressure and stiffness of hypertensives.

  Journal of human hypertension 20050201

• Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan.

  Journal of clinical pharmacy and therapeutics 20050201

• Fluvastatin and lifestyle modification for reduction of carotid intima-media thickness and left ventricular mass progression in drug-treated hypertensives.

  Atherosclerosis 20050201

• Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies.

  Thrombosis and haemostasis 20050201

• No effect of fluvastatin on the bone mineral density of children with minimal change glomerulonephritis and some focal mesangial cell proliferation, other than an ameliorating effect on their proteinuria.

  Clinical nephrology 20050201

• A review of the lipid-related effects of fluvastatin.

  Current medical research and opinion 20050201

• Revascularization of coronary atherosclerosis in patients with diabetes mellitus--there is more to it than meets the image intensifier.

  American heart journal 20050201

• Fluvastatin reduces the impact of diabetes on long-term outcome after coronary intervention--a Lescol Intervention Prevention Study (LIPS) substudy.

  American heart journal 20050201

• Risk factors for reaching renal endpoints in the assessment of Lescol in renal transplantation (ALERT) trial.

  Transplantation 20050127

• Quantitative determination of fluvastatin in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry using [18O2]-fluvastatin as an internal standard.

  Rapid communications in mass spectrometry : RCM 20050101

• A comparative crossover study of the effects of fluvastatin and pravastatin (FP-COS) on circulating autoantibodies to oxidized LDL in patients with hypercholesterolemia.

  Journal of atherosclerosis and thrombosis 20050101

• Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy.

  Drug safety 20050101

• [Pilot study of the noninvasive assessment of endothelial dysfunction by post-occlusion dopplerometry velocity curves analysis in arteria brachialis].

  Casopis lekaru ceskych 20050101

• Possible colchicine rhabdomyolysis in a fluvastatin-treated patient.

  The Annals of pharmacotherapy 20050101

• Fluvastatin in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation.

  Renal failure 20050101

• Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells.

  BMC cardiovascular disorders 20050101

• Considerations in the treatment of dyslipidemia associated with chronic kidney failure and renal transplantation.

  Preventive cardiology 20050101

• [Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on antioxidative enzymatic activity].

  Wiadomosci lekarskie (Warsaw, Poland : 1960) 20050101

• Enhancement of MMP-9 activity in THP-1 cells by 7-ketocholesterol and its suppression by the HMG-CoA reductase inhibitor fluvastatin.

  Journal of atherosclerosis and thrombosis 20050101

• [Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on lipid peroxidation].

  Wiadomosci lekarskie (Warsaw, Poland : 1960) 20050101

• Effects of fluvastatin slow-release (XL 80 mg) versus simvastatin (20 mg) on the lipid triad in patients with type 2 diabetes.

  Advances in therapy 20050101

• Effects of fluvastatin treatment on lipid profile, C-reactive protein trend, and renal function in dyslipidemic patients with chronic renal failure.

  Advances in therapy 20050101

• Monitoring of peripheral blood cytotoxic T-cells under fluvastatin treatment in renal transplant recipients.

  Journal of biological regulators and homeostatic agents 20050101

• Expression of serum and glucocorticoid-inducible kinase1 in diabetic rats and its modulation by fluvastatin.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

• 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041215

• Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.

  Biochemistry 20041214

• HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation.

  Cardiovascular research 20041201

• Relapse of respiratory insufficiency one year after organising pneumonia.

  The European respiratory journal 20041201

• Fluvastatin reduces oxidative stress, decreases serum monocyte chemotactic protein-1 level and improves endothelial function in patients with hypercholesterolemia.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20041201

• Inhibitory effect of statins on the proliferation of human breast cancer cells.

  International journal of clinical pharmacology and therapeutics 20041201

• Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery: rationale and design of the DECREASE-IV study.

  American heart journal 20041201

• Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention.

  Platelets 20041201

• Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells.

  Journal of cellular biochemistry 20041115

• Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.

  Hypertension (Dallas, Tex. : 1979) 20041101

• Effects of statins on circulating oxidized low-density lipoprotein in patients with hypercholesterolemia.

  Japanese heart journal 20041101

• Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis.

  Journal of immunology (Baltimore, Md. : 1950) 20041015

• Beneficial effects of fluvastatin following percutaneous coronary intervention in patients with unstable and stable angina: results from the Lescol intervention prevention study (LIPS).

  Heart (British Cardiac Society) 20041001

• Effect of fluvastatin on renal end points in the Assessment of Lescol in Renal Transplant (ALERT) trial.

  Kidney international 20041001

• Immunosuppression in human peripheral blood T lymphocytes by fluvastatin.

  Acta biochimica et biophysica Sinica 20041001

• Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial.

  Clinical therapeutics 20041001

• Is decreased libido associated with the use of HMG-CoA-reductase inhibitors?

  British journal of clinical pharmacology 20040901

• Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells.

  Journal of thrombosis and haemostasis : JTH 20040901

• Fluvastatin and fluvastatin extended release: a clinical and safety profile.

  Expert review of cardiovascular therapy 20040901

• Impact of fluvastatin on hyperlipidemia after renal transplantation.

  Transplantation proceedings 20040901

• Statin blocks Rho/Rho-kinase signalling and disrupts the actin cytoskeleton: relationship to enhancement of LPS-mediated nitric oxide synthesis in vascular smooth muscle cells.

  Biochimica et biophysica acta 20040804

• Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir.

  Infection 20040801

• Statin decreases endothelial microparticle release from human coronary artery endothelial cells: implication for the Rho-kinase pathway.

  Biochemical and biophysical research communications 20040716

• An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates.

  Drug metabolism and disposition: the biological fate of chemicals 20040701

• Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively.

  The American journal of cardiology 20040701

• Safety and efficacy of fluvastatin in hyperlipidemic patients with chronic renal disease.

  Renal failure 20040701

• Statins contribute to enhancement of the number and the function of endothelial progenitor cells from peripheral blood.

  Sheng li xue bao : [Acta physiologica Sinica] 20040625

• [Not just decreased LDL level is decisive. Which statin for patients at risk for coronary disease?].

  MMW Fortschritte der Medizin 20040610

• [Despite coronary intervention, the risk remains high: PCI patients need additional protection].

  MMW Fortschritte der Medizin 20040610

• [Type 2 diabetic: risk same as after infarct. With LDL not only the quantity counts].

  MMW Fortschritte der Medizin 20040610

• fluvastatin prevents cardiac death and myocardial infarction in renal transplant recipients: post-hoc subgroup analyses of the ALERT Study.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040601

• Fluvastatin improves endothelial dysfunction in overweight postmenopausal women through small dense low-density lipoprotein reduction.

  Metabolism: clinical and experimental 20040601

• Effect of fluvastatin therapy on coronary flow reserve in patients with hypercholesterolemia.

  The American journal of cardiology 20040601

• Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis.

  Hypertension (Dallas, Tex. : 1979) 20040601

• Update on statins.

  Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing 20040601

• Effects of statins on oxidative stress.

  Biological trace element research 20040501

• Class-specific pro-apoptotic effect of statins on human vascular endothelial cells.

  Zeitschrift fur Kardiologie 20040501

• Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.

  DNA and cell biology 20040501

• [Statin-induced rhabdomyolysis and renal failure: also with fluvastatine].

  Anales de medicina interna (Madrid, Spain : 1984) 20040501

• The use of statins in optimising reduction of cardiovascular risk: focus on fluvastatin.

  International journal of clinical practice 20040501

• Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.

  Biochemical and biophysical research communications 20040409

• ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles.

  American journal of physiology. Heart and circulatory physiology 20040401

• Efficacy and safety of fluvastatin therapy for hypercholesterolemia after heart transplantation: results of a randomised double blind placebo controlled study.

  International journal of cardiology 20040401

• Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.

  Biochemical and biophysical research communications 20040312

• Steady-state pharmacokinetics of fluvastatin in healthy subjects following a new extended release fluvastatin tablet, Lescol XL.

  Biopharmaceutics & drug disposition 20040301

• Fluvastatin slow-release lowers platelet-activating factor acetyl hydrolase activity: a placebo-controlled trial in patients with type 2 diabetes.

  The Journal of clinical endocrinology and metabolism 20040301

• [Effects of angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase inhibitors, amlodipine and epalrestat on cultured basilar artery smooth muscle cell proliferation].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301

• Lipid-lowering effects of ethyl 2-phenacyl-3-aryl-1H-pyrrole- 4-carboxylates in rodents.

  Molecules (Basel, Switzerland) 20040227

• Hydroxymethyl-glutaryl coenzyme a reductase inhibition limits cytomegalovirus infection in human endothelial cells.

  Circulation 20040203

• Chronic treatment with fluvastatin improves smooth muscle dilatory function in genetically determined hyperlipoproteinemia.

  Journal of cardiovascular pharmacology 20040201

• Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement-mediated acute inflammation.

  Clinical and experimental immunology 20040201

• Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation.

  Experimental and molecular pathology 20040201

• Plasma antioxidative activity during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention.

  Fundamental & clinical pharmacology 20040201

• Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial.

  International journal of cardiology 20040201

• Oral anticoagulant drug interactions with statins: case report of fluvastatin and review of the literature.

  Pharmacotherapy 20040201

• Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytes.

  Atherosclerosis 20040201

• Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin.

  Atherosclerosis 20040201

• Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats.

  Pediatric nephrology (Berlin, Germany) 20040101

• Effect of 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities.

  Journal of cardiovascular pharmacology 20040101

• Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects.

  The American journal of cardiology 20040101

• Effect of fluvastatin on long-term outcome after coronary revascularization with stent implantation.

  The American journal of cardiology 20040101

• Relationship between hypercholesterolemia, lipid-lowering therapy and coronary flow velocity reserve evaluated by stress transesophageal echocardiography in patients with a negative coronary angiogram.

  Echocardiography (Mount Kisco, N.Y.) 20040101

• Pharmacokinetics and lipid-lowering effect of fluvastatin in hypercholesterolaemic patients on maintenance haemodialysis.

  The Journal of international medical research 20040101

• Fluvastatin reduces cardiac mortality in patients with coronary heart disease.

  Cardiovascular drugs and therapy 20040101

• The influence of statins on the free intracellular calcium concentration in human umbilical vein endothelial cells.

  BMC cardiovascular disorders 20040101

• Effects of fluvastatin in type 2 diabetic patients with hyperlipidemia: reduction in cholesterol oxidation products and VCAM-1.

  Journal of atherosclerosis and thrombosis 20040101

• Effects of fluvastatin on endothelium-derived hyperpolarizing factor- and nitric oxide-mediated relaxations in arteries of hypertensive rats.

  Clinical and experimental pharmacology & physiology 20040101

• Fluvastatin: clinical and safety profile.

  Drugs 20040101

• Lichenoid drug eruption with HMG-CoA reductase inhibitors (fluvastatin and lovastatin).

  Acta dermato-venereologica 20040101

• An economic evaluation of fluvastatin used for the prevention of cardiac events following successful first percutaneous coronary intervention in the UK.

  PharmacoEconomics 20040101

• Fluvastatin reduces renal fibroblast proliferation and production of type III collagen: therapeutic implications for tubulointerstitial fibrosis.

  Nephron. Experimental nephrology 20040101

• Inhibitors of differentiation/DNA binding proteins Id1 and Id3 are regulated by statins in endothelial cells.

  Endothelium : journal of endothelial cell research 20040101

• [Effects of long acting fluvastatin on parameters of lipid metabolism in patients with type 2 diabetes and combined hyperlipidemia].

  Kardiologiia 20040101

• Treatment with fluvastatin rapidly modulates, via different pathways, and in dependence on the baseline level, inflammation in hemodialysis patients.

  Blood purification 20040101

• Effect of simvastatin and fluvastatin on plasma fibrinogen levels in patients with primary hypercholesterolemia.

  Polish journal of pharmacology 20040101

• Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2.

  Molecular pharmaceutics 20040101

• A propensity score-matched cohort study of the effect of statins, mainly fluvastatin, on the occurrence of acute myocardial infarction.

  The American journal of cardiology 20031215

• Statins induce suppressor of cytokine signaling-3 in macrophages.

  FEBS letters 20031204

• Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.

  Biological & pharmaceutical bulletin 20031201

• Time-dependent lipid response on fluvastatin therapy of patients with hypercholesterolemia sensitive to apoE phenotype.

  Vascular pharmacology 20031201

• HMG-CoA reductase inhibitor, fluvastatin, has cholesterol-lowering independent 'direct' effects on atherosclerotic vessels in high cholesterol diet-fed rabbits.

  Pharmacological research 20031101

• Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model.

  Arthritis and rheumatism 20031101

• Effects of statins on adhesion molecule expression in endothelial cells.

  Journal of thrombosis and haemostasis : JTH 20031101

• Fluvastatin improves insulin resistance in nondiabetic dyslipidemic patients.

  Endocrine 20031101

• A multicenter, randomized, double-blind clinical trial comparing the low-density lipoprotein cholesterol-lowering ability of lovastatin 10, 20, and 40 mg/d with fluvastatin 20 and 40 mg/d.

  Clinical therapeutics 20031101

• Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.

  International journal of oncology 20031001

• Effects of baseline level of triglycerides on changes in lipid levels from combined fluvastatin + fibrate (bezafibrate, fenofibrate, or gemfibrozil).

  The American journal of cardiology 20031001

• Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration.

  European journal of clinical pharmacology 20030901

• Protective effect of fluvastatin, an HMG-CoA reductase inhibitor, on the formation of 8-oxo-2'-deoxyguanosine in the nuclear DNA of hamster pancreas after a single administration of N-nitrosobis(2-oxopropyl)amine.

  Biological & pharmaceutical bulletin 20030901

• A retrospective analysis of the effect of noncompliance on time to first major adverse cardiac event in LIPS.

  Clinical therapeutics 20030901

• [The expression of connective tissue growth factor in renal cortex of 5/6 nephrectomized rats and its modulation by fluvastatin].

  Zhonghua yi xue za zhi 20030825

• Fluvastatin reduces atherogenic lipids without any effect on native endothelial function early after kidney transplantation.

  Clinical transplantation 20030801

• Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers.

  Clinical pharmacology and therapeutics 20030801

• Effect of fluvastatin and dipyridamole on proteinuria and renal function in childhood IgA nephropathy with mild histological findings and moderate proteinuria.

  Clinical nephrology 20030801

• Fluvastatin attenuates nitrate tolerance in patients with ischemic heart disease complicating hypercholesterolemia.

  International journal of cardiology 20030801

• Reduction of myocardial infarct size by fluvastatin.

  American journal of physiology. Heart and circulatory physiology 20030701

• Preservation of endothelial function by the HMG-CoA reductase inhibitor fluvastatin through its lipid-lowering independent antioxidant properties in atherosclerotic rabbits.

  Pharmacology 20030701

• Preservation of endothelium-dependent and Nomega-nitro-L-arginine methyl ester- and indomethacin-resistant arterial relaxation in high-cholesterol-diet fed rabbits by treatment with fluvastatin, an HMG-CoA reductase inhibitor.

  Journal of cardiovascular pharmacology 20030701

• Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells.

  Prostaglandins & other lipid mediators 20030701

• Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial.

  Lancet (London, England) 20030614

• Cost effectiveness of statin therapy for the primary prevention of major coronary events in individuals with type 2 diabetes.

  Diabetes care 20030601

• Reduction of arteriosclerotic nanoplaque formation and size by fluvastatin in a receptor-based biosensor model.

  Cardiovascular research 20030601

• Antioxidative potential of fluvastatin via the inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.

  Biological & pharmaceutical bulletin 20030601

• Beneficial effects of fluvastatin on progressive renal allograft dysfunction.

  Transplantation proceedings 20030601

• The Lescol Intervention Prevention Study (LIPS): start all patients on statins early after PCI.

  Cleveland Clinic journal of medicine 20030601

• Serum lipid comparison in patients treated by statins or fibrates: existence of bad HDL-C responders to statins.

  Acta cardiologica 20030601

• The effect of an HMG-CoA reductase inhibitor on arteriosclerotic nanoplaque formation and size in a biosensor model.

  Biosensors & bioelectronics 20030501

• Effect of a 3-year therapy with the 3-hydroxy-3-methylglutaryl coenzyme a reductase-inhibitor fluvastatin on endothelial function and distensibility of large arteries in hypercholesterolemic renal transplant recipient.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20030501

• Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia.

  American heart journal 20030501

• [Treatment of hypercholesterolemia in kidney transplant recipients].

  Deutsche medizinische Wochenschrift (1946) 20030417

• [Better prognosis for dialysis dependent type 2 diabetic patient. Statin delays arterial onset of arterial stiffness].

  MMW Fortschritte der Medizin 20030417

• Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins.

  Molecular pharmacology 20030401

• Vascular smooth muscle cell activation by C-reactive protein.

  Cardiovascular research 20030401

• Randomized, double-blind, placebo-controlled comparison of the action of orlistat, fluvastatin, or both an anthropometric measurements, blood pressure, and lipid profile in obese patients with hypercholesterolemia prescribed a standardized diet.

  Clinical therapeutics 20030401

• [Effect of fluvastatin and fenofibrate on reactive oxygen species generation and lipid peroxidation in patients with dyslipidemia].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030401

• [Effect of fluvastatin and fenofibrate on the antioxidative barrier enzyme activity in patients with dyslipidemia].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030401

• The sorry saga of the statins in New Zealand--pharmacopolitics versus patient care.

  The New Zealand medical journal 20030314

• Response from PHARMAC: difficult choices.

  The New Zealand medical journal 20030314

• Treating dyslipidemia with statins: the risk-benefit profile.

  American heart journal 20030301

• Statins inhibit high glucose-mediated neutrophil-endothelial cell adhesion through decreasing surface expression of endothelial adhesion molecules by stimulating production of endothelial nitric oxide.

  Microvascular research 20030301

• Comparison of treatment with fluvastatin extended-release 80-mg tablets and immediate-release 40-mg capsules in patients with primary hypercholesterolemia.

  Clinical therapeutics 20030301

• Cytochrome P450 epoxygenases and vascular tone: novel role for HMG-CoA reductase inhibitors in the regulation of CYP 2C expression.

  Biochimica et biophysica acta 20030217

• Fluvastatin induces apoptosis of vascular endothelial cells: blockade by glucocorticoids.

  Cardiovascular surgery (London, England) 20030201

• Sensitive assay for the determination of fluvastatin in plasma utilizing high-performance liquid chromatography with fluorescence detection.

  Therapeutic drug monitoring 20030201

• Fluvastatin prevents renal dysfunction and vascular NO deficit in apolipoprotein E-deficient mice.

  Arteriosclerosis, thrombosis, and vascular biology 20030201

• Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet.

  Phytotherapy research : PTR 20030201

• Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation.

  Arquivos brasileiros de cardiologia 20030201

• Frequency of creatine kinase elevation during treatment with fluvastatin in combination with fibrates (bezafibrate, fenofibrate, or gemfibrozil).

  The American journal of cardiology 20030115

• Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation.

  Circulation 20030107

• Fluvastin therapy affects TAFI concentration in kidney transplant recipients.

  Transplant international : official journal of the European Society for Organ Transplantation 20030101

• A model to assess the cost effectiveness of statins in achieving the UK National Service Framework target cholesterol levels.

  PharmacoEconomics 20030101

• An economic analysis of the Atorvastatin Comparative Cholesterol Efficacy and Safety Study (ACCESS).

  PharmacoEconomics 20030101

• Variable influence of statins on isoprostanes in hyperlipidemia.

  Advances in experimental medicine and biology 20030101

• Short-term efficacy and safety of extended-release fluvastatin in a large cohort of elderly patients.

  The American journal of geriatric cardiology 20030101

• [Combination therapy with fluvastatin and fenofibrate in ischemic heart disease patients with combined hyperlipidemia and type 2 diabetes].

  Kardiologiia 20030101

• [High therapeutic effect and safety of fluvastatin].

  Pharmazie in unserer Zeit 20030101

• HMG CoA reductase inhibitor fluvastatin arrests the development of implanted hepatocarcinoma in rats.

  Anticancer research 20030101

• Effects of D-003, a mixture of long-chain aliphatic primary acids, fluvastatin and the combined therapy of D-003 plus fluvastatin on the lipid profile of normocholesterolemic rabbits.

  International journal of tissue reactions 20030101

• Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials.

  BMC family practice 20030101

• Fluvastatin increases LDL particle size and reduces oxidative stress in patients with hyperlipidemia.

  Journal of atherosclerosis and thrombosis 20030101

• Fluvastatin induces apoptosis in rat neonatal cardiac myocytes: a possible mechanism of statin-attenuated cardiac hypertrophy.

  Journal of cardiovascular pharmacology 20021201

• Fluvastatin-induced rhabdomyolysis.

  The Annals of pharmacotherapy 20021201

• Effect of fluvastatin slow-release on low density lipoprotein (LDL) subfractions in patients with type 2 diabetes mellitus: baseline LDL profile determines specific mode of action.

  The Journal of clinical endocrinology and metabolism 20021201

• Effect of fluvastatin on ischaemia following acute myocardial infarction: a randomized trial.

  European heart journal 20021201

• [Effects of fluvastatin on the levels of C-reactive protein and lipids in patients with hyperlipidemia].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20021201

• Time-dependent effect of statins on platelet function in hypercholesterolaemia.

  European journal of clinical investigation 20021201

• Rapid spectrophotometric method for quantitative determination of simvastatin and fluvastatin in human serum and pharmaceutical formulations.

  Die Pharmazie 20021201

• Toward a role for statins in immunomodulation.

  Molecular interventions 20021201

• Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells.

  Atherosclerosis 20021101

• Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin.

  Journal of molecular medicine (Berlin, Germany) 20021101

• Fluvastatin.

  Expert opinion on pharmacotherapy 20021101

• Stereospecific disposition of fluvastatin in streptozotocin-induced diabetic rats.

  Canadian journal of physiology and pharmacology 20021101

• Comparing the effects of five different statins on the HDL subpopulation profiles of coronary heart disease patients.

  Atherosclerosis 20021001

• Fluvastatin remodels resistance arteries in genetically hypertensive rats, even in the absence of any effect on blood pressure.

  Clinical and experimental pharmacology & physiology 20021001

• Hypercholesterolaemia and treatment with statins do not alter L-arginine-induced changes of renal haemodynamics.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20021001

• Biosensing of arteriosclerotic nanoplaque formation and interaction with an HMG-CoA reductase inhibitor.

  Acta physiologica Scandinavica 20021001

• Severe rhabdomyolysis after laparoscopic surgery for adenocarcinoma of the rectum in two patients treated with statins.

  Anesthesiology 20021001

• Antioxidative effects of fluvastatin and its metabolites against DNA damage in streptozotocin-treated mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021001

• Efficacy and safety of fluvastatin in hyperlipidemic protease inhibitor-treated HIV-infected patients.

  AIDS (London, England) 20020927

• Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in Guinea pig ventricular myocytes.

  Molecular pharmacology 20020901

• [Antilipemic agents in combined therapy].

  Orvosi hetilap 20020825

• Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatin.

  Clinical and experimental pharmacology & physiology 20020801

• Impact of treatment of dyslipidemia on renal function, fat deposits and scarring in patients with persistent nephrotic syndrome.

  Nephron 20020801

• Fluvastatin prevents development of arterial stiffness in haemodialysis patients with type 2 diabetes mellitus.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020801

• The HMG Co-A reductase inhibitors ('statins') and myotoxic effects.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20020801

• Valsartan therapy has additive anti-oxidative effect to that of fluvastatin therapy against low-density lipoprotein oxidation: studies in hypercholesterolemic and hypertensive patients.

  Journal of cardiovascular pharmacology 20020701

• Statin-induced apoptosis of vascular endothelial cells is blocked by dexamethasone.

  The Journal of endocrinology 20020701

• Cyclosporin A pharmacokinetics in a patient with psoriasis and obesity, presenting with high levels of low-density [correction for destiny] lipoprotein.

  European journal of clinical pharmacology 20020701

• [Clinical study of the month. The LIPS study: fluvastatin for prevention of cardiac events following percutaneous coronary angioplasty].

  Revue medicale de Liege 20020701

• Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial.

  JAMA 20020626

• Preventing cardiac events and restenosis after percutaneous coronary intervention.

  JAMA 20020626

• Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.

  Cardiovascular research 20020601

• Statins and risk of polyneuropathy: a case-control study.

  Neurology 20020514

• [Effects of fluvastatin on plasma lipid abnormalities in hemodialysis patients with chronic renal failure].

  Nihon Jinzo Gakkai shi 20020501

• Antioxidative effects of fluvastatin on superoxide anion activated by angiotensin II in human aortic smooth muscle cells.

  Cardiovascular drugs and therapy 20020501

• [Taking statins immediately after heart catheterization. Rate of complications is cut in half in diabetic patients].

  MMW Fortschritte der Medizin 20020404

• Effects of hypocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German cockroach.

  Archives of insect biochemistry and physiology 20020401

• Fluvastatin reduces tissue factor expression and macrophage accumulation in carotid lesions of cholesterol-fed rabbits in the absence of lipid lowering.

  Arteriosclerosis, thrombosis, and vascular biology 20020401

• Cholesterol-induced thrombogenicity of the vessel wall: inhibitory effect of fluvastatin.

  Thrombosis and haemostasis 20020401

• Managing dyslipidemia in the high-risk patient.

  The American journal of cardiology 20020307

• Pharmacokinetics of fluvastatin in subjects with renal impairment and nephrotic syndrome.

  Journal of clinical pharmacology 20020301

• [Complete remission of minimal change nephrotic syndrome with type 2 diabetes mellitus treated by microemulsion formulation of cyclosporin and fluvastatin].

  Nihon Jinzo Gakkai shi 20020301

• [Stimulation of bone formation by anti-hyperlipidemic agent statins and its mechanism of action].

  Nihon rinsho. Japanese journal of clinical medicine 20020301

• HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells.

  Cardiovascular drugs and therapy 20020301

• Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction.

  Circulation 20020219

• Fluvastatin enhances apoptosis in cytokine-stimulated vascular smooth muscle cells.

  Journal of cardiovascular pharmacology 20020201

• 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis.

  Gastroenterology 20020201

• Fluvastatin reduces modification of low-density lipoprotein in hyperlipidemic rabbit loaded with oxidative stress.

  European journal of pharmacology 20020201

• Safety and efficacy of atorvastatin in heart transplant recipients.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20020201

• Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients.

  Atherosclerosis 20020201

• Effect of fluvastatin and pravastatin, HMG-CoA reductase inhibitors, on fluconazole activity against Candida albicans.

  Journal of medical microbiology 20020201

• Electrochemical study of fluvastatin sodium--analytical application to pharmaceutical dosage forms, human serum, and simulated gastric juice.

  Analytical and bioanalytical chemistry 20020201

• Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

  FEBS letters 20020116

• Frequency of creatine kinase elevation during treatment with fluvastatin.

  The American journal of cardiology 20020115

• Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

  Biochemical and biophysical research communications 20020111

• Fluvastatin improves lipid abnormalities in patients with moderate to advanced chronic renal insufficiency.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101

• Effects of fluvastatin treatment on insulin sensitivity in patients with hyperlipidaemia.

  The Journal of international medical research 20020101

• The effect of fluvastatin on plasma fibrinogen levels.

  Current medical research and opinion 20020101

• Effects of fluvastatin on homocysteine and serum lipids in kidney allograft recipients.

  Annals of transplantation 20020101

• [Effect of fluvastain and its combination with aspirin and trental on hemostasis and microcirculation in atherosclerosis].

  Terapevticheskii arkhiv 20020101

• Acute pancreatitis induced by fluvastatin therapy.

  Journal of clinical gastroenterology 20020101

• Plasma lipids and blood fluidity in patients with polygenic hypercholesterolaemia treated with fluvastatin.

  Clinical hemorheology and microcirculation 20020101

• Neuromuscular toxicity in nephrotic patients treated with fluvastatin.

  Journal of nephrology 20020101

• Stereoselective analysis of fluvastatin in human plasma for pharmacokinetic studies.

  Journal of chromatography. B, Biomedical sciences and applications 20011205

• Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20011201

• Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype.

  Arthritis and rheumatism 20011201

• Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins.

  Annals of the New York Academy of Sciences 20011201

• Antioxidative effects of fluvastatin and its metabolites against oxidative DNA damage in mammalian cultured cells.

  Free radical research 20011201

• Fluvastatin depresses the enhanced lipid peroxidation in vitamin E-deficient hamsters.

  Free radical research 20011201

• Effect of diet and treatment with statins on platelet-dependent thrombin generation in hypercholesterolemic subjects.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20011201

• Effect of fluvastatin on acute renal allograft rejection: a randomized multicenter trial.

  Kidney international 20011101

• Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells.

  Chinese medical journal 20011101

• The use over time of statins in coronary patients in an Italian tertiary referral center.

  Italian heart journal : official journal of the Italian Federation of Cardiology 20011101

• Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis.

  Circulation 20011030

• Validated analysis of fluvastatin in a pharmaceutical capsule formulation and serum by capillary electrophoresis.

  Biomedical chromatography : BMC 20011001

• The influence of plasma lipoprotein (a) on angiographic restenosis and coronary events in patients undergoing planned coronary balloon angioplasty. Ancillary analysis of the Fluvastatin Angioplasty Restenosis (FLARE) trial.

  Atherosclerosis 20011001

• Managed care trends in statin usage.

  Managed care (Langhorne, Pa.) 20011001

• Pharmacokinetics and pharmacodynamics of fluvastatin in heart transplant recipients taking cyclosporine A.

  Journal of cardiovascular pharmacology and therapeutics 20011001

• Fluvastatin in combination with rad significantly reduces graft vascular disease in rat cardiac allografts.

  Transplantation 20010927

• Lipid-independent effects of an estrogen-statin combination: inhibition of expression of adhesion molecules and plasminogen activator inhibitor--I in human endothelial cell cultures.

  Climacteric : the journal of the International Menopause Society 20010901

• Lipophilic statins can be osteogenic by promoting osteoblastic calcification in a Cbfa1- and BMP-2-independent manner.

  Methods and findings in experimental and clinical pharmacology 20010901

• Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection.

  Journal of chromatography. B, Biomedical sciences and applications 20010825

• Achieving and maintaining National Cholesterol Education Program low-density lipoprotein cholesterol goals with five statins.

  The American journal of medicine 20010815

• Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species.

  Life sciences 20010810

• Fluvastatin inhibits O2- and ICAM-1 levels in a rat model with aortic remodeling induced by pressure overload.

  American journal of physiology. Heart and circulatory physiology 20010801

• Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

  European journal of clinical pharmacology 20010801

• Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins.

  Atherosclerosis 20010701

• Lipophilic statins augment inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes.

  Journal of cardiovascular pharmacology 20010701

• Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20010701

• Effects of fluvastatin and its major metabolites on low-density lipoprotein oxidation and cholesterol esterification in macrophages.

  Japanese journal of pharmacology 20010701

• Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors.

  Cancer research 20010615

• Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction.

  Kidney international 20010601

• HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress.

  Arteriosclerosis, thrombosis, and vascular biology 20010601

• LDL-receptor gene mutations and the hypocholesterolemic response to statin therapy.

  Clinical genetics 20010601

• Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate.

  The American journal of cardiology 20010515

• Novel polymorphisms in promoter region of atp binding cassette transporter gene and plasma lipids, severity, progression, and regression of coronary atherosclerosis and response to therapy.

  Circulation research 20010511

• Safety, tolerability, and pharmacokinetics of an extended-release formulation of fluvastatin administered once daily to patients with primary hypercholesterolemia.

  Journal of cardiovascular pharmacology 20010501

• Effects of 1-year treatment with fluvastatin or pravastatin on bone.

  The American journal of medicine 20010501

• Efficacy and safety of treatment with low-dose fluvastatin in hypercholesterolemic renal transplant recipients.

  Transplantation proceedings 20010501

• Statin induced myopathy does not show up in MIBI scintigraphy.

  Nuclear medicine communications 20010501

• A cost-effectiveness model of alternative statins to achieve target LDL-cholesterol levels.

  International journal of clinical practice 20010501

• Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart.

  Biochimica et biophysica acta 20010430

• Fluvastatin lowers atherogenic dense low-density lipoproteins in postmenopausal women with the atherogenic lipoprotein phenotype.

  Circulation 20010417

• Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: Main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS).

  Circulation 20010403

• A HMG-CoA reductase inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects--the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action.

  Atherosclerosis 20010401

• Fluvastatin therapy improves microcirculation in patients with hyperlipidaemia.

  Atherosclerosis 20010401

• Comparative study of HMG-CoA reductase inhibitors on fibrinogen.

  Atherosclerosis 20010401

• Effect of fluvastatin on endothelium-dependent brachial artery vasodilation in patients after renal transplantation.

  Kidney international 20010401

• Effects of fluvastatin on cardiac events in renal transplant patients: ALERT (Assessment of Lescol in Renal Transplantation) study design and baseline data.

  Journal of cardiovascular risk 20010401

• Dose dependency of fluvastatin pharmacokinetics in serum determined by reversed phase HPLC.

  Journal of cardiovascular pharmacology and therapeutics 20010401

• Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin.

  Toxicology letters 20010331

• Immunological response to oxidized LDL occurs in association with oxidative DNA damage independently of serum LDL concentrations in dyslipidemic patients.

  Clinica chimica acta; international journal of clinical chemistry 20010301

• Statin therapy--what now?

  Drug and therapeutics bulletin 20010301

• Effects of fluvastatin on biliary lipids in subjects with an elevated cholesterol saturation index.

  European journal of clinical pharmacology 20010301

• A comparison of the efficacy and tolerability of titrate-to-goal regimens of simvastatin and fluvastatin: a randomized, double-blind study in adult patients at moderate to high risk for cardiovascular disease.

  Clinical therapeutics 20010301

• [Fluvastatin].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• [Antioxidants].

  Nihon rinsho. Japanese journal of clinical medicine 20010301

• A clinical focus on statins.

  Current opinion in investigational drugs (London, England : 2000) 20010301

• Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits.

  Circulation 20010220

• A prospective study of paraoxonase gene Q/R192 polymorphism and severity, progression and regression of coronary atherosclerosis, plasma lipid levels, clinical events and response to fluvastatin.

  Atherosclerosis 20010215

• Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma.

  Biological & pharmaceutical bulletin 20010201

• Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes.

  The Journal of pharmacy and pharmacology 20010201

• Regulation of endothelial nitric oxide synthase and endothelin-1 expression by fluvastatin in human vascular endothelial cells.

  Japanese journal of pharmacology 20010201

• Efficacy and tolerability of fluvastatin extended-release delivery system: a pooled analysis.

  Clinical therapeutics 20010201

• [The role of HDL in the prevention of cardiovascular events].

  Orvosi hetilap 20010121

• Effective use of statins to prevent coronary heart disease.

  American family physician 20010115

• Statin trials in progress: unanswered questions.

  Current atherosclerosis reports 20010101

• New statins and new doses of older statins.

  Current atherosclerosis reports 20010101

• Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits.

  Atherosclerosis 20010101

• [Antioxidative effects of fluvastatin, and its major metabolites [II]].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101

• Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT Study)--a rebuttal.

  Thrombosis and haemostasis 20010101

• Comparison of the efficacy and tolerability of fluvastatin extended-release and immediate-release formulations in the treatment of primary hypercholesterolemia: a randomized trial.

  Clinical therapeutics 20010101

• Protective effects of fluvastatin against reactive oxygen species induced DNA damage and mutagenesis.

  Free radical research 20010101

• Effect of an estrogen/statin combination on biochemical markers of endothelial function in human coronary artery cell cultures.

  Menopause (New York, N.Y.) 20010101

• Clinical pharmacokinetics of fluvastatin.

  Clinical pharmacokinetics 20010101

• Further evidence for direct vascular actions of statins: effect on endothelial nitric oxide synthase and adhesion molecules.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101

• The effect of fluvastatin on parameters of bone remodeling.

  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20010101

• Newer HMG-CoA reductase inhibitor (statin) therapies.

  Clinical cardiology 20010101

• Synthetic statins: more data on newer lipid-lowering agents.

  Current medical research and opinion 20010101

• The effect of fluvastatin of hyperlipidemia in renal transplant recipients: a prospective, placebo-controlled study.

  International urology and nephrology 20010101

• Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT study). Fluvastatin Alone and in Combination Treatment.

  Thrombosis and haemostasis 20000401

• Statin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease.

  International journal of cardiology 19990601

• The effects of fluvastatin, a CYP2C9 inhibitor, on losartan pharmacokinetics in healthy volunteers.

  Journal of clinical pharmacology 19990401

• Two different types of exercise-induced muscle pain without myopathy and CK-elevation during HMG-Co-enzyme-A-reductase inhibitor treatment.

  Atherosclerosis 19990401

• In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans.

  Antimicrobial agents and chemotherapy 19970401

• Effect of fluvastatin or bezafibrate on the distribution of high density lipoprotein subpopulations in patients with familial hypercholesterolemia.

  Arzneimittel-Forschung 19960901

• Fluvastatin in combination with other lipid-lowering agents.

  British journal of clinical practice. Supplement 19960101

• Efficacy and safety of triple therapy (fluvastatin-bezafibrate-cholestyramine) for severe familial hypercholesterolemia.

  The American journal of cardiology 19950713

• Treatment of primary hypercholesterolemia: fluvastatin versus bezafibrate.

  The American journal of medicine 19940606

• Efficacy and safety of a combination fluvastatin-bezafibrate treatment for familial hypercholesterolemia: comparative analysis with a fluvastatin-cholestyramine combination.

  The American journal of medicine 19940501

• HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts.

  Journal of medicinal chemistry 19931112

• Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.

  Journal of medicinal chemistry 19911001

• Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.

  Journal of medicinal chemistry 19910101