950912-80-8 | PF-670462

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$19.00	$14.00
5mg	98%	in stock	$46.00	$33.00
10mg	98%	in stock	$68.00	$48.00
50mg	98%	in stock	$194.00	$136.00

Description

• Catalog Number: AW54940
• Chemical Name: PF-670462
• CAS Number: 950912-80-8
• Molecular Formula: C19H22Cl2FN5
• Molecular Weight: 410.3159
• MDL Number: MFCD12828759
• SMILES: Nc1nccc(n1)c1n(cnc1c1ccc(cc1)F)C1CCCCC1.Cl.Cl

Computed Properties

• Complexity: 422
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3

Literature

• Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.

  American journal of physiology. Renal physiology 20121001

• Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120801

• IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.

  Oncogene 20110602

• Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.

  The Journal of pharmacology and experimental therapeutics 20090801

• A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.

  Psychopharmacology 20090501

• An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions.

  The Journal of pharmacology and experimental therapeutics 20070801