951-78-0 | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$13.00	$9.00
10g	98%	in stock	$22.00	$16.00
25g	95%	in stock	$47.00	$33.00
100g	98%	in stock	$186.00	$130.00

Description

• Catalog Number: AC70869
• Chemical Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• CAS Number: 951-78-0
• Molecular Formula: C9H12N2O5
• Molecular Weight: 228.2020
• MDL Number: MFCD00006527
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O

Computed Properties

• Complexity: 343
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -1.6

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  Journal of experimental & clinical cancer research : CR 20100101

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  Clinical cancer research : an official journal of the American Association for Cancer Research 20081115

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  The American journal of pathology 20081001

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  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20080401

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  Bioorganic & medicinal chemistry letters 20080115

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  Virology journal 20080101

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  Journal of molecular recognition : JMR 20080101

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  Malaria journal 20080101

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  The international journal of biochemistry & cell biology 20080101

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• p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

  The Journal of biological chemistry 20070608

• Oligonucleotides containing 6-aza-2'-deoxyuridine: synthesis, nucleobase protection, pH-dependent duplex stability, and metal-DNA formation.

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• Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants.

  Journal of enzyme inhibition and medicinal chemistry 20060201

• Oxygen independent DNA interstrand cross-link formation by a nucleotide radical.

  Journal of the American Chemical Society 20060118

• Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide.

  Chemical research in toxicology 20060101

• Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion.

  Nutrition (Burbank, Los Angeles County, Calif.) 20060101

• Viruses take center stage in cellular evolution.

  Genome biology 20060101

• [Study of drugs against neoplastic metastasis].

  Magyar onkologia 20060101

• A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.

  Journal of experimental botany 20060101

• [Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)].

  Casopis lekaru ceskych 20060101

• Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.

  Antiviral chemistry & chemotherapy 20060101

• Nucleotide insertion opposite a cyclobutane pyrimidine dimer analogue caused from photoligation by a replicative DNA polymerase.

  Nucleic acids symposium series (2004) 20060101

• Synthesis and properties of novel PRODAN-labeled uridine.

  Nucleic acids symposium series (2004) 20060101

• [The innate antiretroviral defense of human cells, based on the DNA editing].

  Postepy biochemii 20060101

• Paradigm development: comparative and predictive 3D modeling of HIV-1 Virion Infectivity Factor (Vif).

  Bioinformation 20060101

• Synthesis of a 2'-Se-uridine phosphoramidite and its incorporation into oligonucleotides for structural study.

  Organic letters 20051208

• Comparison of Py*+/dU*- charge transfer state dynamics in 5-(1-pyrenyl)-2'-deoxyuridine nucleoside conjugates with amido-, ethylenyl-, and ethynyl linkers.

  The journal of physical chemistry. A 20051208

• Synthesis and in vitro antileishmanial activity of 5-substituted-2'-deoxyuridine derivatives.

  Bioorganic chemistry 20051201

• Yersiniophage phiR1-37 is a tailed bacteriophage having a 270 kb DNA genome with thymidine replaced by deoxyuridine.

  Microbiology (Reading, England) 20051201

• Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2'-deoxyuridine and 5-chloro-2'-deoxyuridine.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20051101

• Emx2 regulates mammalian reproduction by altering endometrial cell proliferation.

  Molecular endocrinology (Baltimore, Md.) 20051101

• Increased muscle nucleoside levels associated with a novel frameshift mutation in the thymidine phosphorylase gene in a Spanish patient with MNGIE.

  Neuromuscular disorders : NMD 20051101

• Nucleic acid with guanidinium modification exhibits efficient cellular uptake.

  Angewandte Chemie (International ed. in English) 20051021

• A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.

  British journal of cancer 20051017

• Late-onset MNGIE due to partial loss of thymidine phosphorylase activity.

  Annals of neurology 20051001

• Site-selective DNA hydrolysis by Ce(IV)-EDTA with the use of one oligonucleotide additive bearing two monophosphates.

  Chembiochem : a European journal of chemical biology 20051001

• Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target.

  Journal of medicinal chemistry 20050922

• Incorporation of cationic chains in the Dickerson-Drew dodecamer: correlation of energetics, structure, and ion and water binding.

  Biochemistry 20050920

• Electron transfer chemistry between DNA and DNA-binding tripeptides.

  Biochemistry 20050906

• The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells.

  Journal of neuro-oncology 20050901

• Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050801

• Oxidation of 5-hydroxypyrimidine nucleosides to 5-hydroxyhydantoin and its alpha-hydroxy-ketone isomer.

  Chemical research in toxicology 20050801

• Thymidine phosphorylase mutations cause instability of mitochondrial DNA.

  Gene 20050718

• Photoinduced DNA end capping via N3-methyl-5-cyanovinyl-2'-deoxyuridine.

  Chemical communications (Cambridge, England) 20050707

• Template-directed DNA photoligation via alpha-5-cyanovinyldeoxyuridine.

  Organic letters 20050707

• Mitochondrial deoxynucleotide pools in quiescent fibroblasts: a possible model for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

  The Journal of biological chemistry 20050701

• Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase.

  Structure (London, England : 1993) 20050701

• Charge transfer excited-state dynamics in DNA duplexes substituted with an ethynylpyrenyldeoxyuridine electron source and a fluorodeoxyuridine electron trap.

  The journal of physical chemistry. B 20050623

• ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.

  Biochimica et biophysica acta 20050615

• Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase.

  Journal of immunology (Baltimore, Md. : 1950) 20050615

• Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050605

• Proton affinity ladder for uridine and analogs: influence of the hydroxyl group on the sugar ring conformation.

  Journal of mass spectrometry : JMS 20050601

• A dual selection based, targeted gene replacement tool for Magnaporthe grisea and Fusarium oxysporum.

  Fungal genetics and biology : FG & B 20050601

• Structure of B-DNA with cations tethered in the major groove.

  Biochemistry 20050524

• beta-Selective synthesis of 2'-deoxy-5,6-dihydro-4-thiouridine, a precursor of the unstable nucleoside product of ionising radiation damage 2'-deoxy-5,6-dihydrocytidine.

  Organic & biomolecular chemistry 20050507

• Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.

  Current biology : CB 20050412

• Determining the origin of the stabilization of DNA by 5-aminopropynylation of pyrimidines.

  Biochemistry 20050329

• Reductive electron transfer in phenothiazine-modified DNA is dependent on the base sequence.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20050304

• Differential incorporation of halogenated deoxyuridines during UV-induced DNA repair synthesis in human cells.

  DNA repair 20050302

• Rapid identification of emerging pathogens: coronavirus.

  Emerging infectious diseases 20050301

• Phosphodiester cleavage of guanylyl-(3',3')-(2'-amino-2'-deoxyuridine): rate acceleration by the 2'-amino function.

  Journal of the American Chemical Society 20050216

• A phase II study of raltitrexed and gemcitabine in patients with advanced pancreatic carcinoma.

  British journal of cancer 20050214

• The fate of heterologous CD4+ T cells during Leishmania donovani infection.

  European journal of immunology 20050201

• dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

  Structure (London, England : 1993) 20050201

• Active site plasticity of endonuclease V from Salmonella typhimurium.

  Biochemistry 20050118

• A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells.

  Bioorganic & medicinal chemistry letters 20050103

• APOBEC3G & HTLV-1: inhibition without deamination.

  Retrovirology 20050101

• Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast.

  BMC genetics 20050101

• APOBEC3G targets human T-cell leukemia virus type 1.

  Retrovirology 20050101

• Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.

  Virology journal 20050101

• CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.

  BMC bioinformatics 20050101

• Use of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy.

  Retrovirology 20050101

• Megaloblastosis: from morphos to molecules.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101

• Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines.

  Nucleosides, nucleotides & nucleic acids 20050101

• Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomono phosphate as a potential thymidylate synthase inhibitor.

  Nucleosides, nucleotides & nucleic acids 20050101

• A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame.

  Virology journal 20050101

• Immunohistochemical detection of dUTPase in intracranial tumors.

  Pathology, research and practice 20050101

• [Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives].

  Bioorganicheskaia khimiia 20050101

• Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture.

  Journal of biomedicine & biotechnology 20050101

• DNA interstrand cross-links from modified nucleotides: mechanism and application.

  Nucleic acids symposium series (2004) 20050101

• Pyrene-labeled deoxyuridine and deoxyadenosine: fluorescent discriminating phenomena in their duplex and hairpin oligonucleotides.

  Nucleic acids symposium series (2004) 20050101

• RNA template-directed photoligation via 5-carboxyvinyl-2'-deoxyuridine.

  Nucleic acids symposium series (2004) 20050101

• Reactivity of 2'-deoxyuridin-1'-yl radical in various DNA structures.

  Nucleic acids symposium series (2004) 20050101

• SNPs typing by base-discriminating fluorescence DNA probe.

  Nucleic acids symposium series (2004) 20050101

• Mild generation of 5-(2'-deoxyuridinyl)methyl radical from a phenyl selenide precursor.

  Organic letters 20041223

• Induction of gene mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue.

  Mutation research 20041221

• Induction of A:T to G:C transition mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue, in the bone marrow of Muta Mouse.

  Mutation research 20041221

• Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase.

  Biochemistry 20041102

• In vivo evidence for apoptosis, but not inflammation in the hindlimb muscle of neuropathic rats.

  Pain 20041101

• A homogeneous time-resolved fluorescence detection of telomerase activity.

  Analytical biochemistry 20041001

• Calorimetric determination of thermodynamic parameters of 2'-dUMP binding to Leishmania major dUTPase.

  Biochimica et biophysica acta 20041001

• Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.

  Journal of natural products 20041001

• Thymidine phosphorylase deficiency causes MNGIE: an autosomal recessive mitochondrial disorder.

  Nucleosides, nucleotides & nucleic acids 20041001

• Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum.

  Nucleosides, nucleotides & nucleic acids 20041001

• Stabilizing or destabilizing oligodeoxynucleotide duplexes containing single 2'-deoxyuridine residues with 5-alkynyl substituents.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20040820

• Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

  Biochemical pharmacology 20040815

• Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide.

  American journal of physiology. Lung cellular and molecular physiology 20040801

• Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma.

  Gut 20040801

• Endogenous expression of activation-induced cytidine deaminase in cell line WEHI-231.

  Journal of immunology (Baltimore, Md. : 1950) 20040801

• Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes.

  Analytical biochemistry 20040701

• Oxidation of 5-hydroxy-2'-deoxyuridine into isodialuric acid, dialuric acid, and hydantoin products.

  Journal of the American Chemical Society 20040602

• Pyrene-labeled base-discriminating fluorescent DNA probes for homogeneous SNP typing.

  Journal of the American Chemical Society 20040421

• The regulation of somatic hypermutation.

  Current opinion in immunology 20040401

• Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040401

• Effect of GLP-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion.

  Pancreas 20040301

• Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218

• Lysine directed cross-linking of viral DNA-RNA:DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase.

  Biochemistry 20040210

• The first direct evaluation of the two-active site mechanism for chitin synthase.

  The Journal of organic chemistry 20040206

• In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2'-deoxyuridine activated by hypoxic irradiation.

  International journal of radiation oncology, biology, physics 20040201

• Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

  European journal of immunology 20040201

• Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.

  British journal of cancer 20040126

• ND5 is a hot-spot for multiple atypical mitochondrial DNA deletions in mitochondrial neurogastrointestinal encephalomyopathy.

  Human molecular genetics 20040101

• Definitive diagnosis of mitochondrial neurogastrointestinal encephalomyopathy by biochemical assays.

  Clinical chemistry 20040101

• Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a disease of two genomes.

  The neurologist 20040101

• Use of folic acid casei medium reveals trimethoprim susceptibility of Lactobacillus species.

  Letters in applied microbiology 20040101

• Relationship of cell proliferation (Ki-67) to 99mTc-(V)DMSA uptake in breast cancer.

  Breast cancer research : BCR 20040101

• A new approach for the synthesis of novel 5-substituted isodeoxyuridine analogs.

  Nucleosides, nucleotides & nucleic acids 20040101

• Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20040101

• Molecular modeling of the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

  Nucleosides, nucleotides & nucleic acids 20040101

• Tissue-specific spatial organization of genomes.

  Genome biology 20040101

• [Monomers for oligonucleotide synthesis with linkers carrying reactive residues: II. Synthesis of phosphoamidites based of uridine and cytosine and containing a linker with methoxyoxalamide groups in position 2'].

  Bioorganicheskaia khimiia 20040101

• Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells.

  Retrovirology 20040101

• [Antisense oligonucleotides with antitumor activity].

  Magyar onkologia 20040101

• [Potentiation of 5-fluorouracil efficacy. Molecular mechanisms playing a role in the cytotoxic action of 5-fluorouracil and 5-ethyl-2'-deoxyuridine (EUdR) combination].

  Magyar onkologia 20040101

• Immobilization and stabilization of recombinant multimeric uridine and purine nucleoside phosphorylases from Bacillus subtilis.

  Biomacromolecules 20040101

• Reversible DNA photoligation via alpha-5-cyanovinyldeoxyuridine.

  Nucleic acids symposium series (2004) 20040101

• X-ray analyses of DNA duplexes containing 5-(N-aminohexyl)carbamoyl modifications.

  Nucleic acids symposium series (2004) 20040101

• Novel low-molecular-weight hydrogelators based on 2'-deoxyuridine.

  Chemical communications (Cambridge, England) 20031207

• Replication labeling patterns and chromosome territories typical of mammalian nuclei are conserved in the early metazoan Hydra.

  Chromosoma 20031201

• The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.

  Nature medicine 20031101

• Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth.

  Molecular microbiology 20031101

• Independent generation of 5-(2'-deoxycytidinyl)methyl radical and the formation of a novel cross-link lesion between 5-methylcytosine and guanine.

  Journal of the American Chemical Society 20031022

• Regulation of bovine corneal endothelial cell cycle by transforming growth factor-beta.

  Acta ophthalmologica Scandinavica 20031001

• Pharmacokinetics and metabolism of 5-125I-iodo-4'-thio-2'-deoxyuridine in rodents.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031001

• Proliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol.

  Toxicology and applied pharmacology 20031001

• Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations.

  Chemical research in toxicology 20030901

• Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by schiff base-mediated crosslinking.

  Bioorganic & medicinal chemistry letters 20030901

• 5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay.

  The Journal of biological chemistry 20030829

• Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

  British journal of cancer 20030804

• Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.

  Chembiochem : a European journal of chemical biology 20030804

• Identification of a novel human uridine phosphorylase.

  Biochemical and biophysical research communications 20030718

• Modified DNA bearing 5(methoxycarbonylmethyl)-2'-deoxyuridine: preparation by PCR with thermophilic DNA polymerase and postsynthetic derivatization.

  Chembiochem : a European journal of chemical biology 20030707

• Conformational structures and vibrational spectra of isolated pyrimidine nucleosides: Fourier transform infrared matrix isolation study of 2-deoxyuridine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030701

• Photochemical cross-linking of Escherichia coli Fpg protein to DNA duplexes containing phenyl(trifluoromethyl)diazirine groups.

  European journal of biochemistry 20030701

• Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders.

  Clinical chemistry and laboratory medicine 20030701

• Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines.

  British journal of cancer 20030616

• Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency.

  The Journal of clinical investigation 20030615

• DNA deamination mediates innate immunity to retroviral infection.

  Cell 20030613

• Immunomodulation of hepatic ischemic injury via increased Bcl-X(L) and decreased Bcl-X(S).

  The Journal of surgical research 20030601

• Synthesis and enzymatic transformations of 5-halo-6-methoxy-5,6-dihydro derivatives of 5-[1-methoxy-2-halo (or 2,2-dihalo)ethyl]-2'-deoxyuridines as potential herpes simplex virus inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20030601

• Independent generation and study of 5,6-Dihydro-2'-deoxyuridin-6-yl, a member of the major family of reactive intermediates formed in DNA from the effects of gamma-radiolysis.

  The Journal of organic chemistry 20030530

• 2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.

  Journal of the National Cancer Institute 20030507

• Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges.

  Organic & biomolecular chemistry 20030507

• Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues.

  Antiviral chemistry & chemotherapy 20030501

• Oligo-2'-deoxyribonucleotides containing uracil modified at the 5-position with linkers ending with guanidinium groups.

  Journal of the American Chemical Society 20030416

• A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030401

• The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase.

  The Journal of biological chemistry 20030328

• Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiency.

  Biochemical and biophysical research communications 20030328

• Effect of pH and sodium chloride on the strength and selectivity of the interaction of gamma [correction for tau] -cyclodextrin with some antisense nucleosides.

  International journal of pharmaceutics 20030326

• DFT analysis of NMR scalar interactions across the glycosidic bond in DNA.

  Journal of the American Chemical Society 20030326

• Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: 'nitric oxide donor' agents for evaluation as anticancer and antiviral agents.

  Journal of medicinal chemistry 20030313

• A balanced deoxyribonucleoside mixture increased the rate of DNA incorporation of 5-[125I]Iodo-2'-deoxyuridine in glioblastoma cells.

  Cancer biotherapy & radiopharmaceuticals 20030201

• Pathways of accumulation and repair of deoxyuridine residues in DNA of higher and lower organisms.

  Biochemistry. Biokhimiia 20030201

• Evaluation of 5-[1-(2-halo(or nitro)ethoxy-2-iodoethyl)]-2'-deoxyuridines as inhibitors of herpes simplex virus.

  Journal of enzyme inhibition and medicinal chemistry 20030201

• Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies.

  Bioorganic & medicinal chemistry 20030102

• Microwave-assisted synthesis of O'-adamantylated uracil-derived nucleosides.

  Nucleosides, nucleotides & nucleic acids 20030101

• Synthesis of a novel aldehyde: 4-O-methyl-5-formylmethyl-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20030101

• The effects of middle cerebral artery occlusion on central nervous system apoptotic events in normal and diabetic rats.

  International journal of experimental diabesity research 20030101

• [Effects of childhood nutrition on adult health].

  Allergologia et immunopathologia 20030101

• [Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives].

  Bioorganicheskaia khimiia 20030101

• The NMR studies of substituent effects on the N-H...N hydrogen bond in duplex DNA using 2'-deoxynebularine and 15N labeled 5-substituted-2'-deoxyuridine base pairs.

  Nucleic acids research. Supplement (2001) 20030101

• Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

  Nucleosides, nucleotides & nucleic acids 20030101

• New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides.

  Nucleosides, nucleotides & nucleic acids 20030101

• Synthesis of modified DNAs bearing two different fluorescent probes and its application to fluorescence resonance energy transfer.

  Nucleosides, nucleotides & nucleic acids 20030101

• Hydrolytic reactions of diribonucleoside 3',5'-(3'-N-phosphoramidates): kinetics and mechanisms for the P-O and P-N bond cleavage of 3'-amino-3'-deoxyuridylyl-3',5'-uridine.

  Journal of the American Chemical Society 20021204

• DNA duplexes containing photoactive derivatives of 2'-deoxyuridine as photocrosslinking probes for EcoRII DNA methyltransferase-substrate interaction.

  Journal of biomolecular structure & dynamics 20021201

• Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE).

  Journal of inherited metabolic disease 20021101

• Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3'-deoxycytidine.

  Antiviral chemistry & chemotherapy 20021101

• 5-amino-2'-deoxyuridine, a novel thymidine analogue for high-resolution footprinting of protein-DNA complexes.

  Organic letters 20021031

• Radiolabelled thymidines and deoxyuridines for measuring cellular proliferation in tumours--an update.

  Nuclear medicine communications 20021001

• Synthesis of 5-(pyridinyl and pyridiniumyl)-2'-deoxyuridine nucleosides: reversible electron traps for DNA.

  Nucleosides, nucleotides & nucleic acids 20021001

• Rationale of 5-(125)I-iodo-4'-thio-2'-deoxyuridine as a potential iodinated proliferation marker.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020901

• Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

  FEBS letters 20020828

• Repair of flexor tendon defects of rabbit with tissue engineering method.

  Chinese journal of traumatology = Zhonghua chuang shang za zhi 20020801

• Formation of 2'-deoxyuridine hydrates upon exposure of nucleosides to gamma radiation and UVC-irradiation of isolated and cellular DNA.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20020801

• Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending.

  Journal of the American Chemical Society 20020724

• Fluorescent 1,10-phenanthroline-containing oligonucleotides distinguish between perfect and mismatched base pairing.

  Organic letters 20020711

• Changes in nuclear matrix proteins during the senescence-like phenomenon induced by 5-chlorodeoxyuridine in HeLa cells.

  Experimental gerontology 20020701

• Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.

  Biochemistry 20020611

• Chemical synthesis and biochemical properties of oligonucleotides that contain the (5'S,5S,6S)-5',6-cyclo-5-hydroxy-5,6-dihydro-2'-deoxyuridine DNA lesion.

  Chembiochem : a European journal of chemical biology 20020603

• Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis.

  The Journal of biological chemistry 20020503

• Unlabelled iododeoxyuridine increases the rate of uptake of [125I]iododeoxyuridine in human xenografted glioblastomas.

  European journal of nuclear medicine and molecular imaging 20020401

• Water mediated Dickerson-Drew-type crystal of DNA dodecamer containing 2'-deoxy-5-formyluridine.

  Biophysical chemistry 20020328

• Binding properties of oligonucleotides containing a modified 2'-deoxyuridine with a thymine ended linker to pair with 2'-deoxyadenosine.

  Bioorganic & medicinal chemistry letters 20020325

• Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: the protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5' side.

  Journal of the American Chemical Society 20020313

• One-pot two-step enzymatic coupling of pyrimidine bases to 2-deoxy-D-ribose-5-phosphate. A new strategy in the synthesis of stable isotope labeled deoxynucleosides.

  The Journal of organic chemistry 20020308

• The Escherichia coli tRNA-guanine transglycosylase can recognize and modify DNA.

  The Journal of biological chemistry 20020301

• Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution.

  Biochemistry 20020226

• Synthesis of dicobalt hexacarbonyl 5-p-tolylethynyl-2'-deoxyuridine.

  Chemical communications (Cambridge, England) 20020221

• 5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity.

  Bioorganic & medicinal chemistry letters 20020211

• Prognostic value of thymidine phosphorylase expression in breast carcinoma.

  International journal of cancer 20020201

• Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020101

• [Chromosomal abnormalities in lymphocytes from a patient with Werner's syndrome in intact culture and after treatment with halogenated analogs of thymidine].

  Tsitologiia 20020101

• [4'-Thio-5-ethyl-2'-deoxyuridine 5'-phosphonates: synthesis and antiviral activity].

  Bioorganicheskaia khimiia 20020101

• Prolactin signaling and Stat5: going their own separate ways?

  Breast cancer research : BCR 20020101

• Synthesis of 5-(2,2'-bipyridinyl and 2,2'-bipyridinediiumyl)-2'-deoxyuridine nucleosides: precursors to metallo-DNA conjugates.

  Nucleosides, nucleotides & nucleic acids 20020101

• Conformation dependent DNA photoligation via sensitizer tethered 5-carboxyvinyluracil.

  Nucleic acids research. Supplement (2001) 20020101

• Glycine rich P-loop motif in deoxyuridine pyrophosphatase.

  Current protein & peptide science 20011201

• Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.

  Nature genetics 20011101

• C5-(1-propynyl)-2'-deoxy-pyrimidines enhance mismatch penalties of DNA:RNA duplex formation.

  Biochemistry 20011023

• Uracil-DNA glycosylase acts by substrate autocatalysis.

  Nature 20011018

• Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.

  Journal of medicinal chemistry 20011011

• Incorporation of 2'-deoxy-5-(trifluoromethyl)uridine and 5-cyano-2'-deoxyuridine into DNA.

  Bioorganic & medicinal chemistry letters 20010917

• Synthesis of certain 2'-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5'; evaluation as potential dUTP analogues.

  Nucleosides, nucleotides & nucleic acids 20010901

• Synthesis and evaluation of a C-glycosyl nucleoside as an inhibitor of chitin synthase.

  Carbohydrate research 20010830

• Reduced thymocyte proliferation but not increased apoptosis as a possible cause of thymus atrophy in iron-deficient mice.

  The British journal of nutrition 20010801

• Reconstructing the substrate for uracil DNA glycosylase: tracking the transmission of binding energy in catalysis.

  Biochemistry 20010626

• Cell proliferation, apoptosis, NF-kappaB expression, enzyme, protein, and weight changes in livers of burned rats.

  American journal of physiology. Gastrointestinal and liver physiology 20010601

• Interaction of a group II intron ribonucleoprotein endonuclease with its DNA target site investigated by DNA footprinting and modification interference.

  Journal of molecular biology 20010601

• Crystallization and preliminary crystallographic analysis of deoxyuridine 5'-triphosphate nucleotidohydrolase from Bacillus subtilis.

  Acta crystallographica. Section D, Biological crystallography 20010601

• 1H NMR conformational study of a variety of alpha-anomers of C5-substituted 2'-deoxyuridines: comparison to their antiherpetic beta counterparts.

  Biochemical and biophysical research communications 20010525

• Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.

  Mutation research 20010509

• Palladium-mediated C5 substitution of pyrimidine nucleosides.

  Current protocols in nucleic acid chemistry 20010501

• A 2'-acylamido cap that increases the stability of oligonucleotide duplexes.

  Organic letters 20010405

• Cytosolic high K(m) 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism.

  The Journal of biological chemistry 20010302

• Active intestinal absorption of nucleosides by Na+-dependent transport across the brush border membrane in cows.

  Journal of dairy science 20010301

• Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.

  Bioorganic & medicinal chemistry 20010301

• The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue.

  Biochemistry 20010220

• 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism.

  Toxicology letters 20010203

• Crystallization and preliminary X-ray analysis of a DNA dodecamer containing 2'-deoxy-5-formyluridine; what is the role of magnesium cation in crystallization of Dickerson-type DNA dodecamers?

  Acta crystallographica. Section D, Biological crystallography 20010201

• G-protein expression and intimal hyperplasia after arterial injury: a role for Galpha(i) proteins.

  Journal of vascular surgery 20010201

• Synthesis of 2'-modified oligodeoxynucleotides via on-column conjugation.

  The Journal of organic chemistry 20010126

• A phase I study of nolatrexed dihydrochloride in children with advanced cancer. A United Kingdom Children's Cancer Study Group Investigation.

  British journal of cancer 20010101

• Synthesis of the first ferrocene-labeled dideoxynucleotide and its use for 3'-redox end-labeling of 5'-modified single-stranded oligonucleotides.

  Bioconjugate chemistry 20010101

• Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20010101

• 5-(phenylthiomethyl)-2'-deoxyuridine as an efficient photoreactive precursor to generate single and multiple lesions within DNA fragments.

  Nucleosides, nucleotides & nucleic acids 20010101

• Synthesis of 5-methylamino-2'-deoxyuridine derivatives.

  Nucleosides, nucleotides & nucleic acids 20010101

• Dynamic SIMS ion microscopy imaging of intracellular boron accumulation from carboranyl nucleosides in glioma cells.

  Anticancer research 20010101

• Synthesis of 5-substituted [N3-15N]-pyrimidine nucleosides: Developing model systems for NMR studies of substituent effects on the N-H...N hydrogen bond in duplex DNA.

  Nucleic acids research. Supplement (2001) 20010101

• Investigation of antisense DNA having C-5 polyamine substituted 2'-deoxyuridine derivative.

  Nucleic acids research. Supplement (2001) 20010101

• Evidence for a Schiff base formation of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

  Nucleic acids research. Supplement (2001) 20010101

• Template directed DNA photoligation via substituted 2'-deoxyuridine.

  Nucleic acids research. Supplement (2001) 20010101

• X-ray analyses of DNA dodecamers containing 2'-deoxy-5-formyluridine.

  Nucleic acids research. Supplement (2001) 20010101

• Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes.

  The Biochemical journal 20001015

• Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.

  Journal of medicinal chemistry 19990826

• Novel spironucleosides: 1',3'-thiazolidine-2'-spiro-3'-3'-deoxyuridine derivatives.

  Nucleosides & nucleotides 19980601

• Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.

  Nucleosides & nucleotides 19980101

• Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

  Journal of medicinal chemistry 19961122

• Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines.

  Antiviral research 19960501

• Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.

  Antiviral research 19940801

• Synthesis of 5-[1-hydroxy (or methoxy)-2,2-dihaloethyl]-2'- deoxyuridines with antiviral and cytotoxic activity.

  Antiviral research 19940801

• New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

  The Journal of biological chemistry 19940722

• Synthesis, biotransformation, pharmacokinetics, and antiviral properties of 5-ethyl-5-halo-6-methoxy-5,6-dihydro-2'-deoxyuridine diastereomers.

  Biochemical pharmacology 19940429

• Cellular pharmacology and biological activity of 5-carboranyl-2'-deoxyuridine.

  International journal of radiation oncology, biology, physics 19940330

• Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.

  Journal of medicinal chemistry 19930820

• Metabolism and mode of selective inhibition of human immunodeficiency virus replication by 3'-azido-2',3'-dideoxy-5-iodouridine and 3'-azido-2',3'-dideoxy-5-bromouridine.

  Biochemical pharmacology 19930107

• Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine.

  Antiviral research 19910901

• 5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.

  Journal of medicinal chemistry 19910801

• Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.

  Journal of medicinal chemistry 19910801

• Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.

  Journal of medicinal chemistry 19910601

• Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine.

  Journal of medicinal chemistry 19910401

• Mechanism of action of 5-(2-chloroethyl)-2'-deoxyuridine, a selective inhibitor of herpes simplex virus replication.

  Molecular pharmacology 19900501

• Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors.

  Antiviral research 19900301

• Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.

  Journal of medicinal chemistry 19900201

• Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.

  Journal of medicinal chemistry 19890801

• Synthesis and antiviral activity of several 2,5'-anhydro analogues of 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-azido-2',3'-dideoxy-5-halouridines, and 3'-deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus.

  Journal of medicinal chemistry 19890801

• Synthesis of 5-[1-hydroxy(or methoxy)-2-bromo(or chloro)ethyl]-2'-deoxyuridines and related halohydrin analogues with antiviral and cytotoxic activity.

  Journal of medicinal chemistry 19890501

• Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.

  Proceedings of the National Academy of Sciences of the United States of America 19890201

• Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.

  Journal of medicinal chemistry 19880901

• Specific phosphorylation of 5-ethyl-2'-deoxyuridine by herpes simplex virus-infected cells and incorporation into viral DNA.

  The Journal of biological chemistry 19871105

• 2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.

  Journal of medicinal chemistry 19870701

• In vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil.

  Antiviral research 19870601

• Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.

  Journal of medicinal chemistry 19860501

• Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.

  Journal of medicinal chemistry 19860201

• Synthesis and antiviral activity of the carbocyclic analogues of 5-ethyl-2'-deoxyuridine and of 5-ethynyl-2'-deoxyuridine.

  Journal of medicinal chemistry 19860101

• 5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.

  Journal of medicinal chemistry 19851101

• Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus.

  Antimicrobial agents and chemotherapy 19850801

• Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

  Journal of medicinal chemistry 19850501

• Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with trifluorothymidine, phosphonoformate and acycloguanosine against herpes simplex viruses.

  Antiviral research 19850201

• 5-Ethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation demonstrated with human leukemic cells and PHA-stimulated lymphocytes in vitro.

  Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 19850101

• Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.

  Journal of medicinal chemistry 19840301

• Comparison of the antiviral effects of 5-methoxymethyldeoxyuridine-5'-monophosphate with adenine arabinoside-5'-monophosphate.

  Antiviral research 19830901

• Structural requirements of olefinic 5-substituted deoxyuridines for antiherpes activity.

  Journal of medicinal chemistry 19830901

• Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2.

  Antimicrobial agents and chemotherapy 19830501

• Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.

  Journal of medicinal chemistry 19830201

• Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.

  Journal of medicinal chemistry 19821101

• Antiherpes activity of [E]-5-(1-propenyl)-2'-deoxyuridine and 5-(1-propenyl)-1-beta-D-arabinofuranosyluracil.

  Antiviral research 19811101

• Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.

  Journal of medicinal chemistry 19810401

• Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2'-deoxyuridine and their 5'-phosphates.

  Biochemical pharmacology 19810301

• Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy.

  Antimicrobial agents and chemotherapy 19801201

• Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2.

  Antimicrobial agents and chemotherapy 19800401

• Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.

  Journal of medicinal chemistry 19800301

• Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines.

  Biochemical pharmacology 19791115

• Effect of treatment with 5-ethyl-2'-deoxyuridine on herpes simplex virus encephalitis in normal and immunosuppressed mice.

  Antimicrobial agents and chemotherapy 19781101

• 5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.

  Antimicrobial agents and chemotherapy 19780301

• 5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.

  Journal of medicinal chemistry 19780201

• Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.

  Journal of medicinal chemistry 19770701

• Antiviral action and cellular toxicity of four thymidine analogues: 5-ethyl-,5-vinyl-, 5-propyl-, and 5-allyl-2'- deoxyuridine.

  Antimicrobial agents and chemotherapy 19760701

• Effect of cytosine, arabinoside, iododeoxyuridine, ethyldeoxyuridine, thiocyanatodeoxyuridine, and ribavirin on tail lesion formation in mice infected with vaccinia virus.

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19760301

• Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice.

  Cancer research 19750601

• Mechanism of triamterene-induced megaloblastosis.

  Annals of internal medicine 19700901

• Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.

  The New England journal of medicine 19690612

• The antiviral activity of 9-beta-D-arabinofuranosyladenine (ARA-A).

  Chemotherapia 19680101

• Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent.

  Journal of medicinal chemistry 19660501