951-78-0 | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$15.00	$10.00
1g	98%	in stock	$19.00	$13.00
5g	98%	in stock	$20.00	$14.00
25g	98%	in stock	$61.00	$43.00
500g	98%	in stock	$1,196.00	$837.00

Description

• Catalog Number: AC70869
• Chemical Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• CAS Number: 951-78-0
• Molecular Formula: C9H12N2O5
• Molecular Weight: 228.202
• MDL Number: MFCD00006527
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O

Computed Properties

• Complexity: 343
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -1.6

Literature

• The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides.

  Chemico-biological interactions 20151005

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin stimulates proliferation of HAPI microglia by affecting the Akt/GSK-3β/cyclin D1 signaling pathway.

  Toxicology letters 20140130

• Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20121024

• Synthesis and photophysical study of 2'-deoxyuridines labeled with fluorene derivatives.

  Molecules (Basel, Switzerland) 20121015

• Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-β1.

  The Journal of nutritional biochemistry 20121001

• Multicolor flow cytometry analysis of the proliferations of T-lymphocyte subsets in vitro by EdU incorporation.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20121001

• Design and synthesis of 3-carbamoylbenzoic acid derivatives as inhibitors of human apurinic/apyrimidinic endonuclease 1 (APE1).

  ChemMedChem 20121001

• Drastic enhancement of excess electron-transfer efficiency through DNA by inserting consecutive 5-phenylethynyl-2'-deoxyuridines as a modulator.

  Chemical communications (Cambridge, England) 20120928

• Bone marrow cells stained by azide-conjugated Alexa fluors in the absence of an alkyne label.

  Stem cells and development 20120901

• Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120808

• Apoptosis in Buruli ulcer: a clinicopathological study of 45 cases.

  Histopathology 20120801

• Insulin-like growth factor I receptor involvement in proliferation of NOR-P1 cells in serum-free media.

  Journal of cellular biochemistry 20120801

• A method for evaluating the host range of bacteriophages using phages fluorescently labeled with 5-ethynyl-2'-deoxyuridine (EdU).

  Applied microbiology and biotechnology 20120801

• The biochemistry of activation-induced deaminase and its physiological functions.

  Seminars in immunology 20120801

• Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120801

• Transporting excess electrons along potential energy gradients provided by 2'-deoxyuridine derivatives in DNA.

  Angewandte Chemie (International ed. in English) 20120723

• Synthesis and study of cyclic pronucleotides of 5-fluoro-2'-deoxyuridine.

  Bioorganic & medicinal chemistry letters 20120715

• Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

  The Biochemical journal 20120701

• The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration.

  Endocrinology 20120701

• Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria.

  Journal of neurochemistry 20120701

• Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.

  European journal of medicinal chemistry 20120701

• Differentiating neural crest stem cells induce proliferation of cultured rodent islet beta cells.

  Diabetologia 20120701

• Human endonuclease V as a repair enzyme for DNA deamination.

  Mutation research 20120701

• [Protective effect of endothelin-1 in goldblatt 'one-kidney, one-clip' hypertension].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20120701

• Enhancement of fluorescence quenching and exciplex formation in DNA major groove by double incorporation of modified fluorescent deoxyuridines.

  Bioorganic & medicinal chemistry letters 20120615

• Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement.

  PLoS genetics 20120601

• N-h and N-C bond activation of pyrimidinic nucleobases and nucleosides promoted by an osmium polyhydride.

  Inorganic chemistry 20120521

• Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding.

  The Journal of biological chemistry 20120518

• Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice.

  Hepatology (Baltimore, Md.) 20120501

• Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase.

  Molecular therapy : the journal of the American Society of Gene Therapy 20120501

• CoQ(10) deficiencies and MNGIE: two treatable mitochondrial disorders.

  Biochimica et biophysica acta 20120501

• Recognition of damaged DNA: structure and dynamic markers.

  Medicinal research reviews 20120501

• Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives.

  Bioorganic & medicinal chemistry letters 20120415

• Differences in the enzymatic efficiency of human and bony fish AID are mediated by a single residue in the C terminus modulating single-stranded DNA binding.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120401

• A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.

  Nucleosides, nucleotides & nucleic acids 20120401

• Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation.

  Oncogene 20120308

• Label retaining and stem cell marker expression in the developing rat urinary bladder.

  Urology 20120301

• Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA.

  Nature protocols 20120301

• Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.

  Chemistry & biodiversity 20120301

• Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv.

  Journal of molecular modeling 20120201

• 5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells.

  Apoptosis : an international journal on programmed cell death 20120201

• Identification of active and quiescent adipose vascular stromal cells.

  Cytotherapy 20120201

• The giant danio (D. aequipinnatus) as a model of cardiac remodeling and regeneration.

  Anatomical record (Hoboken, N.J. : 2007) 20120201

• Super-resolution fluorescence imaging of chromosomal DNA.

  Journal of structural biology 20120201

• Construction and completion of flux balance models from pathway databases.

  Bioinformatics (Oxford, England) 20120201

• A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.

  Nature neuroscience 20120115

• p38 mitogen-activated protein kinase is a key regulator of 5-phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine-induced apoptosis in human HL-60 cells.

  Biochemical and biophysical research communications 20120106

• The opiate analgesic buprenorphine decreases proliferation of adult hippocampal neuroblasts and increases survival of their progeny.

  Neuroscience 20120103

• The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response.

  Nature neuroscience 20120101

• Efficient microwave-assisted synthesis, antibacterial activity and high fluorescence of 5 benzimidazolyl-2'-deoxyuridines.

  Bioorganic & medicinal chemistry 20120101

• Assessment of thymidine phosphorylase function: measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity.

  Methods in molecular biology (Clifton, N.J.) 20120101

• The genome and proteome of a Campylobacter coli bacteriophage vB_CcoM-IBB_35 reveal unusual features.

  Virology journal 20120101

• ArgR of Streptomyces coelicolor is a versatile regulator.

  PloS one 20120101

• The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques.

  PloS one 20120101

• Genomic, proteomic and physiological characterization of a T5-like bacteriophage for control of Shiga toxin-producing Escherichia coli O157:H7.

  PloS one 20120101

• Pharmacodynamic modelling of biomarker data in oncology.

  ISRN pharmacology 20120101

• Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.

  Retrovirology 20120101

• Comparative (meta)genomic analysis and ecological profiling of human gut-specific bacteriophage φB124-14.

  PloS one 20120101

• Overexpression of angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts.

  PloS one 20120101

• The cyclobutane dimers of 2'-deoxyuridine, 2'-deoxycytidine, 5-methyl-2'-deoxycytidine and 5-bromo-2'-deoxyuridine.

  Photochemistry and photobiology 20120101

• Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy.

  PloS one 20120101

• The Role of Elongin BC-Containing Ubiquitin Ligases.

  Frontiers in oncology 20120101

• The dUTPase enzyme is essential in Mycobacterium smegmatis.

  PloS one 20120101

• SIV replication in human cells.

  Frontiers in microbiology 20120101

• Stereoselective synthesis of uridine-derived nucleosyl amino acids.

  The Journal of organic chemistry 20111216

• Measurement of apoptosis in cytological specimens by flow cytometry: comparison of Annexin V, caspase cleavage and dUTP incorporation assays.

  Cytopathology : official journal of the British Society for Clinical Cytology 20111201

• Dicer is required for the maintenance of notch signaling and gliogenic competence during mouse retinal development.

  Developmental neurobiology 20111201

• Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using 'click chemistry'.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20111101

• Anemia in elderly Koreans.

  Yonsei medical journal 20111101

• Mitochondrial neurogastrointestinal encephalopathy in an Indian family with possible manifesting carriers of heterozygous TYMP mutation.

  Journal of the neurological sciences 20111015

• Draft genome sequence of the coccolithovirus EhV-84.

  Standards in genomic sciences 20111015

• Isoflurane decreases self-renewal capacity of rat cultured neural stem cells.

  Anesthesiology 20111001

• 5-Ethynyl-2'-deoxycytidine as a new agent for DNA labeling: detection of proliferating cells.

  Analytical biochemistry 20111001

• Auger electron emitter against multiple myeloma--targeted endo-radio-therapy with 125I-labeled thymidine analogue 5-iodo-4'-thio-2'-deoxyuridine.

  Nuclear medicine and biology 20111001

• Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20110915

• Thymidine analogues for tracking DNA synthesis.

  Molecules (Basel, Switzerland) 20110915

• Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics.

  Journal of the American Chemical Society 20110914

• Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20110901

• Multisensing emissive pyrimidine.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20110822

• Proliferation, migration and differentiation in juvenile and adult Xenopus laevis brains.

  Brain research 20110808

• Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove.

  The Journal of organic chemistry 20110805

• Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo.

  The pharmacogenomics journal 20110801

• Role of the haem oxygenase/carbon monoxide pathway in Clostridium difficile toxin A-induced enteritis in mice.

  Journal of medical microbiology 20110801

• Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIE.

  Gene therapy 20110801

• Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase.

  European journal of medicinal chemistry 20110801

• Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication.

  PLoS computational biology 20110801

• Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720

• DeltaNp63 regulates stem cell dynamics in the mammalian olfactory epithelium.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110615

• ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof.

  Investigational new drugs 20110601

• Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.

  Investigational new drugs 20110601

• Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.

  PLoS genetics 20110601

• The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine.

  The Journal of biological chemistry 20110506

• Identification and characterization of 2'-deoxyuridine from the supernatant of conidial suspensions of rice blast fungus as an infection-promoting factor in rice plants.

  Molecular plant-microbe interactions : MPMI 20110501

• Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products.

  Archives of biochemistry and biophysics 20110501

• Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy.

  Journal of the American Chemical Society 20110427

• A direct comparison of azide and nitrile vibrational probes.

  Physical chemistry chemical physics : PCCP 20110407

• A phase I study of pemetrexed in patients with relapsed or refractory acute leukemia.

  Investigational new drugs 20110401

• Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

  Fundamental & clinical pharmacology 20110401

• Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo.

  Diabetes, obesity & metabolism 20110401

• Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase.

  The Journal of biological chemistry 20110401

• β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

  Bioorganic & medicinal chemistry 20110401

• Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method.

  Analytical chemistry 20110315

• Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU.

  ChemMedChem 20110307

• Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

  PLoS genetics 20110301

• Potent radiosensitizing agents: 5-methylselenyl- and 5-phenylselenyl-methyl-2'-deoxyuridine.

  Bioorganic & medicinal chemistry letters 20110215

• Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups.

  Bioorganic & medicinal chemistry letters 20110215

• 2D IR photon echo of azido-probes for biomolecular dynamics.

  Physical chemistry chemical physics : PCCP 20110214

• Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase.

  ChemMedChem 20110207

• Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells.

  Stem cells and development 20110201

• Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.

  Journal of inherited metabolic disease 20110201

• Use of base modifications in primers and amplicons to improve nucleic acids detection in the real-time snake polymerase chain reaction.

  Assay and drug development technologies 20110201

• Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.

  European journal of medicinal chemistry 20110201

• The effects of the 4-(4-Methylpiperazine)phenyl group on nucleosides and oligonucleotides: cellular delivery, detection, and stability.

  Chemistry, an Asian journal 20110201

• Chemical synthesis of site-specifically 2'-azido-modified RNA and potential applications for bioconjugation and RNA interference.

  Chembiochem : a European journal of chemical biology 20110103

• Characterization and functionality of proliferative human Sertoli cells.

  Cell transplantation 20110101

• Dual-pulse labeling using 5-ethynyl-2'-deoxyuridine (EdU) and 5-bromo-2'-deoxyuridine (BrdU) in flow cytometry.

  Current protocols in cytometry 20110101

• Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors.

  Silence 20110101

• Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle.

  PloS one 20110101

• Homologous recombination is stimulated by a decrease in dUTPase in Arabidopsis.

  PloS one 20110101

• UMP/CMPK is not the critical enzyme in the metabolism of pyrimidine ribonucleotide and activation of deoxycytidine analogs in human RKO cells.

  PloS one 20110101

• Deoxyuridines from the marine sponge associated actinomycete Streptomyces microflavus.

  Marine drugs 20110101

• Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.

  PloS one 20110101

• Site-specific DNA labeling by Staudinger ligation.

  Methods in molecular biology (Clifton, N.J.) 20110101

• Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome-wide analysis.

  Cell & bioscience 20110101

• Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi?

  Case reports in oncology 20110101

• Some aspects of purinergic signaling in the ventricular system of porcine brain.

  Acta veterinaria Scandinavica 20110101

• Characterization of family IV UDG from Aeropyrum pernix and its application in hot-start PCR by family B DNA polymerase.

  PloS one 20110101

• The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug trimethoprim.

  BMC genomics 20110101

• Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.

  PloS one 20110101

• Mthfs is an Essential Gene in Mice and a Component of the Purinosome.

  Frontiers in genetics 20110101

• Murine leukemia viruses: objects and organisms.

  Advances in virology 20110101

• Antibody and splenocyte proliferation response to whole inactivated Streptococcus pneumoniae serotype 1, 3 and 6B in mice.

  Roumanian archives of microbiology and immunology 20110101

• (15)N NMR studies of a nitrile-modified nucleoside.

  The journal of physical chemistry. B 20101230

• Site-directed spin-labeling of DNA by the azide-alkyne 'click' reaction: nanometer distance measurements on 7-deaza-2'-deoxyadenosine and 2'-deoxyuridine nitroxide conjugates spatially separated or linked to a 'dA-dT' base pair.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20101227

• Chemoenzymatic syntheses and anti-HIV-1 activity of glucose-nucleoside conjugates as prodrugs.

  Bioconjugate chemistry 20101215

• DeltaA/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

• Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus.

  Bioorganic & medicinal chemistry letters 20101115

• Selective detection of 5-formyl-2'-deoxyuridine, an oxidative lesion of thymidine, in DNA by a fluorogenic reagent.

  Angewandte Chemie (International ed. in English) 20101102

• Molecular mechanism of the DNA sequence selectivity of 5-halo-2'-deoxyuridines as potential radiosensitizers.

  Journal of the American Chemical Society 20101027

• Two nucleoside transporters in Lactococcus lactis with different substrate specificities.

  Microbiology (Reading, England) 20101001

• Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines.

  Bioorganic & medicinal chemistry letters 20101001

• Studying bacterial transcriptomes using RNA-seq.

  Current opinion in microbiology 20101001

• [Molecular combing in studies of the genome organization and DNA replication].

  Genetika 20101001

• Pathogenesis and treatment of mitochondrial myopathies: recent advances.

  Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20101001

• In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1.

  Biochemistry 20100928

• Introduction of guanidinium-modified deoxyuridine into the substrate binding regions of DNAzyme 10-23 to enhance target affinity: implications for DNAzyme design.

  Bioorganic & medicinal chemistry letters 20100901

• Folic Acid supplementation stimulates notch signaling and cell proliferation in embryonic neural stem cells.

  Journal of clinical biochemistry and nutrition 20100901

• Dynamic proliferation assessment in flow cytometry.

  Current protocols in cell biology 20100901

• Genomic and epigenomic instability, fragile sites, schizophrenia and autism.

  Current genomics 20100901

• Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses.

  Viruses 20100901

• TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100801

• Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.

  Clinical biochemistry 20100801

• Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation.

  Birth defects research. Part A, Clinical and molecular teratology 20100801

• Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer.

  Oncology reports 20100801

• Solvent-free synthesis of pyrimidine nucleoside-aminophosphonate hybrids and their biological activity evaluation.

  Nucleosides, nucleotides & nucleic acids 20100801

• Functional and structural impact of target uridine substitutions on the H/ACA ribonucleoprotein particle pseudouridine synthase.

  Biochemistry 20100727

• Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).

  Chemical communications (Cambridge, England) 20100721

• Effect of clozapine on neutrophil kinetics in rabbits.

  Chemical research in toxicology 20100719

• High-performance quantification of mature microRNAs by real-time RT-PCR using deoxyuridine-incorporated oligonucleotides and hemi-nested primers.

  RNA (New York, N.Y.) 20100701

• Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2'-deoxyuridines.

  Bioorganic & medicinal chemistry 20100701

• Highly efficient and facile synthesis of 5-azido-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20100701

• Fluorogenic 'click' reaction for labeling and detection of DNA in proliferating cells.

  BioTechniques 20100701

• EdU (5-ethynyl-2'-deoxyuridine) labeling of Drosophila mitotic neuroblasts.

  Cold Spring Harbor protocols 20100701

• A sensitive multispectroscopic probe for nucleic acids.

  The journal of physical chemistry. B 20100617

• New roles for cyclin E in megakaryocytic polyploidization.

  The Journal of biological chemistry 20100611

• Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601

• Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism.

  European journal of clinical pharmacology 20100601

• The exceptional properties of 9-methyl-beta-carboline: stimulation, protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects.

  Journal of neurochemistry 20100601

• Pasteurella multocida thymidine kinase 1 efficiently activates pyrimidine nucleoside analogs.

  Nucleosides, nucleotides & nucleic acids 20100601

• Constraint-based model of Shewanella oneidensis MR-1 metabolism: a tool for data analysis and hypothesis generation.

  PLoS computational biology 20100601

• GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2.

  Cerebral cortex (New York, N.Y. : 1991) 20100501

• Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high-throughput screening.

  BioTechniques 20100501

• Polymerase incorporation and miscoding properties of 5-chlorouracil.

  Chemical research in toxicology 20100419

• Computational (DFT and TD DFT) study of the electron structure of the tautomers/conformers of uridine and deoxyuridine and the processes of intramolecular proton transfers.

  Journal of molecular modeling 20100401

• Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system.

  Brain research 20100310

• Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition.

  Mutation research 20100301

• Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia.

  American journal of physiology. Renal physiology 20100301

• Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.

  Journal of neurochemistry 20100301

• Early hepatic insulin resistance in mice: a metabolomics analysis.

  Molecular endocrinology (Baltimore, Md.) 20100301

• An evolutionary analysis of lateral gene transfer in thymidylate synthase enzymes.

  Systematic biology 20100301

• DNA damage and interstrand cross-link formation upon irradiation of aryl iodide C-nucleotide analogues.

  The Journal of organic chemistry 20100205

• Mitochondrial DNA (mtDNA) biogenesis: visualization and duel incorporation of BrdU and EdU into newly synthesized mtDNA in vitro.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20100201

• Chelation-controlled regioselective alkylation of pyrimidine 2'-deoxynucleosides.

  Carbohydrate research 20100126

• Nucleotide excision repair of a DNA interstrand cross-link produces single- and double-strand breaks.

  Biochemistry 20100112

• Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).

  Current drug targets 20100101

• Antitumor effect of docetaxel-loaded lipid microbubbles combined with ultrasound-targeted microbubble activation on VX2 rabbit liver tumors.

  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20100101

• Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis.

  Arthritis research & therapy 20100101

• Bioimaging of nucleolin aptamer-containing 5-(N-benzylcarboxyamide)-2'-deoxyuridine more capable of specific binding to targets in cancer cells.

  Journal of biomedicine & biotechnology 20100101

• Plasmodium falciparum proteome changes in response to doxycycline treatment.

  Malaria journal 20100101

• Cobalamin deficiency, hyperhomocysteinemia, and dementia.

  Neuropsychiatric disease and treatment 20100101

• UCE: A uracil excision (USER)-based toolbox for transformation of cereals.

  Plant methods 20100101

• Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines.

  Molecular vision 20100101

• iTRAQ quantitative analysis of multidrug resistance mechanisms in human gastric cancer cells.

  Journal of biomedicine & biotechnology 20100101

• The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination.

  PloS one 20100101

• Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models.

  Molecular systems biology 20100101

• Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: a dual birthdating analysis.

  PloS one 20100101

• Interferon-alpha induces high expression of APOBEC3G and STAT-1 in vitro and in vivo.

  International journal of molecular sciences 20100101

• DNA suspension arrays: silencing discrete artifacts for high-sensitivity applications.

  PloS one 20100101

• Evolution of the Kdo2-lipid A biosynthesis in bacteria.

  BMC evolutionary biology 20100101

• Visualization of mitochondrial DNA replication in individual cells by EdU signal amplification.

  Journal of visualized experiments : JoVE 20100101

• Emergency surgery in chronic intestinal pseudo-obstruction due to mitochondrial neurogastrointestinal encephalomyopathy: case reports.

  International archives of medicine 20100101

• Phylogenetic and phyletic studies of informational genes in genomes highlight existence of a 4 domain of life including giant viruses.

  PloS one 20100101

• A molecular inversion probe assay for detecting alternative splicing.

  BMC genomics 20100101

• Ultrasound-targeted microbubble destruction mediated herpes simplex virus-thymidine kinase gene treats hepatoma in mice.

  Journal of experimental & clinical cancer research : CR 20100101

• Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue.

  Journal of visualized experiments : JoVE 20100101

• Cancer chemotherapy: targeting folic acid synthesis.

  Cancer management and research 20100101

• Current and emerging treatment strategies for the treatment of actinic keratosis.

  Clinical, cosmetic and investigational dermatology 20100101

• Impact of sugar pucker on base pair and mispair stability.

  Biochemistry 20091222

• The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.

  Journal of the American Chemical Society 20091209

• Hematoporphyrin monomethyl ether enhances the killing action of ultrasound on osteosarcoma in vivo.

  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20091201

• 2'-Deoxy-5-propynyluridine: a nucleoside with two conformations in the asymmetric unit.

  Acta crystallographica. Section C, Crystal structure communications 20091201

• EdU incorporation is an alternative non-radioactive assay to [(3)H]thymidine uptake for in vitro measurement of mice T-cell proliferations.

  Journal of immunological methods 20091031

• Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

  Journal of the American Chemical Society 20091014

• Click-iT assay with improved DNA distribution histograms.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20091001

• Crystallization and crystal-packing studies of Chlorella virus deoxyuridine triphosphatase.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20091001

• Hydroxyl-functionalized DNA: an efficient orthogonal protecting strategy and duplex stability.

  Nucleosides, nucleotides & nucleic acids 20091001

• Synthesis and enzymatic incorporation of modified deoxyuridine triphosphates.

  Organic & biomolecular chemistry 20090921

• The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis.

  The Journal of biological chemistry 20090911

• High fidelity base pairing at the 3'-terminus.

  Journal of the American Chemical Society 20090909

• Unraveling the photochemistry of the 5-azido-2'-deoxyuridine photoaffinity label.

  The Journal of organic chemistry 20090904

• 5-Ethynyl-2'-deoxyuridine labeling detects proliferating cells in the regenerating avian cochlea.

  The Laryngoscope 20090901

• Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.

  The Biochemical journal 20090827

• Radiolabeled 5-iodo-3'-O-(17beta-succinyl-5alpha-androstan-3-one)-2'-deoxyuridine and its 5'-monophosphate for imaging and therapy of androgen receptor-positive cancers: synthesis and biological evaluation.

  Journal of medicinal chemistry 20090827

• Fishing in the (deoxyribonucleotide) pool.

  The Biochemical journal 20090827

• C5-Modified nucleosides exhibiting anticancer activity.

  Bioorganic & medicinal chemistry letters 20090815

• Base pairing configuration and stability of an oligonucleotide duplex containing a 5-chlorouracil-adenine base pair.

  Biochemistry 20090811

• Synthesis and EPR studies of 2'-deoxyuridines with alkynyl, rodlike linkages.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20090803

• Differential inhibition of single and cluster type tumor cell migration.

  Anticancer research 20090801

• Erythropoietin promotes neurological recovery after intracerebral haemorrhage in rats.

  International journal of stroke : official journal of the International Stroke Society 20090801

• A mapping of drug space from the viewpoint of small molecule metabolism.

  PLoS computational biology 20090801

• Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice.

  Radiation research 20090701

• Cell type specific applicability of 5-ethynyl-2'-deoxyuridine (EdU) for dynamic proliferation assessment in flow cytometry.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20090601

• Designing an appropriate computational model for DNA nucleoside hydrolysis: a case study of 2'-deoxyuridine.

  The journal of physical chemistry. B 20090507

• Cell cycle synchronization of Escherichia coli using the stringent response, with fluorescence labeling assays for DNA content and replication.

  Methods (San Diego, Calif.) 20090501

• Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B.

  Neuron 20090430

• No detectable hypoxia in malignant salivary gland tumors: preliminary results.

  International journal of radiation oncology, biology, physics 20090401

• Differential proteomic analysis of lymphocytes treated with mycophenolic acid reveals caspase 3-induced cleavage of rho GDP dissociation inhibitor 2.

  Therapeutic drug monitoring 20090401

• Chick embryo proliferation studies using EdU labeling.

  Developmental dynamics : an official publication of the American Association of Anatomists 20090401

• Characterization of the interaction between 2'-deoxyuridine and human serum albumin.

  Carbohydrate research 20090331

• Development of selective agonists and antagonists of P2Y receptors.

  Purinergic signalling 20090301

• Experimental neuronal migration disorders following the administration of ibotenate in hamsters: the role of the subventricular zone in the development of cortical dysplasia.

  Journal of child neurology 20090301

• A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice.

  International heart journal 20090301

• Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice.

  Human molecular genetics 20090215

• Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

  Bioorganic & medicinal chemistry letters 20090215

• Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni.

  Journal of enzyme inhibition and medicinal chemistry 20090201

• Modeling of Escherichia coli Endonuclease V structure in complex with DNA.

  Journal of molecular modeling 20090201

• Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis.

  American journal of obstetrics and gynecology 20090201

• Development history and concept of an oral anticancer agent S-1 (TS-1): its clinical usefulness and future vistas.

  Japanese journal of clinical oncology 20090101

• Facile synthesis and anti-tumor cell activity of Se-containing nucleosides.

  Nucleosides, nucleotides & nucleic acids 20090101

• The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development.

  PloS one 20090101

• Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?

  BMC public health 20090101

• Synthesis and characterization of deoxyuridine triphosphates labeled with pyrene.

  Nucleic acids symposium series (2004) 20090101

• Synthesis and properties of new fluorescent nucleosides and oligodeoxynucleotides derived from 5-formyl-2'-deoxyuridine.

  Nucleic acids symposium series (2004) 20090101

• A selective and sensitive detection of SNP between rice cultivars by using DNA photoligation.

  Nucleic acids symposium series (2004) 20090101

• A photochemical detection of methylcytosine by using hydrophobic interaction.

  Nucleic acids symposium series (2004) 20090101

• Inhibitors of MyD88-dependent proinflammatory cytokine production identified utilizing a novel RNA interference screening approach.

  PloS one 20090101

• Gene expression profiling in cells with enhanced gamma-secretase activity.

  PloS one 20090101

• Single tube, high throughput cloning of inverted repeat constructs for double-stranded RNA expression.

  PloS one 20090101

• Labeling and tracking of mesenchymal stromal cells with EdU.

  Cytotherapy 20090101

• Discrimination of carcinogens by hepatic transcript profiling in rats following 28-day administration.

  Cancer informatics 20090101

• Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors.

  PloS one 20090101

• [Effect of conjugated linoleic acid isomers on proliferation of mammary cancer cells].

  Roczniki Panstwowego Zakladu Higieny 20090101

• Study on disulfur-backboned nucleic acids: part 3. Efficient synthesis of 3',5'-dithio-2'-deoxyuridine and deoxycytidine.

  Nucleosides, nucleotides & nucleic acids 20081201

• Synthesis of 5-formyl-2'-deoxyuridine and its incorporation into oligodeoxynucleotides.

  Current protocols in nucleic acid chemistry 20081201

• Triplex formation on DNA targets: how to choose the oligonucleotide.

  Biochemistry 20081125

• Preferential tumor targeting and selective tumor cell cytotoxicity of 5-[131/125I]iodo-4'-thio-2'-deoxyuridine.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081115

• Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

  Journal of medicinal chemistry 20081113

• Application of molecular topology to the prediction of the antimalarial activity of a group of uracil-based acyclic and deoxyuridine compounds.

  International journal of pharmaceutics 20081103

• A vibrational probe for local nucleic acid environments: 5-cyano-2'-deoxyuridine.

  The journal of physical chemistry. B 20081023

• Protein binding has a large effect on radical mediated DNA damage.

  Journal of the American Chemical Society 20081001

• Gastrointestinal dysmotility in mitochondrial neurogastrointestinal encephalomyopathy is caused by mitochondrial DNA depletion.

  The American journal of pathology 20081001

• DNA with branched internal side chains: synthesis of 5-tripropargylamine-dU and conjugation by an azide-alkyne double click reaction.

  Chembiochem : a European journal of chemical biology 20080922

• Noggin expands neural stem cells in the adult hippocampus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080910

• Novel enamine derivatives of 5,6-dihydro-2'-deoxyuridine formed in reductive amination of 5-formyl-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20080901

• Spermine moiety attached to the C-5 position of deoxyuridine enhances the duplex stability of the phosphorothioate DNA/complementary DNA and shows the susceptibility of the substrate to RNase H.

  Chemical & pharmaceutical bulletin 20080901

• Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE.

  Neurology 20080826

• Comprehensive structural studies of 2',3'-difluorinated nucleosides: comparison of theory, solution, and solid state.

  Journal of the American Chemical Society 20080716

• A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.

  Biochemistry 20080708

• Lymphocyte glucocorticoid receptor resistance and depressive symptoms severity: a preliminary report.

  Progress in neuro-psychopharmacology & biological psychiatry 20080701

• A novel method based on click chemistry, which overcomes limitations of cell cycle analysis by classical determination of BrdU incorporation, allowing multiplex antibody staining.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20080701

• BLASTing small molecules--statistics and extreme statistics of chemical similarity scores.

  Bioinformatics (Oxford, England) 20080701

• [Chronic theatment with an endothelin-converting enzyme inhibitor reduces the development of hypoxia-induced pulmonary hypertension in rat].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080701

• Preparation and preliminary evaluation of novel beta-cyclodextrin/IUDR prodrug formulations.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080618

• Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies.

  BioTechniques 20080601

• The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis.

  Acta crystallographica. Section D, Biological crystallography 20080601

• 5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.

  Nucleosides, nucleotides & nucleic acids 20080601

• Pemetrexed as second-line therapy for advanced non-small-cell lung cancer (NSCLC).

  Therapeutics and clinical risk management 20080601

• Rapid and efficient DNA strand cross-linking by click chemistry.

  Chembiochem : a European journal of chemical biology 20080523

• Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945.

  Cancer research 20080515

• Effects of different activation protocols on preimplantation development, apoptosis and ploidy of bovine parthenogenetic embryos.

  Animal reproduction science 20080501

• Association of nuclear membrane protein lamin B1 with necrosis and apoptosis in cell death induced by 5-fluoro-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20080501

• Synthesis of 99mTc(CO)3-deoxyuridine derivatives as potential HSV1-tk gene expression imaging agents.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20080401

• Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.

  Bioorganic & medicinal chemistry 20080401

• Biosynthetic potentials of metabolites and their hierarchical organization.

  PLoS computational biology 20080401

• Loss of cyclin g1 expression in human uterine leiomyoma cells induces apoptosis.

  Reproductive sciences (Thousand Oaks, Calif.) 20080401

• Keeping the culture alive: the laboratory technician in mid-twentieth-century British medical research.

  Notes and records of the Royal Society of London 20080320

• Ab initio comprehensive conformational analysis of 2'-deoxyuridine, the biologically significant DNA minor nucleoside, and reconstruction of its low-temperature matrix infrared spectrum.

  The journal of physical chemistry. B 20080131

• Porphyrin conjugated to DNA by a 2'-amido-2'-deoxyuridine linkage.

  Bioorganic & medicinal chemistry letters 20080115

• Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine.

  Organic & biomolecular chemistry 20080107

• Label-retaining cells in the rat submandibular gland.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080101

• FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression.

  Muscle & nerve 20080101

• Use of halogenated precursors for simultaneous DNA and RNA detection by means of immunoelectron and immunofluorescence microscopy.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080101

• Oligothiophene-5-labeled deoxyuridines for the detection of single nucleotide polymorphisms.

  Bioconjugate chemistry 20080101

• Novel FRET-based assay to detect reverse transcriptase activity using modified dUTP analogues.

  Bioconjugate chemistry 20080101

• Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors.

  PloS one 20080101

• Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer.

  Combinatorial chemistry & high throughput screening 20080101

• Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.

  Virology journal 20080101

• RPA repair recognition of DNA containing pyrimidines bearing bulky adducts.

  Journal of molecular recognition : JMR 20080101

• The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites.

  Malaria journal 20080101

• Uracil within DNA: an actor of antiviral immunity.

  Retrovirology 20080101

• Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry.

  Nature protocols 20080101

• A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation.

  PloS one 20080101

• Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus.

  Antiviral chemistry & chemotherapy 20080101

• The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation.

  Genome biology 20080101

• Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

  The international journal of biochemistry & cell biology 20080101

• Efficient four fragment cloning for the construction of vectors for targeted gene replacement in filamentous fungi.

  BMC molecular biology 20080101

• Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate.

  BMC genomics 20080101

• Regulation of ovarian UT-OC-2 carcinoma cells by cytokines: effects on cell proliferation, activation of transcription factors and apoptosis.

  Acta obstetricia et gynecologica Scandinavica 20080101

• Synthesis and properties of oligonucleotides containing silylated pyrene derivatives.

  Nucleic acids symposium series (2004) 20080101

• Development of a novel selective detection method for 5-formyl-2'-deoxyuridine by fluorescent derivatization.

  Nucleic acids symposium series (2004) 20080101

• Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters.

  BMC evolutionary biology 20080101

• Collision induced dissociation studies of alkali metal adducts of tetracyclines and antiviral agents by electrospray ionization, hydrogen/deuterium exchange and multiple stage mass spectrometry.

  European journal of mass spectrometry (Chichester, England) 20080101

• Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice.

  Virology journal 20080101

• Dependence of antibody gene diversification on uracil excision.

  The Journal of experimental medicine 20071224

• DNA as supramolecular scaffold for porphyrin arrays on the nanometer scale.

  Journal of the American Chemical Society 20071212

• Crystal structures of human and murine deoxyribonucleotidases: insights into recognition of substrates and nucleotide analogues.

  Biochemistry 20071204

• Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury.

  Medical molecular morphology 20071201

• Synthesis of 5-(1,2,3-triazol-4-yl)-2'-deoxyuridines by a click chemistry approach: stacking of triazoles in the major groove gives increased nucleic acid duplex stability.

  Chembiochem : a European journal of chemical biology 20071123

• Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.

  British journal of cancer 20071022

• A novel ECGF1 mutation in a Thai patient with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

  Clinical neurology and neurosurgery 20070901

• The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains.

  Virology 20070801

• Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase.

  Biochimie 20070801

• Effective modulation of DNA duplex stability by reversible transition metal complex formation in the minor groove.

  Journal of the American Chemical Society 20070801

• Thymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

  FEBS letters 20070724

• Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives.

  Biochimica et biophysica acta 20070701

• Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2'-deoxyuridines fluorometrically respond to hybridization.

  Organic & biomolecular chemistry 20070621

• 5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.

  Journal of medicinal chemistry 20070614

• p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

  The Journal of biological chemistry 20070608

• Oligonucleotides containing 6-aza-2'-deoxyuridine: synthesis, nucleobase protection, pH-dependent duplex stability, and metal-DNA formation.

  The Journal of organic chemistry 20070608

• 123I-ITdU-mediated nanoirradiation of DNA efficiently induces cell kill in HL60 leukemia cells and in doxorubicin-, beta-, or gamma-radiation-resistant cell lines.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070601

• Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): biochemical features and therapeutic approaches.

  Bioscience reports 20070601

• Replication labeling with halogenated thymidine analogs.

  Current protocols in cell biology 20070601

• The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.

  FEMS microbiology letters 20070501

• High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.

  PLoS biology 20070501

• 5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells.

  Bioorganic & medicinal chemistry 20070415

• A kinetic and thermodynamic study of the glycosidic bond cleavage in deoxyuridine.

  The journal of physical chemistry. B 20070412

• Characterization and mechanism of formation of tandem lesions in DNA by a nucleobase peroxyl radical.

  Journal of the American Chemical Society 20070404

• The Ugi reaction in the generation of new nucleosides as potential antiviral and antileishmanial agents.

  Bioorganic chemistry 20070401

• DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.

  PLoS biology 20070401

• Synthesis and biodistribution of 3'-fluoro-5-[(131)I]iodo-2'-deoxyuridine: a comparative study of [(131)I]FLIdU and [(18)F]FLT.

  Nuclear medicine and biology 20070401

• Abnormal folate metabolism in foetuses affected by neural tube defects.

  Brain : a journal of neurology 20070401

• 6-Aza-2'-deoxyuridine and N(3)-anisoyl-6-aza-2'-deoxyuridine.

  Acta crystallographica. Section C, Crystal structure communications 20070301

• Treatment of mitochondrial neurogastrointestinal encephalomyopathy with dialysis.

  Archives of neurology 20070301

• Water gelation abilities of alkylbenzyltriazole-appended 2'-deoxyribonucleoside and ribonucleoside.

  Organic & biomolecular chemistry 20070221

• 5-Propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides.

  Bioorganic & medicinal chemistry letters 20070215

• Modified DNA aptamer that binds the (R)-isomer of a thalidomide derivative with high enantioselectivity.

  Journal of the American Chemical Society 20070207

• Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney.

  American journal of physiology. Cell physiology 20070201

• Cloning and characterization of an alternative splicing transcript of the gene coding for human cytidine deaminase.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20070201

• Highly sequence specific RNA terminal labeling by DNA photoligation.

  Organic & biomolecular chemistry 20070107

• Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients.

  British journal of clinical pharmacology 20070101

• Derivatization with Girard reagent T combined with LC-MS/MS for the sensitive detection of 5-formyl-2'-deoxyuridine in cellular DNA.

  Analytical chemistry 20070101

• Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum.

  BMC public health 20070101

• Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly.

  BMC structural biology 20070101

• Real-time observation of a molecular reaction mechanism of aqueous 5-Halo-2'-deoxyuridines under UV/ionizing radiation.

  Angewandte Chemie (International ed. in English) 20070101

• Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells.

  BMC cancer 20070101

• Design of dual-labeled oligonucleotide probes for SNPs genotyping.

  Nucleic acids symposium series (2004) 20070101

• Photochemical synthesis of R-shaped DNA via 5-cyanovinyldeoxyuridine.

  Nucleic acids symposium series (2004) 20070101

• Effective two-color SNP typing based on photoligation.

  Nucleic acids symposium series (2004) 20070101

• 2'-o-dimethylaminoethoxyuridine and 5-dimethylaminopropargyl deoxyuridine for at base pair recognition in triple helices.

  Nucleosides, nucleotides & nucleic acids 20070101

• Supported synthesis and functionnalization of 2''-deoxyuridine by Suzuki-Miyaura cross-coupling.

  Nucleosides, nucleotides & nucleic acids 20070101

• In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20070101

• 5-arylethynyl-2'-deoxyuridines: energy transfer and SNP-detection.

  Nucleosides, nucleotides & nucleic acids 20070101

• Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation.

  Mediators of inflammation 20070101

• Role of 99mTc-(V)DMSA in detecting tumor cell proliferation.

  Analytical chemistry insights 20070101

• Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance.

  DNA repair 20061209

• Induction of DNA synthesis in Anopheles albimanus tissue cultures in response to a Saccharomyces cerevisiae challenge.

  Archives of insect biochemistry and physiology 20061201

• Evaluation of Bacillus anthracis thymidine kinase as a potential target for the development of antibacterial nucleoside analogs.

  Biological chemistry 20061201

• Reduction in the number of astrocytes and their projections is associated with increased synaptic protein density in the hypothalamus of poorly controlled diabetic rats.

  Endocrinology 20061101

• Infusion of platelets transiently reduces nucleoside overload in MNGIE.

  Neurology 20061024

• Ferrocene-modified pyrimidine nucleosides: synthesis, structure and electrochemistry.

  Dalton transactions (Cambridge, England : 2003) 20061021

• Collisionally activated dissociation of protonated 2'-deoxycytidine, 2'-deoxyuridine, and their oxidatively damaged derivatives.

  Journal of the American Society for Mass Spectrometry 20061001

• Synthesis of DNA oligonucleotides containing 5-(mercaptomethyl)-2'-deoxyuridine moieties.

  Bioorganic & medicinal chemistry 20060915

• Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography.

  Cancer research 20060901

• Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2.

  Bioorganic & medicinal chemistry 20060815

• Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy.

  The Journal of biological chemistry 20060811

• Absence of an immediate G1/S checkpoint in primary MEFs following gamma-irradiation identifies a novel checkpoint switch.

  Cell cycle (Georgetown, Tex.) 20060801

• Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

  Journal of medicinal chemistry 20060713

• Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293.

  Chemical research in toxicology 20060701

• Synthesis and mutagenesis of the butadiene-derived N3 2'-deoxyuridine adducts.

  Chemical research in toxicology 20060701

• The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse.

  Biochemistry 20060627

• Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

  British journal of cancer 20060619

• DNA and LNA oligonucleotides containing N2'-functionalised derivatives of 2'-amino-2'-deoxyuridine.

  Bioorganic & medicinal chemistry letters 20060615

• Facile photocyclization chemistry of 5-phenylthio-2'-deoxyuridine in duplex DNA.

  Organic letters 20060608

• DNA as a supramolecular scaffold for the helical arrangement of a stack of 1-ethynylpyrene chromophores.

  Organic & biomolecular chemistry 20060607

• Characterization of BlsM, a nucleotide hydrolase involved in cytosine production for the biosynthesis of blasticidin S.

  Chembiochem : a European journal of chemical biology 20060601

• 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.

  Journal of medicinal chemistry 20060601

• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.

  Carcinogenesis 20060501

• Fluorescent 5-alkynyl-2'-deoxyuridines: high emission efficiency of a conjugated perylene nucleoside in a DNA duplex.

  Chembiochem : a European journal of chemical biology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• In vitro anti-mycobacterial activities of various 2'-deoxyuridine, 2'-arabinouridine and 2'-arabinofluoro-2'-deoxyuridine analogues: synthesis and biological studies.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20060501

• Syntheses of pyridine C-nucleosides as analogues of the natural nucleosides dC and dU.

  The Journal of organic chemistry 20060331

• 5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.

  Organic & biomolecular chemistry 20060321

• DNA intramolecular triplexes containing dT --> dU substitutions: unfolding energetics and ligand binding.

  Biochemistry 20060307

• Mitochondrial neurogastrointestinal encephalomyopathy: evidence of mitochondrial DNA depletion in the small intestine.

  Gastroenterology 20060301

• 3'-N-Alkylamino-3'-deoxy-ara-uridines: a new class of potential inhibitors of ribonuclease A and angiogenin.

  Bioorganic & medicinal chemistry 20060215

• 3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods.

  Bioorganic & medicinal chemistry letters 20060215

• Synthesis of oligonucleotides with 3'-terminal 5-(3-acylamidopropargyl)-3'-amino-2',3'-dideoxyuridine residues and their reactivity in single-nucleotide steps of chemical replication.

  The Journal of organic chemistry 20060203

• Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants.

  Journal of enzyme inhibition and medicinal chemistry 20060201

• Oxygen independent DNA interstrand cross-link formation by a nucleotide radical.

  Journal of the American Chemical Society 20060118

• Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide.

  Chemical research in toxicology 20060101

• Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion.

  Nutrition (Burbank, Los Angeles County, Calif.) 20060101

• Viruses take center stage in cellular evolution.

  Genome biology 20060101

• [Study of drugs against neoplastic metastasis].

  Magyar onkologia 20060101

• A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.

  Journal of experimental botany 20060101

• [Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)].

  Casopis lekaru ceskych 20060101

• Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.

  Antiviral chemistry & chemotherapy 20060101

• Nucleotide insertion opposite a cyclobutane pyrimidine dimer analogue caused from photoligation by a replicative DNA polymerase.

  Nucleic acids symposium series (2004) 20060101

• Synthesis and properties of novel PRODAN-labeled uridine.

  Nucleic acids symposium series (2004) 20060101

• [The innate antiretroviral defense of human cells, based on the DNA editing].

  Postepy biochemii 20060101

• Paradigm development: comparative and predictive 3D modeling of HIV-1 Virion Infectivity Factor (Vif).

  Bioinformation 20060101

• Synthesis of a 2'-Se-uridine phosphoramidite and its incorporation into oligonucleotides for structural study.

  Organic letters 20051208

• Comparison of Py*+/dU*- charge transfer state dynamics in 5-(1-pyrenyl)-2'-deoxyuridine nucleoside conjugates with amido-, ethylenyl-, and ethynyl linkers.

  The journal of physical chemistry. A 20051208

• Synthesis and in vitro antileishmanial activity of 5-substituted-2'-deoxyuridine derivatives.

  Bioorganic chemistry 20051201

• Yersiniophage phiR1-37 is a tailed bacteriophage having a 270 kb DNA genome with thymidine replaced by deoxyuridine.

  Microbiology (Reading, England) 20051201

• Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2'-deoxyuridine and 5-chloro-2'-deoxyuridine.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20051101

• Emx2 regulates mammalian reproduction by altering endometrial cell proliferation.

  Molecular endocrinology (Baltimore, Md.) 20051101

• Increased muscle nucleoside levels associated with a novel frameshift mutation in the thymidine phosphorylase gene in a Spanish patient with MNGIE.

  Neuromuscular disorders : NMD 20051101

• Nucleic acid with guanidinium modification exhibits efficient cellular uptake.

  Angewandte Chemie (International ed. in English) 20051021

• A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.

  British journal of cancer 20051017

• Late-onset MNGIE due to partial loss of thymidine phosphorylase activity.

  Annals of neurology 20051001

• Site-selective DNA hydrolysis by Ce(IV)-EDTA with the use of one oligonucleotide additive bearing two monophosphates.

  Chembiochem : a European journal of chemical biology 20051001

• Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target.

  Journal of medicinal chemistry 20050922

• Incorporation of cationic chains in the Dickerson-Drew dodecamer: correlation of energetics, structure, and ion and water binding.

  Biochemistry 20050920

• Electron transfer chemistry between DNA and DNA-binding tripeptides.

  Biochemistry 20050906

• The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells.

  Journal of neuro-oncology 20050901

• Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050801

• Oxidation of 5-hydroxypyrimidine nucleosides to 5-hydroxyhydantoin and its alpha-hydroxy-ketone isomer.

  Chemical research in toxicology 20050801

• Thymidine phosphorylase mutations cause instability of mitochondrial DNA.

  Gene 20050718

• Photoinduced DNA end capping via N3-methyl-5-cyanovinyl-2'-deoxyuridine.

  Chemical communications (Cambridge, England) 20050707

• Template-directed DNA photoligation via alpha-5-cyanovinyldeoxyuridine.

  Organic letters 20050707

• Mitochondrial deoxynucleotide pools in quiescent fibroblasts: a possible model for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

  The Journal of biological chemistry 20050701

• Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase.

  Structure (London, England : 1993) 20050701

• Charge transfer excited-state dynamics in DNA duplexes substituted with an ethynylpyrenyldeoxyuridine electron source and a fluorodeoxyuridine electron trap.

  The journal of physical chemistry. B 20050623

• ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.

  Biochimica et biophysica acta 20050615

• Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase.

  Journal of immunology (Baltimore, Md. : 1950) 20050615

• Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050605

• Proton affinity ladder for uridine and analogs: influence of the hydroxyl group on the sugar ring conformation.

  Journal of mass spectrometry : JMS 20050601

• A dual selection based, targeted gene replacement tool for Magnaporthe grisea and Fusarium oxysporum.

  Fungal genetics and biology : FG & B 20050601

• Structure of B-DNA with cations tethered in the major groove.

  Biochemistry 20050524

• beta-Selective synthesis of 2'-deoxy-5,6-dihydro-4-thiouridine, a precursor of the unstable nucleoside product of ionising radiation damage 2'-deoxy-5,6-dihydrocytidine.

  Organic & biomolecular chemistry 20050507

• Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.

  Current biology : CB 20050412

• Determining the origin of the stabilization of DNA by 5-aminopropynylation of pyrimidines.

  Biochemistry 20050329

• Reductive electron transfer in phenothiazine-modified DNA is dependent on the base sequence.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20050304

• Differential incorporation of halogenated deoxyuridines during UV-induced DNA repair synthesis in human cells.

  DNA repair 20050302

• Rapid identification of emerging pathogens: coronavirus.

  Emerging infectious diseases 20050301

• Phosphodiester cleavage of guanylyl-(3',3')-(2'-amino-2'-deoxyuridine): rate acceleration by the 2'-amino function.

  Journal of the American Chemical Society 20050216

• A phase II study of raltitrexed and gemcitabine in patients with advanced pancreatic carcinoma.

  British journal of cancer 20050214

• The fate of heterologous CD4+ T cells during Leishmania donovani infection.

  European journal of immunology 20050201

• dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

  Structure (London, England : 1993) 20050201

• Active site plasticity of endonuclease V from Salmonella typhimurium.

  Biochemistry 20050118

• A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells.

  Bioorganic & medicinal chemistry letters 20050103

• APOBEC3G & HTLV-1: inhibition without deamination.

  Retrovirology 20050101

• Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast.

  BMC genetics 20050101

• APOBEC3G targets human T-cell leukemia virus type 1.

  Retrovirology 20050101

• Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.

  Virology journal 20050101

• CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.

  BMC bioinformatics 20050101

• Use of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy.

  Retrovirology 20050101

• Megaloblastosis: from morphos to molecules.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101

• Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines.

  Nucleosides, nucleotides & nucleic acids 20050101

• Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomono phosphate as a potential thymidylate synthase inhibitor.

  Nucleosides, nucleotides & nucleic acids 20050101

• A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame.

  Virology journal 20050101

• Immunohistochemical detection of dUTPase in intracranial tumors.

  Pathology, research and practice 20050101

• [Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives].

  Bioorganicheskaia khimiia 20050101

• Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture.

  Journal of biomedicine & biotechnology 20050101

• DNA interstrand cross-links from modified nucleotides: mechanism and application.

  Nucleic acids symposium series (2004) 20050101

• Pyrene-labeled deoxyuridine and deoxyadenosine: fluorescent discriminating phenomena in their duplex and hairpin oligonucleotides.

  Nucleic acids symposium series (2004) 20050101

• RNA template-directed photoligation via 5-carboxyvinyl-2'-deoxyuridine.

  Nucleic acids symposium series (2004) 20050101

• Reactivity of 2'-deoxyuridin-1'-yl radical in various DNA structures.

  Nucleic acids symposium series (2004) 20050101

• SNPs typing by base-discriminating fluorescence DNA probe.

  Nucleic acids symposium series (2004) 20050101

• Mild generation of 5-(2'-deoxyuridinyl)methyl radical from a phenyl selenide precursor.

  Organic letters 20041223

• Induction of gene mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue.

  Mutation research 20041221

• Induction of A:T to G:C transition mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue, in the bone marrow of Muta Mouse.

  Mutation research 20041221

• Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase.

  Biochemistry 20041102

• In vivo evidence for apoptosis, but not inflammation in the hindlimb muscle of neuropathic rats.

  Pain 20041101

• A homogeneous time-resolved fluorescence detection of telomerase activity.

  Analytical biochemistry 20041001

• Calorimetric determination of thermodynamic parameters of 2'-dUMP binding to Leishmania major dUTPase.

  Biochimica et biophysica acta 20041001

• Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.

  Journal of natural products 20041001

• Thymidine phosphorylase deficiency causes MNGIE: an autosomal recessive mitochondrial disorder.

  Nucleosides, nucleotides & nucleic acids 20041001

• Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum.

  Nucleosides, nucleotides & nucleic acids 20041001

• Stabilizing or destabilizing oligodeoxynucleotide duplexes containing single 2'-deoxyuridine residues with 5-alkynyl substituents.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20040820

• Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

  Biochemical pharmacology 20040815

• Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide.

  American journal of physiology. Lung cellular and molecular physiology 20040801

• Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma.

  Gut 20040801

• Endogenous expression of activation-induced cytidine deaminase in cell line WEHI-231.

  Journal of immunology (Baltimore, Md. : 1950) 20040801

• Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes.

  Analytical biochemistry 20040701

• Oxidation of 5-hydroxy-2'-deoxyuridine into isodialuric acid, dialuric acid, and hydantoin products.

  Journal of the American Chemical Society 20040602

• Pyrene-labeled base-discriminating fluorescent DNA probes for homogeneous SNP typing.

  Journal of the American Chemical Society 20040421

• The regulation of somatic hypermutation.

  Current opinion in immunology 20040401

• Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040401

• Effect of GLP-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion.

  Pancreas 20040301

• Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218

• Lysine directed cross-linking of viral DNA-RNA:DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase.

  Biochemistry 20040210

• The first direct evaluation of the two-active site mechanism for chitin synthase.

  The Journal of organic chemistry 20040206

• In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2'-deoxyuridine activated by hypoxic irradiation.

  International journal of radiation oncology, biology, physics 20040201

• Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

  European journal of immunology 20040201

• Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.

  British journal of cancer 20040126

• ND5 is a hot-spot for multiple atypical mitochondrial DNA deletions in mitochondrial neurogastrointestinal encephalomyopathy.

  Human molecular genetics 20040101

• Definitive diagnosis of mitochondrial neurogastrointestinal encephalomyopathy by biochemical assays.

  Clinical chemistry 20040101

• Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a disease of two genomes.

  The neurologist 20040101

• Use of folic acid casei medium reveals trimethoprim susceptibility of Lactobacillus species.

  Letters in applied microbiology 20040101

• Relationship of cell proliferation (Ki-67) to 99mTc-(V)DMSA uptake in breast cancer.

  Breast cancer research : BCR 20040101

• A new approach for the synthesis of novel 5-substituted isodeoxyuridine analogs.

  Nucleosides, nucleotides & nucleic acids 20040101

• Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20040101

• Molecular modeling of the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

  Nucleosides, nucleotides & nucleic acids 20040101

• Tissue-specific spatial organization of genomes.

  Genome biology 20040101

• [Monomers for oligonucleotide synthesis with linkers carrying reactive residues: II. Synthesis of phosphoamidites based of uridine and cytosine and containing a linker with methoxyoxalamide groups in position 2'].

  Bioorganicheskaia khimiia 20040101

• Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells.

  Retrovirology 20040101

• [Antisense oligonucleotides with antitumor activity].

  Magyar onkologia 20040101

• [Potentiation of 5-fluorouracil efficacy. Molecular mechanisms playing a role in the cytotoxic action of 5-fluorouracil and 5-ethyl-2'-deoxyuridine (EUdR) combination].

  Magyar onkologia 20040101

• Immobilization and stabilization of recombinant multimeric uridine and purine nucleoside phosphorylases from Bacillus subtilis.

  Biomacromolecules 20040101

• Reversible DNA photoligation via alpha-5-cyanovinyldeoxyuridine.

  Nucleic acids symposium series (2004) 20040101

• X-ray analyses of DNA duplexes containing 5-(N-aminohexyl)carbamoyl modifications.

  Nucleic acids symposium series (2004) 20040101

• Novel low-molecular-weight hydrogelators based on 2'-deoxyuridine.

  Chemical communications (Cambridge, England) 20031207

• Replication labeling patterns and chromosome territories typical of mammalian nuclei are conserved in the early metazoan Hydra.

  Chromosoma 20031201

• The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.

  Nature medicine 20031101

• Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth.

  Molecular microbiology 20031101

• Independent generation of 5-(2'-deoxycytidinyl)methyl radical and the formation of a novel cross-link lesion between 5-methylcytosine and guanine.

  Journal of the American Chemical Society 20031022

• Regulation of bovine corneal endothelial cell cycle by transforming growth factor-beta.

  Acta ophthalmologica Scandinavica 20031001

• Pharmacokinetics and metabolism of 5-125I-iodo-4'-thio-2'-deoxyuridine in rodents.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031001

• Proliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol.

  Toxicology and applied pharmacology 20031001

• Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations.

  Chemical research in toxicology 20030901

• Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by schiff base-mediated crosslinking.

  Bioorganic & medicinal chemistry letters 20030901

• 5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay.

  The Journal of biological chemistry 20030829

• Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

  British journal of cancer 20030804

• Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.

  Chembiochem : a European journal of chemical biology 20030804

• Identification of a novel human uridine phosphorylase.

  Biochemical and biophysical research communications 20030718

• Modified DNA bearing 5(methoxycarbonylmethyl)-2'-deoxyuridine: preparation by PCR with thermophilic DNA polymerase and postsynthetic derivatization.

  Chembiochem : a European journal of chemical biology 20030707

• Conformational structures and vibrational spectra of isolated pyrimidine nucleosides: Fourier transform infrared matrix isolation study of 2-deoxyuridine.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030701

• Photochemical cross-linking of Escherichia coli Fpg protein to DNA duplexes containing phenyl(trifluoromethyl)diazirine groups.

  European journal of biochemistry 20030701

• Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders.

  Clinical chemistry and laboratory medicine 20030701

• Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines.

  British journal of cancer 20030616

• Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency.

  The Journal of clinical investigation 20030615

• DNA deamination mediates innate immunity to retroviral infection.

  Cell 20030613

• Immunomodulation of hepatic ischemic injury via increased Bcl-X(L) and decreased Bcl-X(S).

  The Journal of surgical research 20030601

• Synthesis and enzymatic transformations of 5-halo-6-methoxy-5,6-dihydro derivatives of 5-[1-methoxy-2-halo (or 2,2-dihalo)ethyl]-2'-deoxyuridines as potential herpes simplex virus inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20030601

• Independent generation and study of 5,6-Dihydro-2'-deoxyuridin-6-yl, a member of the major family of reactive intermediates formed in DNA from the effects of gamma-radiolysis.

  The Journal of organic chemistry 20030530

• 2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.

  Journal of the National Cancer Institute 20030507

• Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges.

  Organic & biomolecular chemistry 20030507

• Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues.

  Antiviral chemistry & chemotherapy 20030501

• Oligo-2'-deoxyribonucleotides containing uracil modified at the 5-position with linkers ending with guanidinium groups.

  Journal of the American Chemical Society 20030416

• A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030401

• The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase.

  The Journal of biological chemistry 20030328

• Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiency.

  Biochemical and biophysical research communications 20030328

• Effect of pH and sodium chloride on the strength and selectivity of the interaction of gamma [correction for tau] -cyclodextrin with some antisense nucleosides.

  International journal of pharmaceutics 20030326

• DFT analysis of NMR scalar interactions across the glycosidic bond in DNA.

  Journal of the American Chemical Society 20030326

• Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: 'nitric oxide donor' agents for evaluation as anticancer and antiviral agents.

  Journal of medicinal chemistry 20030313

• A balanced deoxyribonucleoside mixture increased the rate of DNA incorporation of 5-[125I]Iodo-2'-deoxyuridine in glioblastoma cells.

  Cancer biotherapy & radiopharmaceuticals 20030201

• Pathways of accumulation and repair of deoxyuridine residues in DNA of higher and lower organisms.

  Biochemistry. Biokhimiia 20030201

• Evaluation of 5-[1-(2-halo(or nitro)ethoxy-2-iodoethyl)]-2'-deoxyuridines as inhibitors of herpes simplex virus.

  Journal of enzyme inhibition and medicinal chemistry 20030201

• Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies.

  Bioorganic & medicinal chemistry 20030102

• Microwave-assisted synthesis of O'-adamantylated uracil-derived nucleosides.

  Nucleosides, nucleotides & nucleic acids 20030101

• Synthesis of a novel aldehyde: 4-O-methyl-5-formylmethyl-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20030101

• The effects of middle cerebral artery occlusion on central nervous system apoptotic events in normal and diabetic rats.

  International journal of experimental diabesity research 20030101

• [Effects of childhood nutrition on adult health].

  Allergologia et immunopathologia 20030101

• [Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives].

  Bioorganicheskaia khimiia 20030101

• The NMR studies of substituent effects on the N-H...N hydrogen bond in duplex DNA using 2'-deoxynebularine and 15N labeled 5-substituted-2'-deoxyuridine base pairs.

  Nucleic acids research. Supplement (2001) 20030101

• Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

  Nucleosides, nucleotides & nucleic acids 20030101

• New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides.

  Nucleosides, nucleotides & nucleic acids 20030101

• Synthesis of modified DNAs bearing two different fluorescent probes and its application to fluorescence resonance energy transfer.

  Nucleosides, nucleotides & nucleic acids 20030101

• Hydrolytic reactions of diribonucleoside 3',5'-(3'-N-phosphoramidates): kinetics and mechanisms for the P-O and P-N bond cleavage of 3'-amino-3'-deoxyuridylyl-3',5'-uridine.

  Journal of the American Chemical Society 20021204

• DNA duplexes containing photoactive derivatives of 2'-deoxyuridine as photocrosslinking probes for EcoRII DNA methyltransferase-substrate interaction.

  Journal of biomolecular structure & dynamics 20021201

• Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE).

  Journal of inherited metabolic disease 20021101

• Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3'-deoxycytidine.

  Antiviral chemistry & chemotherapy 20021101

• 5-amino-2'-deoxyuridine, a novel thymidine analogue for high-resolution footprinting of protein-DNA complexes.

  Organic letters 20021031

• Radiolabelled thymidines and deoxyuridines for measuring cellular proliferation in tumours--an update.

  Nuclear medicine communications 20021001

• Synthesis of 5-(pyridinyl and pyridiniumyl)-2'-deoxyuridine nucleosides: reversible electron traps for DNA.

  Nucleosides, nucleotides & nucleic acids 20021001

• Rationale of 5-(125)I-iodo-4'-thio-2'-deoxyuridine as a potential iodinated proliferation marker.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020901

• Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

  FEBS letters 20020828

• Repair of flexor tendon defects of rabbit with tissue engineering method.

  Chinese journal of traumatology = Zhonghua chuang shang za zhi 20020801

• Formation of 2'-deoxyuridine hydrates upon exposure of nucleosides to gamma radiation and UVC-irradiation of isolated and cellular DNA.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20020801

• Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending.

  Journal of the American Chemical Society 20020724

• Fluorescent 1,10-phenanthroline-containing oligonucleotides distinguish between perfect and mismatched base pairing.

  Organic letters 20020711

• Changes in nuclear matrix proteins during the senescence-like phenomenon induced by 5-chlorodeoxyuridine in HeLa cells.

  Experimental gerontology 20020701

• Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.

  Biochemistry 20020611

• Chemical synthesis and biochemical properties of oligonucleotides that contain the (5'S,5S,6S)-5',6-cyclo-5-hydroxy-5,6-dihydro-2'-deoxyuridine DNA lesion.

  Chembiochem : a European journal of chemical biology 20020603

• Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis.

  The Journal of biological chemistry 20020503

• Unlabelled iododeoxyuridine increases the rate of uptake of [125I]iododeoxyuridine in human xenografted glioblastomas.

  European journal of nuclear medicine and molecular imaging 20020401

• Water mediated Dickerson-Drew-type crystal of DNA dodecamer containing 2'-deoxy-5-formyluridine.

  Biophysical chemistry 20020328

• Binding properties of oligonucleotides containing a modified 2'-deoxyuridine with a thymine ended linker to pair with 2'-deoxyadenosine.

  Bioorganic & medicinal chemistry letters 20020325

• Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: the protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5' side.

  Journal of the American Chemical Society 20020313

• One-pot two-step enzymatic coupling of pyrimidine bases to 2-deoxy-D-ribose-5-phosphate. A new strategy in the synthesis of stable isotope labeled deoxynucleosides.

  The Journal of organic chemistry 20020308

• The Escherichia coli tRNA-guanine transglycosylase can recognize and modify DNA.

  The Journal of biological chemistry 20020301

• Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution.

  Biochemistry 20020226

• Synthesis of dicobalt hexacarbonyl 5-p-tolylethynyl-2'-deoxyuridine.

  Chemical communications (Cambridge, England) 20020221

• 5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity.

  Bioorganic & medicinal chemistry letters 20020211

• Prognostic value of thymidine phosphorylase expression in breast carcinoma.

  International journal of cancer 20020201

• Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020101

• [Chromosomal abnormalities in lymphocytes from a patient with Werner's syndrome in intact culture and after treatment with halogenated analogs of thymidine].

  Tsitologiia 20020101

• [4'-Thio-5-ethyl-2'-deoxyuridine 5'-phosphonates: synthesis and antiviral activity].

  Bioorganicheskaia khimiia 20020101

• Prolactin signaling and Stat5: going their own separate ways?

  Breast cancer research : BCR 20020101

• Synthesis of 5-(2,2'-bipyridinyl and 2,2'-bipyridinediiumyl)-2'-deoxyuridine nucleosides: precursors to metallo-DNA conjugates.

  Nucleosides, nucleotides & nucleic acids 20020101

• Conformation dependent DNA photoligation via sensitizer tethered 5-carboxyvinyluracil.

  Nucleic acids research. Supplement (2001) 20020101

• Glycine rich P-loop motif in deoxyuridine pyrophosphatase.

  Current protein & peptide science 20011201

• Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.

  Nature genetics 20011101

• C5-(1-propynyl)-2'-deoxy-pyrimidines enhance mismatch penalties of DNA:RNA duplex formation.

  Biochemistry 20011023

• Uracil-DNA glycosylase acts by substrate autocatalysis.

  Nature 20011018

• Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.

  Journal of medicinal chemistry 20011011

• Incorporation of 2'-deoxy-5-(trifluoromethyl)uridine and 5-cyano-2'-deoxyuridine into DNA.

  Bioorganic & medicinal chemistry letters 20010917

• Synthesis of certain 2'-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5'; evaluation as potential dUTP analogues.

  Nucleosides, nucleotides & nucleic acids 20010901

• Synthesis and evaluation of a C-glycosyl nucleoside as an inhibitor of chitin synthase.

  Carbohydrate research 20010830

• Reduced thymocyte proliferation but not increased apoptosis as a possible cause of thymus atrophy in iron-deficient mice.

  The British journal of nutrition 20010801

• Reconstructing the substrate for uracil DNA glycosylase: tracking the transmission of binding energy in catalysis.

  Biochemistry 20010626

• Cell proliferation, apoptosis, NF-kappaB expression, enzyme, protein, and weight changes in livers of burned rats.

  American journal of physiology. Gastrointestinal and liver physiology 20010601

• Interaction of a group II intron ribonucleoprotein endonuclease with its DNA target site investigated by DNA footprinting and modification interference.

  Journal of molecular biology 20010601

• Crystallization and preliminary crystallographic analysis of deoxyuridine 5'-triphosphate nucleotidohydrolase from Bacillus subtilis.

  Acta crystallographica. Section D, Biological crystallography 20010601

• 1H NMR conformational study of a variety of alpha-anomers of C5-substituted 2'-deoxyuridines: comparison to their antiherpetic beta counterparts.

  Biochemical and biophysical research communications 20010525

• Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.

  Mutation research 20010509

• Palladium-mediated C5 substitution of pyrimidine nucleosides.

  Current protocols in nucleic acid chemistry 20010501

• A 2'-acylamido cap that increases the stability of oligonucleotide duplexes.

  Organic letters 20010405

• Cytosolic high K(m) 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism.

  The Journal of biological chemistry 20010302

• Active intestinal absorption of nucleosides by Na+-dependent transport across the brush border membrane in cows.

  Journal of dairy science 20010301

• Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.

  Bioorganic & medicinal chemistry 20010301

• The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue.

  Biochemistry 20010220

• 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism.

  Toxicology letters 20010203

• Crystallization and preliminary X-ray analysis of a DNA dodecamer containing 2'-deoxy-5-formyluridine; what is the role of magnesium cation in crystallization of Dickerson-type DNA dodecamers?

  Acta crystallographica. Section D, Biological crystallography 20010201

• G-protein expression and intimal hyperplasia after arterial injury: a role for Galpha(i) proteins.

  Journal of vascular surgery 20010201

• Synthesis of 2'-modified oligodeoxynucleotides via on-column conjugation.

  The Journal of organic chemistry 20010126

• A phase I study of nolatrexed dihydrochloride in children with advanced cancer. A United Kingdom Children's Cancer Study Group Investigation.

  British journal of cancer 20010101

• Synthesis of the first ferrocene-labeled dideoxynucleotide and its use for 3'-redox end-labeling of 5'-modified single-stranded oligonucleotides.

  Bioconjugate chemistry 20010101

• Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

  Nucleosides, nucleotides & nucleic acids 20010101

• 5-(phenylthiomethyl)-2'-deoxyuridine as an efficient photoreactive precursor to generate single and multiple lesions within DNA fragments.

  Nucleosides, nucleotides & nucleic acids 20010101

• Synthesis of 5-methylamino-2'-deoxyuridine derivatives.

  Nucleosides, nucleotides & nucleic acids 20010101

• Dynamic SIMS ion microscopy imaging of intracellular boron accumulation from carboranyl nucleosides in glioma cells.

  Anticancer research 20010101

• Synthesis of 5-substituted [N3-15N]-pyrimidine nucleosides: Developing model systems for NMR studies of substituent effects on the N-H...N hydrogen bond in duplex DNA.

  Nucleic acids research. Supplement (2001) 20010101

• Investigation of antisense DNA having C-5 polyamine substituted 2'-deoxyuridine derivative.

  Nucleic acids research. Supplement (2001) 20010101

• Evidence for a Schiff base formation of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine.

  Nucleic acids research. Supplement (2001) 20010101

• Template directed DNA photoligation via substituted 2'-deoxyuridine.

  Nucleic acids research. Supplement (2001) 20010101

• X-ray analyses of DNA dodecamers containing 2'-deoxy-5-formyluridine.

  Nucleic acids research. Supplement (2001) 20010101

• Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes.

  The Biochemical journal 20001015

• Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.

  Journal of medicinal chemistry 19990826

• Novel spironucleosides: 1',3'-thiazolidine-2'-spiro-3'-3'-deoxyuridine derivatives.

  Nucleosides & nucleotides 19980601

• Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.

  Nucleosides & nucleotides 19980101

• Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

  Journal of medicinal chemistry 19961122

• Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines.

  Antiviral research 19960501

• Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.

  Antiviral research 19940801

• Synthesis of 5-[1-hydroxy (or methoxy)-2,2-dihaloethyl]-2'- deoxyuridines with antiviral and cytotoxic activity.

  Antiviral research 19940801

• New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

  The Journal of biological chemistry 19940722

• Synthesis, biotransformation, pharmacokinetics, and antiviral properties of 5-ethyl-5-halo-6-methoxy-5,6-dihydro-2'-deoxyuridine diastereomers.

  Biochemical pharmacology 19940429

• Cellular pharmacology and biological activity of 5-carboranyl-2'-deoxyuridine.

  International journal of radiation oncology, biology, physics 19940330

• Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.

  Journal of medicinal chemistry 19930820

• Metabolism and mode of selective inhibition of human immunodeficiency virus replication by 3'-azido-2',3'-dideoxy-5-iodouridine and 3'-azido-2',3'-dideoxy-5-bromouridine.

  Biochemical pharmacology 19930107

• Inhibition of herpes simplex virus types 1 and 2 replication in vitro by mercurithio analogs of deoxyuridine.

  Antiviral research 19910901

• 5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.

  Journal of medicinal chemistry 19910801

• Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.

  Journal of medicinal chemistry 19910801

• Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.

  Journal of medicinal chemistry 19910601

• Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine.

  Journal of medicinal chemistry 19910401

• Mechanism of action of 5-(2-chloroethyl)-2'-deoxyuridine, a selective inhibitor of herpes simplex virus replication.

  Molecular pharmacology 19900501

• Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors.

  Antiviral research 19900301

• Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.

  Journal of medicinal chemistry 19900201

• Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.

  Journal of medicinal chemistry 19890801

• Synthesis and antiviral activity of several 2,5'-anhydro analogues of 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-azido-2',3'-dideoxy-5-halouridines, and 3'-deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus.

  Journal of medicinal chemistry 19890801

• Synthesis of 5-[1-hydroxy(or methoxy)-2-bromo(or chloro)ethyl]-2'-deoxyuridines and related halohydrin analogues with antiviral and cytotoxic activity.

  Journal of medicinal chemistry 19890501

• Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.

  Proceedings of the National Academy of Sciences of the United States of America 19890201

• Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.

  Journal of medicinal chemistry 19880901

• Specific phosphorylation of 5-ethyl-2'-deoxyuridine by herpes simplex virus-infected cells and incorporation into viral DNA.

  The Journal of biological chemistry 19871105

• 2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.

  Journal of medicinal chemistry 19870701

• In vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil.

  Antiviral research 19870601

• Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.

  Journal of medicinal chemistry 19860501

• Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.

  Journal of medicinal chemistry 19860201

• Synthesis and antiviral activity of the carbocyclic analogues of 5-ethyl-2'-deoxyuridine and of 5-ethynyl-2'-deoxyuridine.

  Journal of medicinal chemistry 19860101

• 5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.

  Journal of medicinal chemistry 19851101

• Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus.

  Antimicrobial agents and chemotherapy 19850801

• Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

  Journal of medicinal chemistry 19850501

• Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with trifluorothymidine, phosphonoformate and acycloguanosine against herpes simplex viruses.

  Antiviral research 19850201

• 5-Ethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation demonstrated with human leukemic cells and PHA-stimulated lymphocytes in vitro.

  Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 19850101

• Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.

  Journal of medicinal chemistry 19840301

• Comparison of the antiviral effects of 5-methoxymethyldeoxyuridine-5'-monophosphate with adenine arabinoside-5'-monophosphate.

  Antiviral research 19830901

• Structural requirements of olefinic 5-substituted deoxyuridines for antiherpes activity.

  Journal of medicinal chemistry 19830901

• Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2.

  Antimicrobial agents and chemotherapy 19830501

• Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.

  Journal of medicinal chemistry 19830201

• Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.

  Journal of medicinal chemistry 19821101

• Antiherpes activity of [E]-5-(1-propenyl)-2'-deoxyuridine and 5-(1-propenyl)-1-beta-D-arabinofuranosyluracil.

  Antiviral research 19811101

• Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.

  Journal of medicinal chemistry 19810401

• Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2'-deoxyuridine and their 5'-phosphates.

  Biochemical pharmacology 19810301

• Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy.

  Antimicrobial agents and chemotherapy 19801201

• Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2.

  Antimicrobial agents and chemotherapy 19800401

• Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.

  Journal of medicinal chemistry 19800301

• Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines.

  Biochemical pharmacology 19791115

• Effect of treatment with 5-ethyl-2'-deoxyuridine on herpes simplex virus encephalitis in normal and immunosuppressed mice.

  Antimicrobial agents and chemotherapy 19781101

• 5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.

  Antimicrobial agents and chemotherapy 19780301

• 5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.

  Journal of medicinal chemistry 19780201

• Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.

  Journal of medicinal chemistry 19770701

• Antiviral action and cellular toxicity of four thymidine analogues: 5-ethyl-,5-vinyl-, 5-propyl-, and 5-allyl-2'- deoxyuridine.

  Antimicrobial agents and chemotherapy 19760701

• Effect of cytosine, arabinoside, iododeoxyuridine, ethyldeoxyuridine, thiocyanatodeoxyuridine, and ribavirin on tail lesion formation in mice infected with vaccinia virus.

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19760301

• Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice.

  Cancer research 19750601

• Mechanism of triamterene-induced megaloblastosis.

  Annals of internal medicine 19700901

• Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.

  The New England journal of medicine 19690612

• The antiviral activity of 9-beta-D-arabinofuranosyladenine (ARA-A).

  Chemotherapia 19680101

• Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent.

  Journal of medicinal chemistry 19660501