953411-10-4 | 7-Bromo-1h-indazol-5-amine

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$18.00	$13.00
250mg	95%	in stock	$21.00	$15.00
1g	95%	in stock	$22.00	$16.00

Description

• Catalog Number: AC69536
• Chemical Name: 7-Bromo-1h-indazol-5-amine
• CAS Number: 953411-10-4
• Molecular Formula: C7H6BrN3
• Molecular Weight: 212.0466
• MDL Number: MFCD08275114
• SMILES: Nc1cc(Br)c2c(c1)cn[nH]2

Upstream Synthesis Route

The upstream synthesis route for 7-Bromo-1H-indazol-5-amine can be outlined as follows:

1. Start with a readily available starting material such as o-phenylenediamine and react it with a suitable diazo compound to synthesize an indazole scaffold through a Diazo-transfer reaction or Fisher Indole Synthesis.

2. Once the indazole core is synthesized, brominate at the 7-position using N-bromosuccinimide (NBS) in the presence of a radical starter such as azobisisobutyronitrile (AIBN) under appropriate conditions to obtain 7-bromoindazole.

3. The last step involves the introduction of the amine group at the 5-position which can be achieved via nucleophilic substitution of an appropriate leaving group (possibly a nitro or halide group) at the 5-position with an amine source under suitable reaction conditions.

Each step in this synthesis requires careful control of reaction conditions including temperature, pH, and use of protective groups if necessary to ensure the correct regiochemistry and to protect the functional groups that are sensitive or not involved in the current reaction step. The overall yield and purity of 7-Bromo-1H-indazol-5-amine are dependent on the efficiency of each of these steps and the purification methods employed.