956014-19-0 | 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea

Packsize	Purity	Availability	Price	Discounted Price
1mg	≥95%	in stock	$42.00	$29.00
5mg	≥95%	in stock	$129.00	$90.00
10mg	≥95%	in stock	$197.00	$138.00
50mg	95%	in stock	$382.00	$268.00
1000mg	98% by HPLC	in stock	$6,312.00	$4,419.00

Description

• Catalog Number: AB47617
• Chemical Name: 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea
• CAS Number: 956014-19-0
• Molecular Formula: C16H9BrF6N6S
• Molecular Weight: 511.2423
• MDL Number: MFCD24387114
• SMILES: S=C(Nc1ccc(cc1c1nn[nH]n1)Br)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F

Computed Properties

• Complexity: 586
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: 4.8

Literature

• Localization of large conductance calcium-activated potassium channels and their effect on calcitonin gene-related peptide release in the rat trigemino-neuronal pathway.

  Neuroscience 20100602

• Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo.

  Naunyn-Schmiedeberg's archives of pharmacology 20100301

• BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100201

• NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats.

  British journal of pharmacology 20091101

• Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury.

  Pflugers Archiv : European journal of physiology 20090301

• The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

  Molecular pharmacology 20071001