957-75-5 | 5-Bromouridine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$17.00	$12.00
5g	98%	in stock	$55.00	$39.00
25g	98%	in stock	$167.00	$117.00
100g	98%	in stock	$597.00	$418.00

Description

• Catalog Number: AC93978
• Chemical Name: 5-Bromouridine
• CAS Number: 957-75-5
• Molecular Formula: C9H11BrN2O6
• Molecular Weight: 323.0974
• MDL Number: MFCD00006528
• SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(Br)c(=O)[nH]c1=O

Computed Properties

• Complexity: 414
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 2
• XLogP3: -1.1

Literature

• Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals.

  Genome research 20120501

• PCR synthesis of double stranded DNA labeled with 5-bromouridine. A step towards finding a bromonucleoside for clinical trials.

  Journal of pharmaceutical and biomedical analysis 20111205

• Electron transfer through RNA: chemical probing of dual distance dependence.

  Bioorganic & medicinal chemistry 20111115

• Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos.

  Biology of reproduction 20111101

• Regulation of estrogen sulfotransferase expression by confluence of MCF10A breast epithelial cells: role of the aryl hydrocarbon receptor.

  The Journal of pharmacology and experimental therapeutics 20111101

• A method for detecting genetic toxicity using the RNA synthesis response to DNA damage.

  The Journal of toxicological sciences 20111001

• Transcriptional activity of nuclei in 2-cell blocked mouse embryos.

  Tissue & cell 20110801

• Nucleotides function as endogenous chemical sensors for oxidative stress signaling.

  Journal of clinical biochemistry and nutrition 20110101

• Enzymatic synthesis of long double-stranded DNA labeled with haloderivatives of nucleobases in a precisely pre-determined sequence.

  BMC biochemistry 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication, and transcriptional activity in cloned mouse embryos.

  Biology of reproduction 20100901

• Direct evidence for postmeiotic transcription during Drosophila melanogaster spermatogenesis.

  Genetics 20100901

• A non-isotopic assay uses bromouridine and RNA synthesis to detect DNA damage responses.

  Mutation research 20100617

• Differential effects of nucleotide analogs on scanning-dependent initiation and elongation of mammalian mRNA translation in vitro.

  RNA (New York, N.Y.) 20100601

• Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions.

  PLoS pathogens 20100601

• DNA-mediated electron transfer in naphthalene-modified oligonucleotides.

  The Journal of organic chemistry 20100416

• 'Broken symmetries' in macromolecular crystallography: phasing from unmerged data.

  Acta crystallographica. Section D, Biological crystallography 20100401

• Localization of DNA and RNA in eosinophil secretory granules.

  International archives of allergy and immunology 20100101

• The polyembryonic wasp Copidosoma floridanum produces two castes by differentially parceling the germ line to daughter embryos during embryo proliferation.

  Development genes and evolution 20091001

• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

  Cell 20081212

• Electron transfer through a stable phenanthrenyl pair in DNA.

  Chemical communications (Cambridge, England) 20081114

• Subcellular imaging of RNA distribution and DNA replication in single mammalian cells with SIMS: the localization of heat shock induced RNA in relation to the distribution of intranuclear bound calcium.

  Journal of microscopy 20081001

• Novel derivatives of UDP-glucose: concise synthesis and fluorescent properties.

  Organic & biomolecular chemistry 20080821

• 5-Phenyluridine trihydrate.

  Acta crystallographica. Section C, Crystal structure communications 20080201

• Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia.

  BMC molecular biology 20080101

• NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue.

  PloS one 20080101

• Three-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelle.

  PLoS biology 20070901

• Localization of RNA transcription sites in insect oocytes using microinjections of 5-bromouridine 5'-triphosphate.

  Folia histochemica et cytobiologica 20070101

• [SC35 splicing factor and coilin are colocalized within the 'endobodies' in oocytes of the spider Araneus diadematus].

  Tsitologiia 20070101

• Purinergic receptors in human placenta: evidence for functionally active P2X4, P2X7, P2Y2, and P2Y6.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060501

• Pns12 protein of Rice dwarf virus is essential for formation of viroplasms and nucleation of viral-assembly complexes.

  The Journal of general virology 20060201

• Subcellular localization of protein kinase C delta and epsilon affects transcriptional and post-transcriptional processes in four-cell mouse embryos.

  Reproduction (Cambridge, England) 20051001

• Very slow turnover of beta-cells in aged adult mice.

  Diabetes 20050901

• Changes in extranucleolar transcription during actinomycin D-induced apoptosis.

  Histology and histopathology 20050101

• [Antiviral activity of different drugs in vitro against viruses of bovine infectious rhinotracheitis and bovine diarrhea].

  Voprosy virusologii 20040101

• Replication of hepatitis C virus RNA occurs in a membrane-bound replication complex containing nonstructural viral proteins and RNA.

  The Journal of general virology 20031001

• Characterisation of an uridine-specific binding site in rat cerebrocortical homogenates.

  Neurochemistry international 20030701

• Formation of 3'-O-beta-galactosyl compounds of 5-bromouridine by Sporobolomyces singularis.

  Bioscience, biotechnology, and biochemistry 20030301

• Visualization of transcription sites at the electron microscope.

  European journal of histochemistry : EJH 20030101

• Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.

  Molecular pharmacology 20010501

• Flow cytometric analysis of RNA synthesis by detection of bromouridine incorporation.

  Current protocols in cytometry 20010501

• Electric field-mediated BrUTP uptake by mouse oocytes, eggs, and embryos.

  Molecular reproduction and development 20010201

• Analysis of RNA synthesis by cytometry.

  Methods in cell biology 20010101

• Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.

  Journal of medicinal chemistry 19890201

• Interaction of monoclonal antibodies directed against bromodeoxyuridine with pyrimidine bases, nucleosides, and DNA.

  Journal of immunology (Baltimore, Md. : 1950) 19860301