-
Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20150415
-
Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine.
Medical oncology (Northwood, London, England) 20121201
-
HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation.
The Journal of nutritional biochemistry 20121001
-
Topical eflornithine hydrochloride improves the effectiveness of standard laser hair removal for treating pseudofolliculitis barbae: a randomized, double-blinded, placebo-controlled trial.
Journal of the American Academy of Dermatology 20121001
-
Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO)Â +Â sulindac for the prevention of sporadic colorectal adenomas.
Cancer causes & control : CCC 20121001
-
Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis.
American journal of physiology. Cell physiology 20120701
-
The investigation and management of hirsutism.
The journal of family planning and reproductive health care 20120701
-
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis.
Parasitology 20120601
-
Combination chemoprevention: future direction of colorectal cancer prevention.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20120501
-
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.
PLoS neglected tropical diseases 20120501
-
The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.
British journal of pharmacology 20120401
-
Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts.
Biochimica et biophysica acta 20120401
-
Ribonuclease activity of p53 in cytoplasm in response to various stress signals.
Cell cycle (Georgetown, Tex.) 20120401
-
Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.
The Biochemical journal 20120315
-
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Nature 20120125
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Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.
Pharmacology, biochemistry, and behavior 20120101
-
Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20120101
-
The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries.
PloS one 20120101
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[Analysis of oncogenic signaling pathway induced by a myeloproliferative neoplasm-associated Janus kinase 2 (JAK2) V617F mutant].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101
-
Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels.
Investigative ophthalmology & visual science 20111201
-
In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
Phytochemistry 20111101
-
Nonmelanoma skin cancer chemoprevention.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20111101
-
[Congenital human African trypanosomiasis: an observation at the University Hospital of Brazzaville (Congo)].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20111001
-
Drug resistance in human African trypanosomiasis.
Future microbiology 20110901
-
Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design.
Journal of medicinal chemistry 20110811
-
Role of peripheral polyamines in the development of inflammatory pain.
Biochemical pharmacology 20110801
-
Target repurposing for neglected diseases.
Future medicinal chemistry 20110801
-
DFMO: targeted risk reduction therapy for colorectal neoplasia.
Best practice & research. Clinical gastroenterology 20110801
-
Reversal of difluoromethylornithine effects by the administration of putrescine in rats.
JPMA. The Journal of the Pakistan Medical Association 20110801
-
The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.
Journal of medicinal chemistry 20110714
-
Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.
Cancer prevention research (Philadelphia, Pa.) 20110701
-
Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.
American journal of physiology. Gastrointestinal and liver physiology 20110701
-
Biomarkers in exploring the frontiers of diagnosis, prognosis, and therapy of Barrett's esophagus.
Cancer prevention research (Philadelphia, Pa.) 20110601
-
Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia.
Cancer prevention research (Philadelphia, Pa.) 20110601
-
Studies on cell migration model in intestinal epithelial restitution for pharmacological research.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501
-
A pro-survival effect of polyamine depletion on norepinephrine-mediated apoptosis in cardiac cells: role of signaling enzymes.
Amino acids 20110401
-
Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice.
Molecular and biochemical parasitology 20110401
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[Nifurtimox, a bright future for treatment of Chagas disease].
Medecine tropicale : revue du Corps de sante colonial 20110401
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Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.
Molecular and biochemical parasitology 20110301
-
New agents for prevention of ultraviolet-induced nonmelanoma skin cancer.
Seminars in cutaneous medicine and surgery 20110301
-
Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.
Molecular and biochemical parasitology 20110101
-
Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.
PloS one 20110101
-
Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma.
Arzneimittel-Forschung 20110101
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Repeated agmatine treatment attenuates nicotine sensitization in mice: modulation by alpha2-adrenoceptors.
Behavioural brain research 20101201
-
Potential new drugs for human African trypanosomiasis: some progress at last.
Current opinion in infectious diseases 20101201
-
Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.
Carcinogenesis 20101101
-
Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
Anti-cancer drugs 20101101
-
[Pseudofolliculitis barbae].
Actas dermo-sifiliograficas 20101101
-
A molecular mechanism for eflornithine resistance in African trypanosomes.
PLoS pathogens 20101101
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Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients.
Journal of the National Cancer Institute 20101006
-
Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells.
Experimental cell research 20101001
-
Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.
Gastroenterology 20101001
-
Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.
Gastroenterology 20100901
-
Polyamines and hair: a couple in search of perfection.
Experimental dermatology 20100901
-
Smoothened antagonists for hair inhibition.
Bioorganic & medicinal chemistry letters 20100815
-
Chemotherapy for second-stage Human African trypanosomiasis.
The Cochrane database of systematic reviews 20100804
-
Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract.
American journal of physiology. Gastrointestinal and liver physiology 20100801
-
Best practice options for hair removal in patients with unwanted facial hair using combination therapy with laser: guidelines drawn up by an expert working group.
Dermatology (Basel, Switzerland) 20100801
-
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.
European journal of pharmacology 20100710
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Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-L-cysteine and liquid chromatography with UV detection.
Biomedical chromatography : BMC 20100701
-
Comprehensive clinical management of hirsutism.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100701
-
Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Journal of cellular and molecular medicine 20100601
-
Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.
Anticancer research 20100601
-
NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness.
PLoS neglected tropical diseases 20100501
-
The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.
The Journal of biological chemistry 20100423
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Late-stage human African trypanosomiasis in a Sudanese refugee.
The Medical journal of Australia 20100405
-
Hirsutism: Diagnosis and management.
Gender medicine 20100401
-
Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture.
Experimental dermatology 20100301
-
Difluoromethylornithine inhibits hypertrophic, pro-fibrotic and pro-apoptotic actions of aldosterone in cardiac cells.
Amino acids 20100201
-
Computed tomographic features of oral squamous cell carcinoma in cats: 18 cases (2002-2008).
Journal of the American Veterinary Medical Association 20100201
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[Human African trypanosomiasis: description of two pediatric cases in Yaoundé, Cameroon].
Medecine tropicale : revue du Corps de sante colonial 20100201
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Human African trypanosomiasis.
Lancet (London, England) 20100109
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Killer coma: the evolving story of sleeping sickness treatment.
Lancet (London, England) 20100109
-
Fever of unknown origin in an infant with an unexpected blood film report: a case report.
Rural and remote health 20100101
-
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.
Cancer prevention research (Philadelphia, Pa.) 20100101
-
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.
PLoS neglected tropical diseases 20100101
-
Effects of oral administration of synthesized delta-amides of eflornithine in the rat.
Arzneimittel-Forschung 20100101
-
Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue.
World journal of urology 20091201
-
S-Nitrosylation of secreted recombinant human glypican-1.
Glycoconjugate journal 20091201
-
Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome.
American journal of physiology. Cell physiology 20091201
-
Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry.
Analytical and quantitative cytology and histology 20091201
-
Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway.
Organic & biomolecular chemistry 20091121
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Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.
Essays in biochemistry 20091104
-
Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells.
The international journal of biochemistry & cell biology 20091101
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Inner ear protection and regeneration: a 'historical' perspective.
Current opinion in otolaryngology & head and neck surgery 20091001
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Role of polyamines and cAMP-dependent mechanisms on 5alpha-dihydrotestosterone-elicited functional effects in isolated right atria of rat.
Journal of cardiovascular pharmacology 20091001
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Nutrition and colon cancer prevention.
Current opinion in clinical nutrition and metabolic care 20090901
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Hirsutism.
BMJ (Clinical research ed.) 20090828
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Recent advances in the development of polyamine analogues as antitumor agents.
Journal of medicinal chemistry 20090813
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The change of antizyme inhibitor expression and its possible role during mammalian cell cycle.
Experimental cell research 20090801
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Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats.
Neuroscience 20090707
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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.
Lancet (London, England) 20090704
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NECT trial: more than a small victory over sleeping sickness.
Lancet (London, England) 20090704
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Green tea extract: a novel addition to the antihirsutism armamentarium?
Journal of alternative and complementary medicine (New York, N.Y.) 20090701
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Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
The Journal of pharmacology and experimental therapeutics 20090601
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Magnetic resonance imaging findings in human African trypanosomiasis: a four-year follow-up study in a patient and review of the literature.
The American journal of tropical medicine and hygiene 20090601
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Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine modulation and diabetic alteration.
The Journal of physiology 20090515
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Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.
Journal of medicinal chemistry 20090409
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Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function.
American journal of physiology. Cell physiology 20090401
-
Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome.
Oncology reports 20090401
-
Off-label use of approved drugs.
Nature reviews. Clinical oncology 20090401
-
Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.
Bioorganic & medicinal chemistry 20090315
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Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20090301
-
Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats.
Pharmacology, biochemistry, and behavior 20090301
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Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas.
Cancer prevention research (Philadelphia, Pa.) 20090301
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Effect ofalpha-difluormethylornithine on Anastrepha fraterculus (Diptera, Tephritidae) ovary size.
Brazilian journal of biology = Revista brasleira de biologia 20090201
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Reducing the risk of recurrent colon polyps.
Clinical advances in hematology & oncology : H&O 20090201
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Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.
Cancer research 20090115
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Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.
The Journal of biological chemistry 20090109
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Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.
Cancer letters 20090108
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Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol.
Journal of plant physiology 20090101
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The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries.
British journal of pharmacology 20090101
-
[Agents for the treatment of African sleeping sickness. Those developed in the last century].
Pharmazie in unserer Zeit 20090101
-
[Molecular functions of polyamines in neoplastic growth and their role in control of the NF-kappaB transcription factor in experimental tumors cells].
Likars'ka sprava 20090101
-
Effect of difluoromethylornithine on thyroid function in rats.
Journal of Ayub Medical College, Abbottabad : JAMC 20090101
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Spermine-induced morphogenesis and effect of partial immersion system on the shoot cultures of banana.
Applied biochemistry and biotechnology 20081201
-
Polycystic ovary syndrome (PCOS) trilogy: a translational and clinical review.
Clinical endocrinology 20081201
-
ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.
Cancer research 20081201
-
Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.
Cancer research 20081201
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Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.
Cancer prevention research (Philadelphia, Pa.) 20081201
-
Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat.
European journal of pharmacology 20081119
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Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.
Cancer research 20081115
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Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.
Breast cancer research and treatment 20081101
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The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain.
Journal of neurochemistry 20081101
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Chemoprevention of bladder cancer.
BJU international 20081101
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Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt.
American journal of physiology. Renal physiology 20081001
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Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.
Endocrinology 20081001
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Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice.
Carcinogenesis 20080801
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Role of putrescine on androgen-elicited positive inotropism in the left atrium of rats.
Journal of cardiovascular pharmacology 20080801
-
Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes.
Journal of cellular physiology 20080701
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Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target.
Molecular and biochemical parasitology 20080701
-
Drugs to prevent colon cancer show promise, but hurdles remain for chemoprevention.
Journal of the National Cancer Institute 20080604
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High-frequency ultrasonic atomization for drug delivery to rodent animal models - optimal particle size for lung inhalation of difluoromethyl ornithine.
Experimental lung research 20080601
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Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial.
Cancer prevention research (Philadelphia, Pa.) 20080601
-
Clinical prevention of recurrence of colorectal adenomas by the combination of difluoromethylornithine and sulindac: an important milestone.
Cancer prevention research (Philadelphia, Pa.) 20080601
-
Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period.
Endocrinology 20080501
-
Making a difference: 30 years of TDR.
Nature reviews. Microbiology 20080501
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Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation.
International journal of oncology 20080401
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African sleeping sickness.
BMJ (Clinical research ed.) 20080329
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Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study.
BMJ (Clinical research ed.) 20080329
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Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocytic leukemia HL60 cells.
Toxicology in vitro : an international journal published in association with BIBRA 20080301
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Hirsutism.
International journal of clinical practice 20080301
-
Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes.
Journal of cellular biochemistry 20080301
-
Polyamine metabolism during sclerotial development of Sclerotinia sclerotiorum.
Mycological research 20080301
-
Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips.
Acta biologica Hungarica 20080301
-
Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and alpha-keto acid homeostasis?
Amino acids 20080201
-
Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion.
Biological chemistry 20080201
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The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080201
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Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola.
Tropical medicine & international health : TM & IH 20080201
-
Idiopathic hirsutism: excessive bodily and facial hair in women.
British journal of nursing (Mark Allen Publishing) 20080201
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Validation of spermidine synthase as a drug target in African trypanosomes.
The Biochemical journal 20080115
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Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
Breast cancer research and treatment 20080101
-
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Breast cancer research and treatment 20080101
-
Chemoprevention with special reference to inherited colorectal cancer.
Familial cancer 20080101
-
A 4-month, open-label study evaluating the efficacy of eflornithine 11.5% cream in the treatment of unwanted facial hair in women using TrichoScan.
European journal of dermatology : EJD 20080101
-
Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme.
PLoS neglected tropical diseases 20080101
-
Hypothesis: the potential utility of topical eflornithine against cutaneous leishmaniasis.
Indian journal of dermatology, venereology and leprology 20080101
-
Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis.
Nutrition and cancer 20080101
-
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
Cellular signalling 20071201
-
Trypanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites.
Biochimica et biophysica acta 20071201
-
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201
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Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201
-
Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis).
Tropical medicine & international health : TM & IH 20071201
-
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
The Journal of biological chemistry 20071130
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Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy.
International journal of cancer 20071115
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Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
International journal of oncology 20071101
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Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series.
PLoS neglected tropical diseases 20071101
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Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.
The Journal of biological chemistry 20070914
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Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and alpha-keto acid homeostasis or immunocompetence.
Amino acids 20070901
-
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Breast cancer research and treatment 20070901
-
Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity.
American journal of physiology. Gastrointestinal and liver physiology 20070901
-
The effect of eflornithine 13.9% cream on the bother and discomfort due to hirsutism.
International journal of dermatology 20070901
-
Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention.
Amino acids 20070801
-
Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide.
Amino acids 20070801
-
Polyamines and mRNA stability in regulation of intestinal mucosal growth.
Amino acids 20070801
-
Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential.
Amino acids 20070801
-
Kidney growth, hypertrophy and the unifying mechanism of diabetic complications.
Amino acids 20070801
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Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
American journal of physiology. Cell physiology 20070801
-
Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells.
Amino acids 20070801
-
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Amino acids 20070801
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Does eflornithine help women face hirsutism?
Drug and therapeutics bulletin 20070801
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A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women.
Journal of the American Academy of Dermatology 20070701
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p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion.
American journal of physiology. Cell physiology 20070701
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Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.
International journal of oncology 20070701
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Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion.
The Biochemical journal 20070501
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Difluoromethylornithine decreases long-lasting protein oxidation induced by neonatal ethanol exposure in the hippocampus of adolescent rats.
Alcoholism, clinical and experimental research 20070501
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Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts.
International journal of molecular medicine 20070501
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Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels.
American journal of physiology. Endocrinology and metabolism 20070401
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Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models.
Biochemical Society transactions 20070401
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Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent.
Biochemical Society transactions 20070401
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Astroglia growth retardation and increased microglia proliferation by lithium and ornithine decarboxylase inhibitor in rat cerebellar cultures: Cytotoxicity by combined lithium and polyamine inhibition.
Journal of neuroscience research 20070215
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Determination of eflornithine enantiomers in plasma, by solid-phase extraction and liquid chromatography with evaporative light-scattering detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201
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HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.
Molecular cancer therapeutics 20070201
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Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair.
International journal of dermatology 20070101
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[Characteristics of polyamine biosynthesis regulation and tumor growth rate in hormone-dependant grafted breast tumors of mice and rats].
Likars'ka sprava 20070101
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Eflornithine.
Indian journal of dermatology, venereology and leprology 20070101
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Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20061201
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Polyamines, PI(4,5)P2, and actin polymerization.
Journal of cellular physiology 20061101
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Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors.
Molecular cancer therapeutics 20061101
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Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20061001
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Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo.
Bulletin of the World Health Organization 20061001
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Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo.
Bulletin of the World Health Organization 20061001
-
The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase.
Biochemical pharmacology 20060928
-
New dimensions in Hirsutism.
Lasers in medical science 20060901
-
Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene.
Life sciences 20060822
-
Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3.
The Biochemical journal 20060801
-
Randomized prospective phase III trial of difluoromethylornithine vs placebo in preventing recurrence of completely resected low risk superficial bladder cancer.
The Journal of urology 20060801
-
Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs.
The Journal of biological chemistry 20060714
-
Nitric oxide and polyamine pathway-dependent modulation of neutrophil free amino- and alpha-keto acid profiles or host defense capability.
Amino acids 20060701
-
In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition.
International journal of cancer 20060601
-
Treatment of hirsutism and acne in hyperandrogenism.
Best practice & research. Clinical endocrinology & metabolism 20060601
-
Excess salt and pepper hair treated with a combination of laser hair removal and topical eflornithine HCl.
Journal of drugs in dermatology : JDD 20060601
-
Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.
International journal of cancer 20060501
-
The rise and fall of sleeping sickness.
Lancet (London, England) 20060429
-
Examples of tropical disease control in the humanitarian medical programmes of MSF and Merlin.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20060401
-
alpha-Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo-prevention.
International journal of dermatology 20060401
-
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
The Journal of parasitology 20060401
-
Role of polyamines derived from arginine in differentiation and proliferation of human blood cells.
Biological & pharmaceutical bulletin 20060201
-
Understanding the causes and management of hirsutism.
Nursing times 20060201
-
Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines.
Journal of medicinal chemistry 20060112
-
Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha.
Journal of cellular physiology 20060101
-
Induction of apoptotic cell death by putrescine.
The international journal of biochemistry & cell biology 20060101
-
Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.
Oncology 20060101
-
STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.
The Biochemical journal 20051201
-
Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
Cancer research 20051201
-
Treatments for unwanted facial hair.
Skin therapy letter 20051201
-
[Effect of alpha-difluoromethylornithine and polyhexamethyleneguanidine (PMG), polyamine biosynthesis inhibitors on leucosis L1210 growth kinetics and life expectancy of animals with cancer].
Likars'ka sprava 20051201
-
Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101
-
A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene.
Annals of the New York Academy of Sciences 20051101
-
[Effect of alpha-difluoromethylornithine on the expression of ODC mRNA in the cortex and hippocampus in rats after cerebral ischemia reperfusion].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20051001
-
Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells.
The Journal of biological chemistry 20050902
-
Polyamine depletion inhibits irradiation-induced apoptosis in intestinal epithelia.
American journal of physiology. Gastrointestinal and liver physiology 20050901
-
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050901
-
Karyometry in the early detection and chemoprevention of intraepithelial lesions.
European journal of cancer (Oxford, England : 1990) 20050901
-
Suppression and regression of choroidal neovascularization by polyamine analogues.
Investigative ophthalmology & visual science 20050901
-
Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells.
Stem cells (Dayton, Ohio) 20050801
-
Guidance for the management of hirsutism.
Current medical research and opinion 20050801
-
Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity.
Apoptosis : an international journal on programmed cell death 20050801
-
Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes.
Differentiation; research in biological diversity 20050701
-
Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 20050601
-
Polyamines protect against radiation-induced oxidative stress.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 20050601
-
B23 is a downstream target of polyamine-modulated CK2.
Molecular and cellular biochemistry 20050601
-
Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors.
World journal of gastroenterology 20050528
-
Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons.
Journal of neurophysiology 20050501
-
Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats.
Journal of hypertension 20050501
-
Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells.
Kidney international 20050501
-
Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.
Cancer cell 20050501
-
Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050501
-
Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity.
The Journal of biological chemistry 20050415
-
Molecular mechanisms of polyamine analogs in cancer cells.
Anti-cancer drugs 20050301
-
Depletion of polyamines and increase of transforming growth factor-beta1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblasts.
Journal of periodontology 20050301
-
Independent roles of eIF5A and polyamines in cell proliferation.
The Biochemical journal 20050201
-
Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization.
Endocrinology 20050201
-
Colorectal cancer prevention: is an ounce of prevention worth a pound of cure?
Seminars in oncology 20050201
-
Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis.
Cancer research 20050115
-
Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050101
-
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
Clinical & experimental metastasis 20050101
-
Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.
Breast cancer research : BCR 20050101
-
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Clinical & experimental metastasis 20050101
-
[Key aspects of excessive hair in 2005].
Annales de dermatologie et de venereologie 20050101
-
[Eflornithine: evidence of efficacy].
Annales de dermatologie et de venereologie 20050101
-
[Vaniqa in daily practice].
Annales de dermatologie et de venereologie 20050101
-
[Vaniqa and laser depilation in practice].
Annales de dermatologie et de venereologie 20050101
-
Polycystic ovary syndrome (PCOS) in the adolescent patient: recommendations for practice.
Pediatric nursing 20050101
-
Lung distribution of the chemopreventive agent difluoromethylornithine (DFMO) following oral and inhalation delivery.
Experimental lung research 20041201
-
The role of polyamines in human cancer: prospects for drug combination therapies.
Hawaii medical journal 20041201
-
Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20041101
-
Polyamines regulate eukaryotic initiation factor 4E-binding protein 1 gene transcription.
Biochemical and biophysical research communications 20041008
-
Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors.
Carcinogenesis 20041001
-
Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts.
Amino acids 20041001
-
Polyamines and cancer: old molecules, new understanding.
Nature reviews. Cancer 20041001
-
Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells.
Experimental oncology 20040901
-
Protective role of arginase in a mouse model of colitis.
Journal of immunology (Baltimore, Md. : 1950) 20040801
-
Polyamine depletion switches the form of 2-deoxy-D-ribose-induced cell death from apoptosis to necrosis in HL-60 cells.
The international journal of biochemistry & cell biology 20040701
-
A novel role for polyamines in adult neurogenesis in rodent brain.
The European journal of neuroscience 20040701
-
Irreversible ototoxicity associated with difluoromethylornithine.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040701
-
Inhibitors of polyamine metabolism: review article.
Amino acids 20040701
-
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
The Journal of biological chemistry 20040625
-
The pharmacokinetics of eflornithine (alpha-difluoromethylornithine) in patients with late-stage T.b. gambiense sleeping sickness.
European journal of clinical pharmacology 20040601
-
Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.
European journal of cancer (Oxford, England : 1990) 20040601
-
Difluoromethylornithine-induced reversible hearing loss across a wide frequency range.
The Laryngoscope 20040601
-
Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion.
The Journal of biological chemistry 20040521
-
Activation of the Akt/nuclear factor-kappaB signaling axis in developing lung neoplasia.
Chest 20040501
-
[Clinical reasoning and decision making in practice. A depressive foreign woman with symptoms of malaise].
Nederlands tijdschrift voor geneeskunde 20040417
-
The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells.
Molecular carcinogenesis 20040401
-
Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil.
Cancer research 20040401
-
Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice.
The Journal of clinical investigation 20040315
-
The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas.
American journal of obstetrics and gynecology 20040301
-
Possible cases of sexual and congenital transmission of sleeping sickness.
Lancet (London, England) 20040117
-
Review article: chemoprevention of colorectal cancer.
Alimentary pharmacology & therapeutics 20040101
-
Retaking sleeping sickness control in Angola.
Tropical medicine & international health : TM & IH 20040101
-
Developmental treatment with difluoromethylornithine has few effects on behavior or body weight in Sprague-Dawley rats.
Neurotoxicology and teratology 20040101
-
Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention.
Environmental and molecular mutagenesis 20040101
-
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
Clinical & experimental metastasis 20040101
-
Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201
-
Hexachlorobenzene-induced early changes in ornithine decarboxylase and protein tyrosine kinase activities, polyamines and c-Myc, c-Fos and c-Jun proto-oncogenes in rat liver.
Toxicological sciences : an official journal of the Society of Toxicology 20031201
-
[Apoptotic induction of human lung carcinoma A549 cells by DFMO through Fas/FasL pathway].
Ai zheng = Aizheng = Chinese journal of cancer 20031201
-
A perspective of polyamine metabolism.
The Biochemical journal 20031115
-
Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 20031101
-
Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells.
American journal of physiology. Gastrointestinal and liver physiology 20031101
-
Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation.
Experimental cell research 20031101
-
Alpha-difluoromethylornithine, ornithine decarboxylase inhibitor, antagonizes H2O2-induced cytotoxicity in HL-60 leukemia cells: regulation of iron-dependent lysosomal damage.
Cell biology and toxicology 20031101
-
Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine.
The Biochemical journal 20031015
-
Modulation by alpha-difluoromethyl-ornithine and aminoguanidine of pain threshold, morphine analgesia and tolerance.
European journal of pharmacology 20031008
-
RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity.
American journal of physiology. Gastrointestinal and liver physiology 20031001
-
Antimalarial effect of agmatine on Plasmodium berghei K173 strain.
Acta pharmacologica Sinica 20030901
-
Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.
Brain research 20030815
-
Lytic infection of pseudorabies virus in the presence of spermine, spermidine, or DFMO.
Virus research 20030801
-
The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal rat cardiac myocytes.
European journal of pharmacology 20030801
-
Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis.
Cancer research 20030715
-
In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry.
Cancer research 20030701
-
Pseudofolliculitis barbae: review and update on new treatment modalities.
Military medicine 20030701
-
Barrett's esophagus: chemoprevention.
Gastrointestinal endoscopy clinics of North America 20030701
-
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Cancer research 20030615
-
Polyamines in cultured rabbit corneal cells.
Investigative ophthalmology & visual science 20030601
-
Current chemotherapy of human African trypanosomiasis.
Parasitology research 20030601
-
Eflornithine for the treatment of human African trypanosomiasis.
Parasitology research 20030601
-
High-performance liquid chromatographic method for determination of 2-difluoromethyl-DL-ornithine in plasma and cerebrospinal fluid.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525
-
Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity.
Oncogene 20030501
-
The evaluation and management of hirsutism.
Obstetrics and gynecology 20030501
-
Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.
Carcinogenesis 20030501
-
The requirement for polyamines for intestinal epithelial cell migration is mediated through Rac1.
The Journal of biological chemistry 20030411
-
Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.
International journal of cancer 20030410
-
Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030301
-
Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate.
Gut 20030201
-
Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture.
Biochimica et biophysica acta 20030120
-
Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.
BMC cancer 20030101
-
Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries.
Plant physiology 20030101
-
Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates.
Journal of medical virology 20030101
-
Suramin selectively inhibits carcinoma cell growth that is dependent on extracellular polyamines.
Anticancer research 20030101
-
Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice.
Clinical & experimental metastasis 20030101
-
[Eflornithine in the treatment of African trypanosomiasis].
Medecine tropicale : revue du Corps de sante colonial 20030101
-
[The return of sleeping sickness in an epidemic form: international action for drugs].
Nederlands tijdschrift voor geneeskunde 20021228
-
Polyamine metabolism as chemotherapeutic target in protozoan parasites.
Mini reviews in medicinal chemistry 20021201
-
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.
Carcinogenesis 20021201
-
Removal of unwanted facial hair.
American family physician 20021115
-
Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.
Journal of medicinal chemistry 20021107
-
A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research 20021001
-
Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.
FEBS letters 20020911
-
Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration.
American journal of physiology. Cell physiology 20020901
-
Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents.
Carcinogenesis 20020901
-
Effect of polyamine depletion on cone photoreceptors of the developing rabbit retina.
Investigative ophthalmology & visual science 20020901
-
Resurrecting the resurrection drug.
Nature medicine 20020901
-
Combination of eflornithine and melarsoprol for melarsoprol-resistant Gambian trypanosomiasis.
Tropical medicine & international health : TM & IH 20020901
-
Polyamine-mediated post-transcriptional regulation of COX-2.
Biochimie 20020801
-
[Effect of alpha-difluoromethylornithine on growth characteristics and expression of ALT-04ag gene of human lung carcinoma cells].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020801
-
Stress-induced dynamic changes in mouse brain polyamines. Role in behavioral reactivity.
Brain research 20020705
-
Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205.
Molecular endocrinology (Baltimore, Md.) 20020701
-
RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion.
Gastroenterology 20020701
-
Treatment of human African trypanosomiasis--present situation and needs for research and development.
The Lancet. Infectious diseases 20020701
-
Polyamine uptake is necessary for a normal biochemical maturation of astrocytes in culture.
Neuroreport 20020612
-
Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c.
American journal of physiology. Cell physiology 20020601
-
Involvement of polyamines in root development at low temperature in the subantarctic cruciferous species Pringlea antiscorbutica.
Journal of experimental botany 20020601
-
Are polyamines involved in olfaction? An EAG and biochemical study in Periplaneta americana antennae.
Chemical senses 20020601
-
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
Oncogene 20020516
-
Effects of difluoromethylornithine on growth inhibition and apoptosis in human cervical epithelial and cancerous cell lines.
Gynecologic oncology 20020501
-
Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives.
Clinical cancer research : an official journal of the American Association for Cancer Research 20020501
-
The preovulatory rise of ovarian ornithine decarboxylase is required for progesterone secretion by the corpus luteum.
Biochemical and biophysical research communications 20020426
-
Quantitation of polyamines in hypothalamus and pituitary of female and male developing rats.
Neuroscience letters 20020419
-
Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding.
American journal of physiology. Cell physiology 20020401
-
Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats.
Experimental biology and medicine (Maywood, N.J.) 20020401
-
Polyamine-dependent migration of retinal pigment epithelial cells.
Investigative ophthalmology & visual science 20020401
-
Plating densities, alpha-difluoromethylornithine effects and time dependence on the proliferation of IEC-6 cells.
Chinese medical journal 20020401
-
Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines.
Clinical science (London, England : 1979) 20020301
-
Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice.
Cancer research 20020301
-
Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat.
Life sciences 20020208
-
Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition.
Biochimica et biophysica acta 20020130
-
[Chemoprevention of colorectal cancer].
Presse medicale (Paris, France : 1983) 20020126
-
Activities of arginase I and II are limiting for endothelial cell proliferation.
American journal of physiology. Regulatory, integrative and comparative physiology 20020101
-
Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20020101
-
Chemoprevention of colorectal cancer.
The American journal of gastroenterology 20020101
-
The ornithine decarboxylase inhibitor, difluoromethylornithine, inhibits casein kinase II activity, c-Myc expression and normal human keratinocyte proliferation.
Archives of dermatological research 20020101
-
Glucocorticoids and polyamine inhibitors synergize to kill human leukemic CEM cells.
Neoplasia (New York, N.Y.) 20020101
-
Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells.
Clinical & experimental metastasis 20020101
-
Winterbottom's sign and hypertrophic cardiomyopathy.
Scandinavian journal of infectious diseases 20020101
-
Chemoprevention of prostate carcinogenesis by DFMO and/or finasteride treatment in male Wistar rats.
Tumori 20020101
-
Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells.
The Journal of biological chemistry 20011207
-
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.
Journal of immunology (Baltimore, Md. : 1950) 20011201
-
Eflornithine.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011201
-
Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc 1638N [+/-] mouse.
Annals of the New York Academy of Sciences 20011201
-
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.
Annals of the New York Academy of Sciences 20011201
-
The future of colon cancer prevention.
Annals of the New York Academy of Sciences 20011201
-
The effect of polyamine biosynthesis inhibition on growth and differentiation of the phytopathogenic fungus Sclerotinia sclerotiorum.
Antonie van Leeuwenhoek 20011201
-
No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stunting.
Behavioural brain research 20011129
-
Spermidine is essential for normal proliferation of trypanosomatid protozoa.
FEBS letters 20011123
-
The eflornithine story.
Journal of the American Academy of Dermatology 20011101
-
Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.
Cancer research 20011101
-
Availability and affordability of treatment for Human African Trypanosomiasis.
Tropical medicine & international health : TM & IH 20011101
-
Cell culture analysis of the regulatory frameshift event required for the expression of mammalian antizymes.
Genes to cells : devoted to molecular & cellular mechanisms 20011101
-
[Current treatment of hypertrichosis].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20011101
-
The effect of DFMO induced uptake of [3H] putrescine on human glioma cells.
Journal of neuro-oncology 20011101
-
Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors.
Journal of medicinal chemistry 20011025
-
2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice.
Cancer research 20011015
-
Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation.
American journal of physiology. Cell physiology 20010901
-
Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair.
Journal of clinical pharmacology 20010901
-
Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer.
Cellular and molecular biology (Noisy-le-Grand, France) 20010901
-
Measurement of chemopreventive efficacy in skin biopsies.
Analytical and quantitative cytology and histology 20010801
-
[Effect of inhibition of polyamine biosynthesis on the growth and telomerase activity of human laryngeal carcinoma cells Hep-2].
Zhonghua er bi yan hou ke za zhi 20010801
-
Polyamines regulate gap junction communication in connexin 43-expressing cells.
The Biochemical journal 20010715
-
Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms.
American journal of physiology. Gastrointestinal and liver physiology 20010701
-
Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model.
Tree physiology 20010701
-
Thank God for rich women with mustaches.
Medicine and health, Rhode Island 20010701
-
Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture.
Breast cancer research and treatment 20010701
-
A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia.
Archives of internal medicine 20010625
-
Increases in ornithine decarboxylase activity in the positive inotropism induced by androgens in isolated left atrium of the rat.
European journal of pharmacology 20010622
-
A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line.
Biochemical pharmacology 20010601
-
Phase I chemoprevention study of difluoromethylornithine in subjects with organ transplants.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010601
-
NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 20010501
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Transporters in African trypanosomes: role in drug action and resistance.
International journal for parasitology 20010501
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Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501
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Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissions.
Archives of otolaryngology--head & neck surgery 20010501
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Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.
Tropical medicine & international health : TM & IH 20010501
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Delayed, reversible hearing loss caused by difluoromethylornithine (DFMO).
The Laryngoscope 20010501
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Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi.
Biochemical and biophysical research communications 20010420
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Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration.
American journal of physiology. Cell physiology 20010401
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Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.
The Biochemical journal 20010401
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Prostate cancer prevention strategies using antiproliferative or differentiating agents.
Urology 20010401
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Vaniqa--eflornithine 13.9% cream.
Skin therapy letter 20010401
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Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity.
Journal of neuroscience research 20010301
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Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010301
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Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity.
Cellular and molecular biology (Noisy-le-Grand, France) 20010301
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Involvement of K(ATP) channels in diethylstilbestrol-induced relaxation in rat aorta.
European journal of pharmacology 20010209
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Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.
Cardiovascular research 20010201
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[Eflornithine for hair removal. Topical application for hirsutism].
Medizinische Monatsschrift fur Pharmazeuten 20010201
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p53 independent G(1) arrest induced by DL-alpha-difluoromethylornithine.
Biochemical and biophysical research communications 20010126
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Hypertrophy and hyperfunction of the diabetic kidney.
The Journal of clinical investigation 20010115
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Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.
The Journal of clinical investigation 20010115
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Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts.
The Journal of biological chemistry 20010112
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Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells.
Journal of the National Cancer Institute 20010103
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Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.
Journal of the National Cancer Institute 20010103
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Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice.
Carcinogenesis 20010101
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Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme.
International journal of radiation oncology, biology, physics 20010101
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Development of difluoromethyl-ornithine and Bowman-Birk inhibitor as chemopreventive agents by assessment of relevant biomarker modulation: some lessons learned.
IARC scientific publications 20010101
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Human dermal safety studies with eflornithine HCl 13.9% cream (Vaniqa), a novel treatment for excessive facial hair.
Current medical research and opinion 20010101
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Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation.
Anticancer research 20010101
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Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi.
The Journal of eukaryotic microbiology 20010101
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Induction of gastric ornithine decarboxylase in early weaning rats.
Digestion 20010101
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Hirsutism: diagnosis and management.
The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20010101
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Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor.
In vivo (Athens, Greece) 20010101
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Topical eflornithine.
American journal of clinical dermatology 20010101
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Characterization of spermine uptake by Ehrlich tumour cells in culture.
Amino acids 20010101
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Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice.
Experimental lung research 20001201
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Attenuation of isoproterenol-mediated myocardial injury in rat by an inhibitor of polyamine synthesis.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20000101
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Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart.
Life sciences 19990101
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Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells.
Biochemical pharmacology 19980415
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Rapid induction of apoptosis by deregulated uptake of polyamine analogues.
The Biochemical journal 19971115
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Inhibition by 1alpha,25-dihydroxyvitamin D3 of activin A-induced differentiation of murine erythroleukemic F5-5 cells.
Archives of biochemistry and biophysics 19970715
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Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney.
Biochimica et biophysica acta 19970527
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Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.
Antimicrobial agents and chemotherapy 19960401
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Polyamine depletion and growth inhibition of Cryptococcus neoformans by alpha-difluoromethylornithine and cyclohexylamine.
Mycopathologia 19901001
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Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia.
Antimicrobial agents and chemotherapy 19900901
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Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.
Antimicrobial agents and chemotherapy 19880801
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Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.
Antimicrobial agents and chemotherapy 19880601
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Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.
Lancet (London, England) 19871219
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Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine.
Journal of neuroscience research 19850101
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Factors which may be significant regarding regulation of the clofibrate-dependent induction of hepatic peroxisomal beta-oxidation and hepatomegaly.
Biochemical pharmacology 19840401
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Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19840201
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Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Journal of molecular and cellular cardiology 19820801