logo
Home > MGL-3196
MGL-3196 Synthesis
MGL-3196 (Synonyms: 2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile)
The renaming of NAFLD to MASLD and NASH to MASH emphasizes the metabolic dysregulation underlying these steatotic liver diseases.
MGL-3196
An agonist of TRβ
Item No. AX18166
CAS No. 920509-32-6
Purity: 95%
1mg
＄12.00
5mg
＄19.00
10mg
＄27.00
25mg
＄44.00
50mg
＄70.00
100mg
＄93.00
250mg
＄107.00
1g
＄270.00
5g
＄1,247.00
Quantity
-
+
Add to Cart
Buy Now
MGL-3196 Synthetic Route
AX09803
CAS: 107228-51-3
AB66565
CAS: 5930-28-9
AX05946
CAS: 920509-27-9
AX11576
CAS: 920509-28-0
AW34969
CAS: 68168-42-3
AX07638
CAS: 920509-33-7
AX18166
CAS: 920509-32-6 
1.1: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 24 h / 20 - 90 °C / Inert atmosphere
2.1: acetic acid; sodium acetate / 24 h / 100 °C / Inert atmosphere
2.2: 24 h / 120 °C / Inert atmosphere
3.1: sodium nitrate; hydrogenchloride / water / 0.5 h / 0 °C
3.2: 0 °C
4.1: acetic acid; sodium acetate / 1.5 h / 20 - 120 °C / Inert atmosphere
Order MGL-3196 Intermediates
Structure
Description
SDS
{{item['cas']}} | {{item['name']}}
MF:{{item['mf']}} MW:{{item['mw']}}
Download SDS
{{item.isExpand?'Hide':'Expand'}}
Catalog No.
Pack Size
Purity
Availability
Price
{{item['supplierPartNo']}}
{{sku['packsize']}}{{sku['packunit']}}
{{sku['purity']}}
{{sku['leadtime']}}
${{getUSMoneyFormat(sku['price'])}}
-
-
+
Add to Cart
Buy Now
References
1.Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 3912 – 3923
1Kelly, M.J., Pietranico-Cole, S., Larigan, J.D., et al. Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. J. Med. Chem. 57(10), 3912-3923 (2014).
Catalog No. {{modalData.supplierPartNo}} CAS：{{modalData.cas}}
close
{{sku['packsize']}}{{sku['packunit']}}
${{getUSMoneyFormat(sku['price'])}}
-
-
+
Add to Cart
Buy Now